Swallowing disorder - A possible therapeutic target for preventing COPD exacerbations.

Dysphagia is a common comorbidity of chronic obstructive pulmonary disease (COPD). In this review article, we show that swallowing disorder can be detected at its early stage as a manifestation of breathing-swallowing discoordination. Furthermore, we provide evidence that low-pressure continuous airway pressure (CPAP) and transcutaneous electrical sensory stimulation using interferential current (IFC-TESS) counteract swallowing disorders and may reduce exacerbations in patients with COPD. Our first prospective study showed that inspiration immediately before or after swallowing is associated with COPD exacerbation. However, the inspiration before swallowing (I-SW) pattern could be interpreted as an airway-protecting behavior. Indeed, the second prospective study showed that the I-SW pattern is more frequently observed in patients who did not experience exacerbations. As potential therapeutic candidates, CPAP normalizes the timing of swallowing, and IFC-TESS applied to the neck acutely facilitates swallowing and chronically improves nutrition and airway protection. Further studies are necessary to elucidate whether such interventions reduce exacerbations in patients with COPD.

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Competing interests The author is a senior managing director at EuSense Medical Co. Ltd.