The Complex Cyto-Molecular Landscape of Thyroid Nodules in Pediatrics.
fine-needle aspiration
molecular pathology
pediatrics
thyroid nodule
ultrasound
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
29 Mar 2023
29 Mar 2023
Historique:
received:
30
01
2023
revised:
09
03
2023
accepted:
27
03
2023
medline:
14
4
2023
entrez:
13
4
2023
pubmed:
14
4
2023
Statut:
epublish
Résumé
Thyroid fine-needle aspiration (FNA) is a commonly used diagnostic cytological procedure in pediatric patients for the evaluation of thyroid nodules, triaging them for the detection of thyroid cancer. In recent years, greater attention has been paid to thyroid FNA in this setting, including the use of updated ultrasound score algorithms to improve accuracy and yield, especially considering the theoretically higher risk of malignancy of these lesions compared with the adult population, as well as to minimize patient discomfort. Moreover, molecular genetic testing for thyroid disease is an expanding field of research that could aid in distinguishing benign from cancerous nodules and assist in determining their clinical management. Finally, artificial intelligence tools can help in this task by performing a comprehensive analysis of all the obtained data. These advancements have led to greater reliance on FNA as a first-line diagnostic tool for pediatric thyroid disease. This review article provides an overview of these recent developments and their impact on the diagnosis and management of thyroid nodules in children.
Identifiants
pubmed: 37046700
pii: cancers15072039
doi: 10.3390/cancers15072039
pmc: PMC10093758
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Regione Lombardia
ID : Ricerca Finalizzata GR-2019-12368592
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