Long-term stability of infrabony defects treated with enamel matrix derivative alone: A retrospective two-centre cohort study.
Humans
Female
Middle Aged
Treatment Outcome
Follow-Up Studies
Retrospective Studies
Tooth Loss
/ surgery
Cohort Studies
Periodontal Pocket
/ surgery
Alveolar Bone Loss
/ surgery
Gingival Recession
/ surgery
Dental Enamel Proteins
/ therapeutic use
Guided Tissue Regeneration, Periodontal
/ methods
Periodontal Attachment Loss
/ surgery
enamel matrix derivates
guided tissue regeneration
longitudinal studies
periodontal
tooth loss
Journal
Journal of clinical periodontology
ISSN: 1600-051X
Titre abrégé: J Clin Periodontol
Pays: United States
ID NLM: 0425123
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
05
03
2023
received:
16
01
2023
accepted:
27
03
2023
medline:
12
6
2023
pubmed:
14
4
2023
entrez:
13
4
2023
Statut:
ppublish
Résumé
To assess the long-term stability of attachment gain in infrabony defects (IBDs) 10 years after regenerative treatment with an enamel matrix derivative (EMD) alone. Two centres (Frankfurt [F] and Heidelberg [HD]) invited patients for re-examination 120 ± 12 months after regenerative therapy. Re-examination included clinical examination (periodontal probing depths (PPD), vertical clinical attachment level (CAL), plaque index (PlI), gingival index (GI), plaque control record, gingival bleeding index and periodontal risk assessment) and review of patient charts (number of supportive periodontal care [SPC] visits). Both centres included 52 patients (29 female; median baseline age: 52.0 years; lower/upper quartile: 45.0/58.8 years; eight smokers), each contributing one IBD. Nine teeth were lost. For the remaining 43 teeth, regenerative therapy showed significant CAL gain after 1 year (3.0; 2.0/4.4 mm; p < .001) and 10 years (3.0; 1.5/4.1 mm; p < .001) during which CAL remained stable (-0.5; -1.0/1.0 mm; p = 1.000) after an average SPC of 9 years. Mixed-model regression analyses revealed a positive association of CAL gain from 1 to 10 years with CAL 12 months post operation (logistic: p = .01) as well as a higher probability for CAL loss with an increasing vertical extent of a three-walled defect component (linear: p = .008). Cox proportional hazard analysis showed a positive association between PlI after 12 months and tooth loss (p = .046). Regenerative therapy of IBDs showed stable results over 9 years. CAL gain is associated with CAL after 12 months and decreasing initial defect depth in a three-walled defect morphology. Tooth loss is associated with PlI 12 months post operation. DRKS00021148 (URL: https://drks.de).
Substances chimiques
enamel matrix proteins
0
Dental Enamel Proteins
0
Banques de données
DRKS
['DRKS00021148']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
996-1009Informations de copyright
© 2023 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.
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