Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial.
Journal
ERJ open research
ISSN: 2312-0541
Titre abrégé: ERJ Open Res
Pays: England
ID NLM: 101671641
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
06
12
2022
accepted:
13
01
2023
medline:
15
4
2023
entrez:
14
4
2023
pubmed:
15
4
2023
Statut:
epublish
Résumé
Cough is the most reported symptom in the United States, with chronic refractory cough representing significant morbidity to patients. Zinc acetate may have beneficial effects in the cough reflex pathway. We sought to assess the safety and efficacy of zinc acetate in the management of chronic refractory cough. This was a randomised, placebo-controlled, parallel-design pilot trial of individuals with chronic refractory cough. The effects of 6 weeks of zinc acetate 34 participants, 17 in each group, were enrolled and randomised. Participants were primarily white females with moderate-severe cough. Participants assigned to zinc acetate had a significant increase in serum zinc levels after 6 weeks, while those assigned to placebo did not. Both groups showed improvement in CQLQ, LCQ, C-VAS and GACC scores, but the treatment effects of zinc acetate We observed no benefit of zinc therapy over placebo on cough symptoms or quality of life and conclude that larger trials of zinc for chronic cough are not warranted.
Sections du résumé
Background
UNASSIGNED
Cough is the most reported symptom in the United States, with chronic refractory cough representing significant morbidity to patients. Zinc acetate may have beneficial effects in the cough reflex pathway. We sought to assess the safety and efficacy of zinc acetate in the management of chronic refractory cough.
Study design and methods
UNASSIGNED
This was a randomised, placebo-controlled, parallel-design pilot trial of individuals with chronic refractory cough. The effects of 6 weeks of zinc acetate
Results
UNASSIGNED
34 participants, 17 in each group, were enrolled and randomised. Participants were primarily white females with moderate-severe cough. Participants assigned to zinc acetate had a significant increase in serum zinc levels after 6 weeks, while those assigned to placebo did not. Both groups showed improvement in CQLQ, LCQ, C-VAS and GACC scores, but the treatment effects of zinc acetate
Interpretation
UNASSIGNED
We observed no benefit of zinc therapy over placebo on cough symptoms or quality of life and conclude that larger trials of zinc for chronic cough are not warranted.
Identifiants
pubmed: 37057088
doi: 10.1183/23120541.00678-2022
pii: 00678-2022
pmc: PMC10086688
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL153778
Pays : United States
Informations de copyright
Copyright ©The authors 2023.
Déclaration de conflit d'intérêts
Conflict of interest: M. Castro reports grant funding from the National Institutes of Health, American Lung Association and the Patient-Centered Outcomes Research Institute, pharmaceutical grant funding from AstraZeneca, GSK, Novartis, Pulmatrix, Sanofi-Aventis, Shionogi, is a consultant for Genentech, Teva, Sanofi-Aventis, Merck, Novartis, a speaker for for Amgen, AstraZeneca, Genentech, GSK, Regeneron, Sanofi-Aventis, Teva, and receives royalties from Elsevier. Conflict of interest: Authors A. Balasubramanian, J.T. Holbrook, B.J. Canning, L.G. Que, B.J. Make, L. Rogers, M.F. Busk, A. Rea, A.A. McCook-Veal, J. He, M.C. McCormack report no conflicts of interest related to this manuscript. Conflict of interest: R.A. Wise reports personal fees for consultation from Merck relevant to the content of this manuscript.
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