Are We on the Right Track for HCV Micro-Elimination? HCV Management Practices in Dialysis Centers in Poland-A National Cross-Sectional Survey.

Direct Acting Antivirals (DAA) eradication of infection hepatitis C virus (HCV)

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
04 Apr 2023
Historique:
received: 15 03 2023
revised: 02 04 2023
accepted: 03 04 2023
medline: 14 4 2023
entrez: 13 4 2023
pubmed: 14 4 2023
Statut: epublish

Résumé

Chronic hepatitis C (CHC) is prevalent in the hemodialysis-dependent population. Currently, all patients with CHC should be considered for treatment; however, many hemodialysis-dependent patients are still left untreated. Following HCV cure, accurate surveillance is mandatory to reduce liver-related mortality and prevent reinfection. We aimed to establish HCV management practices and barriers to HCV elimination in dialysis centers in Poland. Polish dialysis centers were surveyed via email. The HCV management strategies were investigated. Representatives of 112 dialysis centers responded, representing 43.1% of all dialysis centers in Poland and 43.4% of hemodialysis-dependent patients' volume. Most respondents were Heads of hemodialysis centers and board-certified nephrologists. The study demonstrated that in the vast majority of hemodialysis centers (91.6%), subjects are considered for antiviral treatment (AVT); however, many obstacles preventing patients from being prescribed AVT were identified; patients' reluctance to undergo AVT was most reported (60%). The majority of dialysis units neither evaluate patients with CHC for liver fibrosis (60.4%) nor screen them for hepatocellular carcinoma (53.5%). In conclusion, the presented study demonstrates that HCV management practices across Polish dialysis centers vary substantially. There is a need to optimize and streamline the HCV management infrastructure in the hemodialysis population in Poland.

Identifiants

pubmed: 37048794
pii: jcm12072711
doi: 10.3390/jcm12072711
pmc: PMC10095141
pii:
doi:

Types de publication

Journal Article

Langues

eng

Références

Lancet Gastroenterol Hepatol. 2022 May;7(5):396-415
pubmed: 35180382
Przegl Epidemiol. 2020;74(2):209-222
pubmed: 33112105
Lancet Gastroenterol Hepatol. 2017 Mar;2(3):161-176
pubmed: 28404132
Am J Infect Control. 2009 Jun;37(5):403-407
pubmed: 18945513
J Hepatol. 2020 Nov;73(5):1170-1218
pubmed: 32956768
Ren Fail. 2022 Dec;44(1):434-449
pubmed: 35260039
Antivir Ther. 2010;15(3):281-91
pubmed: 20516548
Kidney Int. 2022 Dec;102(6S):S129-S205
pubmed: 36410841
Lancet Gastroenterol Hepatol. 2019 Feb;4(2):135-184
pubmed: 30647010
Am J Nephrol. 2015;41(4-5):302
pubmed: 26044708
Pathogens. 2021 Sep 07;10(9):
pubmed: 34578181
Semin Dial. 2018 Jan;31(1):26-36
pubmed: 28925068
Dig Dis Sci. 2013 Dec;58(12):3620-5
pubmed: 24154637
Sci Rep. 2021 Jun 3;11(1):11681
pubmed: 34083617
Nephrol Dial Transplant. 1996;11 Suppl 4:36-8
pubmed: 8918750
Clin J Am Soc Nephrol. 2012 Apr;7(4):549-57
pubmed: 22403269
Clin Transplant. 2012 Mar-Apr;26(2):247-53
pubmed: 21554396
J Viral Hepat. 2014 Dec;21(12):930-7
pubmed: 24472062
Am J Kidney Dis. 2001 May;37(5):1004-10
pubmed: 11325683
Ann Intern Med. 2017 Sep 5;167(5):311-318
pubmed: 28785771
Clin Gastroenterol Hepatol. 2018 Jan;16(1):27-38.e4
pubmed: 28479504
Infect Control Hosp Epidemiol. 2011 May;32(5):415-24
pubmed: 21515970

Auteurs

Paulina Czarnecka (P)

Department of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, Poland.

Kinga Czarnecka (K)

Department of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, Poland.

Olga Tronina (O)

Department of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, Poland.

Teresa Baczkowska (T)

Department of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, Poland.

Weronika Zarychta-Wisniewska (W)

Department of Immunology, Transplant Medicine and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, Poland.

Magdalena Durlik (M)

Department of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, Poland.

Classifications MeSH