Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1.

Humans Structure-Activity Relationship Enzyme Inhibitors / chemistry Ethers HeLa Cells Indoleamine-Pyrrole 2,3,-Dioxygenase
Indoleamine 2,3-dioxygenase 1 Medicinal chemistry

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
15 05 2023
Historique:
received: 01 02 2023
revised: 27 03 2023
accepted: 06 04 2023
medline: 8 5 2023
pubmed: 14 4 2023
entrez: 13 4 2023
Statut: ppublish

Résumé

Starting from the dialkylaniline indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor lead 3 (IDO1 HeLa IC

Identifiants

DOI: 10.1016/j.bmcl.2023.129280 PMID: 37054759
pubmed: 37054759
pii: S0960-894X(23)00158-0
doi: 10.1016/j.bmcl.2023.129280
pii:
doi:

Substances chimiques

Enzyme Inhibitors 0
Ethers 0
Indoleamine-Pyrrole 2,3,-Dioxygenase 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

129280

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Jay A Markwalder (JA)

Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States. Electronic address: itr114@gmail.com.

Aaron J Balog (AJ)

Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.

David K Williams (DK)

Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States. Electronic address: david.williams@bms.com.

Susheel J Nara (SJ)

Discovery Chemistry, Biocon Bristol Myers Squibb Research & Development Center, Bangalore, India.

Ratnakar Reddy (R)

Discovery Chemistry, Biocon Bristol Myers Squibb Research & Development Center, Bangalore, India.

Saumya Roy (S)

Former Bristol Myers Squibb Employee, United States.

Yadagiri Kanyaboina (Y)

Discovery Chemistry, Biocon Bristol Myers Squibb Research & Development Center, Bangalore, India.

Xin Li (X)

Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.

Kathy Johnston (K)

Former Bristol Myers Squibb Employee, United States.

Yi Fan (Y)

Former Bristol Myers Squibb Employee, United States.

Hal Lewis (H)

Former Bristol Myers Squibb Employee, United States.

Frank Marsilio (F)

Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.

Chunhong Yan (C)

Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.

David Critton (D)

Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.

John A Newitt (JA)

Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.

Sarah C Traeger (SC)

Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.

Dauh-Rurng Wu (DR)

Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.

Maria N Jure-Kunkel (MN)

Former Bristol Myers Squibb Employee, United States.

Lata Jayaraman (L)

Former Bristol Myers Squibb Employee, United States.

Tai-An Lin (TA)

Former Bristol Myers Squibb Employee, United States.

Michael W Sinz (MW)

Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.

John T Hunt (JT)

Former Bristol Myers Squibb Employee, United States.

Steven P Seitz (SP)

Former Bristol Myers Squibb Employee, United States.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis and biological evaluation of biaryl...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis and biological evaluation of biaryl...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Synthesis and biological evaluation of biaryl...
questionsmedicales.fr › Composés chimiques organiques › Éthers › Synthesis and biological evaluation of biaryl...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › Synthesis and biological evaluation of biaryl...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › Indoleamine-pyrrole 2,3,-dioxygenase › Synthesis and biological evaluation of biaryl...