Imbalance of Essential Metals in Traumatic Brain Injury and Its Possible Link with Disorders of Consciousness.
Alzheimer’s disease
copper
disorders of consciousness
iron
metals
traumatic brain injury
zinc
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Apr 2023
06 Apr 2023
Historique:
received:
27
02
2023
revised:
29
03
2023
accepted:
04
04
2023
medline:
14
4
2023
entrez:
13
4
2023
pubmed:
14
4
2023
Statut:
epublish
Résumé
Dysfunction of the complex cerebral networks underlying wakefulness and awareness is responsible for Disorders of Consciousness (DoC). Traumatic Brain Injury (TBI) is a common cause of DoC, and it is responsible for a multi-dimensional pathological cascade that affects the proper functioning of the brainstem and brain consciousness pathways. Iron (Fe), Zinc (Zn), and Copper (Cu) have a role in the neurophysiology of both the ascending reticular activating system, a multi-neurotransmitter network located in the brainstem that is crucial for consciousness, and several brain regions. We aimed to summarize the role of these essential metals in TBI and its possible link with consciousness alterations. We found that TBI alters many neuronal molecular mechanisms involving essential metals, causing neurodegeneration, neural apoptosis, synaptic dysfunction, oxidative stress, and inflammation. This final pattern resembles that described for Alzheimer's disease (AD) and other neurological and psychiatric diseases. Furthermore, we found that amantadine, zolpidem, and transcranial direct current stimulation (tDCS)-the most used treatments for DoC recovery-seem to have an effect on essential metals-related pathways and that Zn might be a promising new therapeutic approach. This review summarizes the neurophysiology of essential metals in the brain structures of consciousness and focuses on the mechanisms underlying their imbalance following TBI, suggesting their possible role in DoC. The scenario supports further studies aimed at getting a deeper insight into metals' role in DoC, in order to evaluate metal-based drugs, such as metal complexes and metal chelating agents, as potential therapeutic options.
Identifiants
pubmed: 37047843
pii: ijms24076867
doi: 10.3390/ijms24076867
pmc: PMC10095508
pii:
doi:
Substances chimiques
Metals
0
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Alzheimer's Association
ID : Part the Cloud: Translational Research Funding for Alzheimer's Disease (PTC) PTC-19-602325
Pays : United States
Références
J Inorg Biochem. 2019 Oct;199:110770
pubmed: 31336257
Brain Res. 2002 Sep 13;949(1-2):32-41
pubmed: 12213297
J Neurotrauma. 2015 Jan 1;32(1):58-65
pubmed: 25058115
Antioxidants (Basel). 2022 Jul 22;11(8):
pubmed: 35892623
Curr Alzheimer Res. 2021;18(7):533-545
pubmed: 34674622
Int J Clin Exp Med. 2015 May 15;8(5):8042-50
pubmed: 26221369
Cell Mol Life Sci. 2014 Sep;71(17):3281-95
pubmed: 24710731
J Nutr. 2000 May;130(5S Suppl):1471S-83S
pubmed: 10801962
J Neurochem. 1999 Feb;72(2):741-50
pubmed: 9930748
Ann Clin Biochem. 2003 Mar;40(Pt 2):115-21
pubmed: 12662398
J Neurochem. 1995 Jan;64(1):307-15
pubmed: 7798927
J Biol Chem. 2002 Nov 22;277(47):45518-28
pubmed: 12198135
J Neurosci. 2012 Nov 21;32(47):16857-71a
pubmed: 23175838
J Alzheimers Dis. 2019;68(2):493-510
pubmed: 30883346
Nat Med. 2012 Jan 29;18(2):291-5
pubmed: 22286308
Metab Brain Dis. 2015 Apr;30(2):411-26
pubmed: 24771110
Nat Med. 2011 Nov 07;17(11):1391-401
pubmed: 22064429
Neurobiol Aging. 2020 May;89:142.e9-142.e12
pubmed: 32143980
J Alzheimers Dis. 2008 May;14(1):69-84
pubmed: 18525129
Radiology. 2020 Sep;296(3):619-626
pubmed: 32602825
Exp Neurol. 2013 Aug;246:35-43
pubmed: 22285252
PLoS Pathog. 2015 May 07;11(5):e1004745
pubmed: 25951168
Biol Psychol. 1997 Mar 21;45(1-3):57-71
pubmed: 9083644
Nat Rev Neurol. 2014 Feb;10(2):99-114
pubmed: 24468878
Metallomics. 2018 Mar 1;10(3):397-405
pubmed: 29384550
J Head Trauma Rehabil. 2005 Nov-Dec;20(6):475-87
pubmed: 16304485
J Nerv Ment Dis. 1953 Aug;118(2):97-130
pubmed: 13109530
Pharmacol Rep. 2016 Apr;68(2):443-50
pubmed: 26922551
Science. 1996 Apr 12;272(5259):225-6
pubmed: 8602506
Science. 1999 Oct 22;286(5440):735-41
pubmed: 10531052
AJNR Am J Neuroradiol. 2011 Nov-Dec;32(10):1851-6
pubmed: 21885717
Front Neurosci. 2021 Mar 16;15:587197
pubmed: 33796002
Neuropharmacology. 2009 Jan;56(1):198-207
pubmed: 18674547
J Coll Physicians Surg Pak. 2018 Jun;28(6):456-559
pubmed: 29848423
J Neurol Neurosurg Psychiatry. 1994 Apr;57(4):419-25
pubmed: 8163989
J Physiol. 2002 Aug 15;543(Pt 1):35-48
pubmed: 12181280
Cell Mol Life Sci. 2014 May;71(9):1607-22
pubmed: 24218010
Prog Neurobiol. 1994 Feb;42(3):393-441
pubmed: 7520185
Neuroscience. 2009 Jan 12;158(1):126-36
pubmed: 18353558
Biomolecules. 2022 Sep 06;12(9):
pubmed: 36139084
Am J Med Genet B Neuropsychiatr Genet. 2003 May 15;119B(1):48-53
pubmed: 12707938
J Alzheimers Dis. 2021;83(1):23-41
pubmed: 34219710
Mol Neurobiol. 2014 Oct;50(2):534-44
pubmed: 24567119
J Neurosci. 2007 Feb 28;27(9):2349-56
pubmed: 17329432
Neurol Sci. 2013 Jul;34(7):1173-80
pubmed: 23079850
Pharmacol Rep. 2013;65(6):1558-71
pubmed: 24553004
Brain. 2017 Aug 1;140(8):2112-2119
pubmed: 28899019
Pharmacol Rep. 2015 Apr;67(2):187-94
pubmed: 25712638
Trends Neurosci. 2016 May;39(5):311-324
pubmed: 27040729
Rev Neurosci. 2020 Apr 28;31(3):233-243
pubmed: 31747384
AACN Adv Crit Care. 2021 Mar 15;32(1):29-50
pubmed: 33725106
J Pak Med Assoc. 1989 Oct;39(10):269-74
pubmed: 2513424
J Neurosci. 2001 Feb 15;21(4):1179-88
pubmed: 11160388
EBioMedicine. 2018 Feb;28:21-30
pubmed: 29396300
Circ Res. 2016 Oct 28;119(10):1052-1054
pubmed: 27789581
Neurobiol Dis. 2020 Jun;139:104810
pubmed: 32087292
JAMA Neurol. 2017 Jan 1;74(1):122-125
pubmed: 27893873
Curr Neuropharmacol. 2016;14(4):392-402
pubmed: 26714583
Science. 2002 Jul 19;297(5580):353-6
pubmed: 12130773
Neuroimage. 2019 May 1;191:176-185
pubmed: 30739060
J Nutr Biochem. 2014 Nov;25(11):1101-1107
pubmed: 25154570
Brain Sci. 2016 Feb 17;6(1):
pubmed: 26901230
Acta Neuropathol. 2009 May;117(5):557-67
pubmed: 19221770
PLoS One. 2010 Apr 09;5(4):e10131
pubmed: 20396380
Neurosci Biobehav Rev. 2016 Sep;68:460-473
pubmed: 27181909
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):693-701
pubmed: 20156515
J Neurol Sci. 2021 Feb 15;421:117253
pubmed: 33476985
Proc Natl Acad Sci U S A. 2005 May 10;102(19):6843-8
pubmed: 15863613
Redox Biol. 2018 Apr;14:450-464
pubmed: 29080524
Mol Neurobiol. 2022 Jun;59(6):3703-3720
pubmed: 35366734
Science. 2001 Aug 24;293(5534):1449-54
pubmed: 11520976
Acta Neuropathol Commun. 2017 Apr 18;5(1):30
pubmed: 28420443
J Neurosurg. 1992 Jan;76(1):119-26
pubmed: 1727149
Antioxid Redox Signal. 2012 Jun 15;16(12):1421-33
pubmed: 22229260
Cold Spring Harb Symp Quant Biol. 1987;52:473-82
pubmed: 3135979
Acta Neuropathol Commun. 2020 Apr 7;8(1):45
pubmed: 32264976
Brain Pathol. 2015 May;25(3):350-64
pubmed: 25904048
J Neurol Sci. 1998 Jun 11;158(1):47-52
pubmed: 9667777
J Biol Chem. 2015 Jul 10;290(28):17415-38
pubmed: 26018073
Nature. 1998 Jan 22;391(6665):387-90
pubmed: 9450754
Int J Mol Sci. 2015 Aug 19;16(8):19657-70
pubmed: 26295390
J Head Trauma Rehabil. 1998 Aug;13(4):24-39
pubmed: 9651237
Front Neurosci. 2018 Mar 22;12:163
pubmed: 29623026
Biochem Biophys Res Commun. 2009 Feb 27;380(1):198-203
pubmed: 19171119
Exp Neurol. 2007 Dec;208(2):185-92
pubmed: 17826768
Brain Res. 2007 Jan 5;1127(1):119-26
pubmed: 17109824
Exp Biol Med (Maywood). 2018 May;243(9):780-785
pubmed: 29763364
AIDS Patient Care STDS. 2000 Oct;14(10):533-9
pubmed: 11054937
Curr Opin Gastroenterol. 2009 Mar;25(2):136-43
pubmed: 19528881
J Neuroinflammation. 2012 Jul 23;9:179
pubmed: 22824372
J Neurochem. 2000 Jan;74(1):270-9
pubmed: 10617129
J Biol Chem. 2001 Dec 14;276(50):47524-9
pubmed: 11595748
J Biol Inorg Chem. 2019 Dec;24(8):1179-1188
pubmed: 31691104
N Engl J Med. 1999 Dec 23;341(26):1986-95
pubmed: 10607817
Neurobiol Aging. 2004 Apr;25(4):465-74
pubmed: 15013567
Clin Nutr. 2022 Jun;41(6):1357-1424
pubmed: 35365361
Front Aging Neurosci. 2021 Feb 18;13:617588
pubmed: 33679375
Autophagy. 2016 Sep;12(9):1487-506
pubmed: 27383256
J Cell Mol Med. 2019 Apr;23(4):2995-3009
pubmed: 30756474
Neuroreport. 1993 Sep 10;4(11):1269-71
pubmed: 8219026
Mol Pharm. 2021 Feb 1;18(2):593-609
pubmed: 32926630
Dis Markers. 2006;22(1-2):95-102
pubmed: 16410654
J Neurosurg. 1986 Feb;64(2):224-30
pubmed: 3944632
Neurology. 2014 Apr 1;82(13):1112-8
pubmed: 24574549
Acta Neuropathol. 2001 May;101(5):417-23
pubmed: 11484812
Med Sci (Basel). 2020 Aug 17;8(3):
pubmed: 32824524
Nat Rev Neurol. 2021 Mar;17(3):135-156
pubmed: 33318675
J Neurosurg. 2003 May;98(5):1072-7
pubmed: 12744368
Biochem Biophys Res Commun. 2004 Sep 10;322(1):232-8
pubmed: 15313196
Oxid Med Cell Longev. 2013;2013:726954
pubmed: 23710288
Mol Psychiatry. 2021 Oct;26(10):5481-5503
pubmed: 34456336
Neurosci Lett. 2008 Aug 1;440(2):155-9
pubmed: 18556117
Brain Res. 2000 Jan 10;852(2):268-73
pubmed: 10678752
J Biol Chem. 2007 Aug 17;282(33):24373-80
pubmed: 17565998
FEBS Lett. 2000 Oct 13;483(1):6-10
pubmed: 11033346
Biochemistry. 1999 Jun 15;38(24):7609-16
pubmed: 10386999
J Neurosurg. 2010 Sep;113(3):556-63
pubmed: 19852541
Neurobiol Aging. 2001 Jul-Aug;22(4):563-8
pubmed: 11445256
Metallomics. 2016 Feb;8(2):193-200
pubmed: 26689359
Molecules. 2020 Oct 20;25(20):
pubmed: 33092205
Nutr Metab Insights. 2011 Feb 07;4:1-5
pubmed: 23946656
Science. 2012 Oct 5;338(6103):68-72
pubmed: 23042884
Antioxidants (Basel). 2021 Sep 16;10(9):
pubmed: 34573112
Annu Rev Nutr. 2009;29:133-52
pubmed: 19400701
J Neurochem. 2002 Sep;82(5):1137-47
pubmed: 12358761
J Neuropsychiatry Clin Neurosci. 1994 Fall;6(4):358-70
pubmed: 7841807
Neuropsychiatr Dis Treat. 2008 Aug;4(4):797-816
pubmed: 19043523
Nanoscale. 2018 Jul 5;10(25):11782-11796
pubmed: 29688240
Behav Brain Res. 2015;287:323-30
pubmed: 25845739
Proc Nutr Soc. 1989 Sep;48(3):347-54
pubmed: 2482490
Mol Psychiatry. 2006 Feb;11(2):134-42
pubmed: 16205735
J Neurosci. 2004 Nov 3;24(44):9903-13
pubmed: 15525775
Sci Rep. 2016 Feb 22;6:21970
pubmed: 26898550
Neurobiol Aging. 2019 Aug;80:46-55
pubmed: 31102901
Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9866-8
pubmed: 9275217
J Med Genet. 2004 Apr;41(4):261-5
pubmed: 15060098
J Neuropsychiatry Clin Neurosci. 2018 Spring;30(2):91-100
pubmed: 29132272
J Diet Suppl. 2018 Jan 2;15(1):1-10
pubmed: 28467150
Front Cell Neurosci. 2017 Sep 21;11:297
pubmed: 29033788
Dement Geriatr Cogn Disord. 2003;15(3):151-4
pubmed: 12584430
BMC Psychiatry. 2013 Jun 04;13:161
pubmed: 23735056
J Trace Elem Med Biol. 2012 Jun;26(2-3):66-9
pubmed: 22664333
Front Cell Neurosci. 2015 Aug 17;9:322
pubmed: 26347610
Neurosci Biobehav Rev. 2015 Apr;51:164-88
pubmed: 25625874
Lancet. 1991 Jun 1;337(8753):1304-8
pubmed: 1674295
J Neuropsychiatry Clin Neurosci. 2018 Fall;30(4):262-270
pubmed: 29939106
Neurobiol Dis. 2019 Apr;124:335-339
pubmed: 30557658
Exp Neurol. 2016 May;279:96-103
pubmed: 26902472
Biochem Biophys Res Commun. 2017 Feb 19;483(4):1143-1147
pubmed: 27639648
J Biol Chem. 2019 Mar 15;294(11):4202-4214
pubmed: 30647129
Exp Biol Med (Maywood). 2021 Mar;246(5):607-616
pubmed: 33653183
Brain Stimul. 2017 Nov - Dec;10(6):1079-1087
pubmed: 28870510
J Neurosurg. 2018 Apr 1;:1-18
pubmed: 29701556
Nature. 2009 Feb 26;457(7233):1128-32
pubmed: 19242475
Acc Chem Res. 2014 Aug 19;47(8):2252-9
pubmed: 24871565
Alzheimers Dement. 2021 Jul;17(7):1244-1256
pubmed: 33491917
Neuroscience. 2021 Mar 1;457:235-258
pubmed: 33460731
N Engl J Med. 2012 Mar 1;366(9):819-26
pubmed: 22375973
Biochemistry. 2018 Jul 17;57(28):4165-4176
pubmed: 29894164
J Neurol Neurosurg Psychiatry. 2018 May;89(5):456-460
pubmed: 28939683
Brain Res. 2009 Jan 12;1248:14-21
pubmed: 19014916
Neurochem Int. 2006 Dec;49(8):746-50
pubmed: 16901589
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16770-5
pubmed: 12481036
J Neurosci Res. 1992 Feb;31(2):327-35
pubmed: 1573683
J Neurosci. 1988 Jun;8(6):2164-71
pubmed: 3385493
Physiol Behav. 2011 Oct 24;104(5):942-7
pubmed: 21699908
J Neurochem. 2011 Oct;119(1):78-88
pubmed: 21824141
Neurology. 1995 Feb;45(2):397
pubmed: 7710535
Neuron. 2013 Nov 20;80(4):844-66
pubmed: 24267647
Am J Phys Med Rehabil. 2014 Feb;93(2):101-13
pubmed: 24434886
Biomolecules. 2021 Jun 29;11(7):
pubmed: 34209820
Circulation. 2017 Aug 22;136(8):719-728
pubmed: 28588075
Vet Res. 2008 Jul-Aug;39(4):9
pubmed: 18073096
J Neurosci Res. 1992 Jan;31(1):75-83
pubmed: 1613823
J Neurosci. 1994 Oct;14(10):5844-57
pubmed: 7931547
Acta Pharmacol Sin. 2018 Feb;39(2):177-183
pubmed: 28836584
Front Psychol. 2017 May 05;8:634
pubmed: 28529492
FASEB J. 1988 Oct;2(13):2884-90
pubmed: 2458983
J Neurotrauma. 1996 Jan;13(1):25-34
pubmed: 8714860
J Neurochem. 1960 Jun;5:307-10
pubmed: 14399117
Brain. 2021 Feb 12;144(1):18-31
pubmed: 33186462
J Neurosci Res. 2003 May 15;72(4):537-42
pubmed: 12704815
J Nutr. 2009 Sep;139(9):1626-31
pubmed: 19625698
EMBO J. 1994 Jun 1;13(11):2516-25
pubmed: 8013452
Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1716-21
pubmed: 9990090
Neuroimage Clin. 2015 Nov 10;10:27-35
pubmed: 26693399
Curr Opin Crit Care. 2002 Apr;8(2):101-5
pubmed: 12386508
Cell Mol Neurobiol. 2016 Mar;36(2):241-58
pubmed: 26988697
Int J Alzheimers Dis. 2011;2011:864753
pubmed: 22028985
Proc Natl Acad Sci U S A. 2000 May 23;97(11):5690-2
pubmed: 10823929
Biol Trace Elem Res. 2016 Dec;174(2):287-293
pubmed: 27147437
Nat Rev Neurosci. 2019 Oct;20(10):593-608
pubmed: 31492945
Cell. 2012 May 25;149(5):1060-72
pubmed: 22632970
Free Radic Biol Med. 2003 May 15;34(10):1243-52
pubmed: 12726912
Front Neurosci. 2018 Sep 10;12:632
pubmed: 30250423
Nat Commun. 2015 May 19;6:6760
pubmed: 25988319