Shared and distinct abnormalities in sleep-wake patterns and their relationship with the negative symptoms of Schizophrenia Spectrum Disorder patients.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
15
11
2022
accepted:
23
03
2023
revised:
21
03
2023
pubmed:
14
4
2023
medline:
14
4
2023
entrez:
13
4
2023
Statut:
ppublish
Résumé
Sleep and rest-activity-rhythm (RAR) abnormalities are commonly reported in schizophrenia spectrum disorder (SSD) patients. However, an in-depth characterization of sleep/RAR alterations in SSD, including patients in different treatment settings, and the relationship between these alterations and SSD clinical features (e.g., negative symptoms) is lacking. SSD (N = 137 altogether, N = 79 residential and N = 58 outpatients) and healthy control (HC) subjects (N = 113) were recruited for the DiAPAson project. Participants wore an ActiGraph for seven consecutive days to monitor habitual sleep-RAR patterns. Sleep/rest duration, activity (i.e., M10, calculated on the 10 most active hours), rhythm fragmentation within days (i.e., intra-daily variability, IV; beta, steepness of rest-active changes), and rhythm regularity across days (i.e., inter-daily stability, IS) were computed in each study participant. Negative symptoms were assessed in SSD patients with the Brief Negative Symptom Scale (BNSS). Both SSD groups showed lower M10 and longer sleep/rest duration vs. HC, while only residential patients had more fragmented and irregular rhythms than HC. Compared to outpatients, residential patients had lower M10 and higher beta, IV and IS. Furthermore, residential patients had worse BNSS scores relative to outpatients, and higher IS contributed to between-group differences in BNSS score severity. Altogether, residentials and outpatients SSD had both shared and unique abnormalities in Sleep/RAR measures vs. HC and relative to one another, which also contributed to the patients' negative symptom severity. Future work will help establish whether improving some of these measures may ameliorate the quality of life and clinical symptoms of SSD patients.
Identifiants
pubmed: 37055512
doi: 10.1038/s41380-023-02050-x
pii: 10.1038/s41380-023-02050-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2049-2057Subventions
Organisme : NIMH NIH HHS
ID : R01 MH113827
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113827
Pays : United States
Investigateurs
Alessandra Martinelli
(A)
Gabriele Nibbio
(G)
Lorenzo Pelizza
(L)
Rodolfo Pessina
(R)
Roberto Placenti
(R)
Andrea Silva
(A)
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
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