High-Multiplex Aptamer-Based Serum Proteomics to Identify Candidate Serum Biomarkers of Oral Squamous Cell Carcinoma.
SOMAscan
biomarker
liquid biopsy
oral cancer
prognosis
proteomics
serum
therapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
30 Mar 2023
30 Mar 2023
Historique:
received:
25
02
2023
revised:
17
03
2023
accepted:
29
03
2023
medline:
14
4
2023
entrez:
13
4
2023
pubmed:
14
4
2023
Statut:
epublish
Résumé
Improved serological biomarkers are needed for the early detection, risk stratification and treatment surveillance of patients with oral squamous cell carcinoma (OSCC). We performed an exploratory study using advanced, highly specific, DNA-aptamer-based serum proteomics (SOMAscan, 1305-plex) to identify distinct proteomic changes in patients with OSCC pre- vs. post-resection and compared to healthy controls. A total of 63 significantly differentially expressed serum proteins (each
Identifiants
pubmed: 37046731
pii: cancers15072071
doi: 10.3390/cancers15072071
pmc: PMC10093013
pii:
doi:
Types de publication
Journal Article
Langues
eng
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