In Vitro Effect of Enzymes and Human Milk Oligosaccharides on FODMAP Digestion and Fecal Microbiota Composition.
FODMAP
digestive enzymes
human milk oligosaccharide
inflammatory bowel syndrome
invertase
α-galactosidase
β-galactosidase
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
28 Mar 2023
28 Mar 2023
Historique:
received:
23
12
2022
revised:
15
01
2023
accepted:
07
02
2023
medline:
14
4
2023
entrez:
13
4
2023
pubmed:
14
4
2023
Statut:
epublish
Résumé
Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) cause intestinal discomfort in patients with irritable bowel syndrome (IBS). An enzyme mix (2500 SU invertase, 2400 GalU α-galactosidase, 10,000 ALU β-galactosidase) optimized for FODMAP digestion, and/or human milk oligosaccharides (HMO) (2'-FL, DFL, and LNnT), were evaluated for effects on microbial community activity and composition in short-term colonic incubations using the fecal microbiota of four patients with IBS-D symptoms under the following test conditions: (i) FODMAP, (ii) pre-digested (with enzyme mix) FODMAP, (iii) FODMAP + HMO, and (iv) pre-digested FODMAP + HMO. Pre-digested FODMAP reduced short-chain fatty acid (SCFA) production versus FODMAP; HMO restored this. A 10-day experiment with the simulator of the human intestinal microbial ecosystem (SHIME
Identifiants
pubmed: 37049481
pii: nu15071637
doi: 10.3390/nu15071637
pmc: PMC10097142
pii:
doi:
Substances chimiques
Oligosaccharides
0
Fatty Acids, Volatile
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : DSM
ID : Company funds
Références
Nucleic Acids Res. 2013 Jan 7;41(1):e1
pubmed: 22933715
J Crohns Colitis. 2009 Feb;3(1):8-14
pubmed: 21172242
FEMS Microbiol Ecol. 2010 Dec;74(3):601-11
pubmed: 20946352
Nutrients. 2020 Jun 29;12(7):
pubmed: 32610452
J Microbiol Methods. 2013 Aug;94(2):73-76
pubmed: 23684992
Gut. 2017 Jun;66(6):1075-1082
pubmed: 26818616
Biotechnol J. 2019 May;14(5):e1800555
pubmed: 30791234
Nutrients. 2020 Sep 13;12(9):
pubmed: 32933181
ACS Omega. 2018 Oct 31;3(10):12446-12456
pubmed: 30411009
Front Microbiol. 2016 Jun 15;7:925
pubmed: 27379055
Neurogastroenterol Motil. 2018 Jan;30(1):
pubmed: 28707437
Am J Gastroenterol. 2021 Jan 1;116(1):17-44
pubmed: 33315591
Curr Drug Metab. 2016;17(2):187-93
pubmed: 26806042
Aliment Pharmacol Ther. 2018 Jul;48(1):15-34
pubmed: 29722430
World J Gastroenterol. 2016 Apr 21;22(15):4009-19
pubmed: 27099444
Neurogastroenterol Motil. 2020 Oct;32(10):e13920
pubmed: 32536023
Aliment Pharmacol Ther. 2010 Apr;31(8):874-82
pubmed: 20102355
Inflamm Bowel Dis. 2009 Aug;15(8):1183-9
pubmed: 19235886
J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:23-26
pubmed: 28244661
Nutrients. 2020 Jan 04;12(1):
pubmed: 31947991
Aliment Pharmacol Ther. 2005 Jun 15;21(12):1399-409
pubmed: 15948806
J Hum Nutr Diet. 2016 Oct;29(5):549-75
pubmed: 27272325
Environ Microbiol. 2017 Aug;19(8):3251-3267
pubmed: 28618173
Clin Nutr. 2019 Apr;38(2):697-707
pubmed: 29653862
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6
pubmed: 18936492
Microorganisms. 2020 Nov 01;8(11):
pubmed: 33139627
Gastroenterology. 2017 Jan;152(1):124-133.e2
pubmed: 27746233
J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:8-10
pubmed: 28244669
Am J Gastroenterol. 2013 May;108(5):707-17
pubmed: 23588241
Benef Microbes. 2014 Sep;5(3):273-83
pubmed: 24913838
Aliment Pharmacol Ther. 2020 Jul;52(2):233-246
pubmed: 32562590
J Gastroenterol Hepatol. 2010 Aug;25(8):1366-73
pubmed: 20659225
Microorganisms. 2020 Apr 15;8(4):
pubmed: 32326636
Clin Transl Gastroenterol. 2020 Dec;11(12):e00276
pubmed: 33512807
J Nutr. 2012 Aug;142(8):1510-8
pubmed: 22739368
Clin Transl Gastroenterol. 2016 Apr 14;7:e164
pubmed: 27077959
J Gastroenterol Hepatol. 2010 Feb;25(2):252-8
pubmed: 20136989
Gut. 2015 Jan;64(1):93-100
pubmed: 25016597
Gastroenterol Res Pract. 2014;2014:872725
pubmed: 24799893
FEMS Microbiol Ecol. 2004 Sep 1;49(3):495-507
pubmed: 19712298
EBioMedicine. 2015 Jul 10;2(8):968-84
pubmed: 26425705
Am J Gastroenterol. 2014 Jan;109(1):110-9
pubmed: 24247211
Appl Microbiol Biotechnol. 1993 May;39(2):254-8
pubmed: 7763732