A Low Daily Intake of Simple Sugars in the Diet Is Associated with Improved Liver Function in Cirrhotic Liver Transplant Candidates.

DELTA-MELD cirrhosis cirrhotic diet liver transplant simple sugars visceral adipose tissue

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
24 Mar 2023
Historique:
received: 28 02 2023
revised: 19 03 2023
accepted: 21 03 2023
medline: 14 4 2023
entrez: 13 4 2023
pubmed: 14 4 2023
Statut: epublish

Résumé

(1) Background: We investigated, for the first time, whether dietary simple sugar intake affects MELD score changes over time in a cohort of cirrhotic liver transplant candidates. (2) Methods: the MELD score, dietary habits using a 3-day food diary, and visceral adipose tissue index (VATI) measured with CT scan were assessed in 80 consecutive outpatient cirrhotic patients at baseline, after counseling to follow current nutritional guidelines. The MELD score was reassessed after six months and the DELTA-MELD was calculated as the MELD at the second assessment minus the MELD at baseline. (3) Results: Compared with the baseline, the MELD score of cirrhotic patients at the end of the study was decreased, stable, or increased in 36%, 8% and 56% of patients, respectively. In separate multiple linear regression models, DELTA-MELD was positively and independently correlated with the daily intake of simple sugars expressed in g/kg body weight (

Identifiants

pubmed: 37049416
pii: nu15071575
doi: 10.3390/nu15071575
pmc: PMC10097197
pii:
doi:

Substances chimiques

Monosaccharides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Simona Parisse (S)

Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.

Sara Carnevale (S)

Belcolle Hospital, 01100 Viterbo, Italy.

Francesca Di Bartolomeo (F)

Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.

Edoardo Poli (E)

Centre Hépato-Biliaire, Hôpital Paul Brousse, AP-HP, 94800 Villejuif, France.

Francesca Miceli (F)

Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.

Flaminia Ferri (F)

Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.

Monica Mischitelli (M)

Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.

Bianca Rocco (B)

Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, 00161 Rome, Italy.

Quirino Lai (Q)

General Surgery and Organ Transplantation Unit, Department of Surgery, Sapienza University of Rome, 00161 Rome, Italy.

Pierleone Lucatelli (P)

Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, 00161 Rome, Italy.

Mario Corona (M)

Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, 00161 Rome, Italy.

Gianluca Mennini (G)

General Surgery and Organ Transplantation Unit, Department of Surgery, Sapienza University of Rome, 00161 Rome, Italy.

Adriano De Santis (A)

Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.

Massimo Rossi (M)

General Surgery and Organ Transplantation Unit, Department of Surgery, Sapienza University of Rome, 00161 Rome, Italy.

Maurizio Muscaritoli (M)

Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.

Alfredo Cantafora (A)

Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.

Stefano Ginanni Corradini (S)

Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.

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