Infection of Endothelial Cells with Acinetobacter baumannii Reveals Remodelling of Mitochondrial Protein Complexes.

Humans Acinetobacter baumannii / genetics Endothelial Cells Acinetobacter Infections / drug therapy Drug Resistance, Multiple, Bacterial / genetics Anti-Bacterial Agents / pharmacology Mitochondrial Proteins / therapeutic use
Acinetobacter baumannii Galleria mellonella host-pathogen interaction infection international cluster 2 (IC2) mitochondria oxidative phosphorylation virulence genes

Journal

Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614

Informations de publication

Date de publication:
15 06 2023
Historique:
medline: 19 6 2023
pubmed: 14 4 2023
entrez: 13 4 2023
Statut: ppublish

Résumé

Acinetobacter baumannii is an antibiotic-resistant, Gram-negative pathogen that causes a multitude of nosocomial infections. However, pathogenicity mechanisms and the host cell response during infection remain unclear. In this study, we determined virulence traits of A. baumannii clinical isolates belonging to the most widely disseminated international clonal lineage, international cluster 2 (IC2),

Identifiants

DOI: 10.1128/spectrum.05174-22 PMID: 37052493 PMC: PMC10269660
pubmed: 37052493
doi: 10.1128/spectrum.05174-22
pmc: PMC10269660
doi:

Substances chimiques

Anti-Bacterial Agents 0
Mitochondrial Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0517422

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Laura Leukert (L)

Institute for Medical Microbiology and Infection Control, University Hospital, Goethe University, Frankfurt am Main, Germany.

Manuela Tietgen (M)

Institute for Medical Microbiology and Infection Control, University Hospital, Goethe University, Frankfurt am Main, Germany.
University Center of Competence for Infection Control of the State of Hesse, Frankfurt am Main, Germany.

Felix F Krause (FF)

Institute for Medical Microbiology and Infection Control, University Hospital, Goethe University, Frankfurt am Main, Germany.
Institute for Medical Microbiology and Hygiene, Philipps-University, Marburg, Germany.

Tilman G Schultze (TG)

Institute for Medical Microbiology and Infection Control, University Hospital, Goethe University, Frankfurt am Main, Germany.

Dominik C Fuhrmann (DC)

Institute of Biochemistry I, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany.

Charline Debruyne (C)

Laboratory of Molecular Microbiology and Structural Biochemistry, Centre National de la Recherche Scientifique UMR5086, Université de Lyon, Lyon, France.

Suzana P Salcedo (SP)

Laboratory of Molecular Microbiology and Structural Biochemistry, Centre National de la Recherche Scientifique UMR5086, Université de Lyon, Lyon, France.
ORCID: 0000-0001-5149-7756

Alexander Visekruna (A)

Institute for Medical Microbiology and Hygiene, Philipps-University, Marburg, Germany.

Llka Wittig (L)

Functional Proteomics, Institute of Cardiovascular Physiology, Goethe University, Frankfurt am Main, Germany.

Stephan Göttig (S)

Institute for Medical Microbiology and Infection Control, University Hospital, Goethe University, Frankfurt am Main, Germany.
ORCID: 0000-0001-6896-5309

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Infection of Endothelial Cells with...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Moraxellaceae › Acinetobacter › Acinetobacter baumannii › Infection of Endothelial Cells with...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Infection of Endothelial Cells with...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Moraxellaceae › Infections à Acinetobacter › Infection of Endothelial Cells with...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Multirésistance aux médicaments › Multirésistance bactérienne aux médicaments › Infection of Endothelial Cells with...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Infection of Endothelial Cells with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Infection of Endothelial Cells with...