ZNF750: A Novel Prognostic Biomarker in Metastatic Prostate Cancer.
ZNF750
metastasis
prognostic biomarker
prostate cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Mar 2023
30 Mar 2023
Historique:
received:
08
02
2023
revised:
24
03
2023
accepted:
25
03
2023
medline:
14
4
2023
entrez:
13
4
2023
pubmed:
14
4
2023
Statut:
epublish
Résumé
Prostate cancer is the most frequently diagnosed cancer and the fifth leading cause of cancer death among men in 2020. The clinical decision making for prostate cancer patients is based on the stratification of the patients according to both clinical and pathological parameters such as Gleason score and prostate-specific antigen levels. However, these tools still do not adequately predict patient outcome. The aim of this study was to investigate whether ZNF750 could have a role in better stratifying patients, identifying those with a higher risk of metastasis and with the poorest prognosis. The data reported here revealed that ZNF750 protein levels are reduced in human prostate cancer samples, and this reduction is even higher in metastatic samples. Interestingly, nuclear positivity is significantly reduced in patients with metastatic prostate cancer, regardless of both Gleason score and grade group. More importantly, the bioinformatics analysis indicates that ZNF750 expression is positively correlated with better prognosis. Overall, our findings suggest that nuclear expression of ZNF750 may be a reliable prognostic biomarker for metastatic prostate cancer, which lays the foundation for the development of new biological therapies.
Identifiants
pubmed: 37047491
pii: ijms24076519
doi: 10.3390/ijms24076519
pmc: PMC10095592
pii:
doi:
Substances chimiques
Biomarkers
0
Prostate-Specific Antigen
EC 3.4.21.77
ZNF750 protein, human
0
Transcription Factors
0
Tumor Suppressor Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : "Ricerca Ateneo Beyond Borders" (D. R. n. 1347 del 29/05/2019)
ID : CUP# E84I20000650005
Organisme : "Associazione Italiana per la Ricerca contro il Cancro" (AIRC)
ID : IG 2022 ID 27366; 2023-2027
Organisme : Ministry Universities & Research PNRR-PE6- M4C2I1.3 PE6 project Heal Italia grant
ID : PE00000019
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