HAT1: Landscape of Biological Function and Role in Cancer.
HAT1
acetylation
cancer
epigenetics
inflammation
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 04 2023
02 04 2023
Historique:
received:
13
03
2023
revised:
31
03
2023
accepted:
01
04
2023
medline:
14
4
2023
entrez:
13
4
2023
pubmed:
14
4
2023
Statut:
epublish
Résumé
Histone modifications, as key chromatin regulators, play a pivotal role in the pathogenesis of several diseases, such as cancer. Acetylation, and more specifically lysine acetylation, is a reversible epigenetic process with a fundamental role in cell life, able to target histone and non-histone proteins. This epigenetic modification regulates transcriptional processes and protein activity, stability, and localization. Several studies highlight a specific role for HAT1 in regulating molecular pathways, which are altered in several pathologies, among which is cancer. HAT1 is the first histone acetyltransferase discovered; however, to date, its biological characterization is still unclear. In this review, we summarize and update the current knowledge about the biological function of this acetyltransferase, highlighting recent advances of HAT1 in the pathogenesis of cancer.
Identifiants
pubmed: 37048148
pii: cells12071075
doi: 10.3390/cells12071075
pmc: PMC10092946
pii:
doi:
Substances chimiques
Chromatin
0
Histone Acetyltransferases
EC 2.3.1.48
Histones
0
histone acetyltransferase type B complex
EC 2.3.1.48
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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