Human brain microphysiological systems in the study of neuroinfectious disorders.
Brain organoid
Brain spheroid
In-vitro infection
Infection model
Microphysiological system
iPSC
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
06
02
2023
revised:
02
04
2023
accepted:
12
04
2023
pmc-release:
01
07
2024
medline:
22
5
2023
pubmed:
16
4
2023
entrez:
15
4
2023
Statut:
ppublish
Résumé
Microphysiological systems (MPS) are 2D or 3D multicellular constructs able to mimic tissue microenvironments. The latest models encompass a range of techniques, including co-culturing of various cell types, utilization of scaffolds and extracellular matrix materials, perfusion systems, 3D culture methods, 3D bioprinting, organ-on-a-chip technology, and examination of tissue structures. Several human brain 3D cultures or brain MPS (BMPS) have emerged in the last decade. These organoids or spheroids are 3D culture systems derived from induced pluripotent cells or embryonic stem cells that contain neuronal and glial populations and recapitulate structural and physiological aspects of the human brain. BMPS have been introduced recently in the study and modeling of neuroinfectious diseases and have proven to be useful in establishing neurotropism of viral infections, cell-pathogen interactions needed for infection, assessing cytopathological effects, genomic and proteomic profiles, and screening therapeutic compounds. Here we review the different methodologies of organoids used in neuroinfectious diseases including spheroids, guided and unguided protocols as well as microglia and blood-brain barrier containing models, their specific applications, and limitations. The review provides an overview of the models existing for specific infections including Zika, Dengue, JC virus, Japanese encephalitis, measles, herpes, SARS-CoV2, and influenza viruses among others, and provide useful concepts in the modeling of disease and antiviral agent screening.
Identifiants
pubmed: 37061175
pii: S0014-4886(23)00093-6
doi: 10.1016/j.expneurol.2023.114409
pmc: PMC10205672
mid: NIHMS1898044
pii:
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
114409Subventions
Organisme : NINDS NIH HHS
ID : R01 NS110122
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS076381
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Références
Oxid Med Cell Longev. 2022 Dec 5;2022:7264649
pubmed: 36518994
Sci Rep. 2020 Sep 16;10(1):15209
pubmed: 32938988
Stem Cell Res Ther. 2020 Mar 4;11(1):94
pubmed: 32127043
Cell Stem Cell. 2019 Mar 7;24(3):487-497.e7
pubmed: 30799279
Sci Rep. 2019 Feb 5;9(1):1407
pubmed: 30723234
EMBO J. 2020 Oct 15;39(20):e106230
pubmed: 32876341
Pathogens. 2021 Jul 20;10(7):
pubmed: 34358063
Viruses. 2022 Mar 18;14(3):
pubmed: 35337041
Science. 2016 May 13;352(6287):816-8
pubmed: 27064148
Int J Mol Sci. 2021 Jul 25;22(15):
pubmed: 34360696
Int J Mol Sci. 2018 Mar 21;19(4):
pubmed: 29561796
Pathogens. 2021 Nov 19;10(11):
pubmed: 34832665
Tissue Eng Part C Methods. 2015 Dec;21(12):1274-83
pubmed: 26414693
Cell Stem Cell. 2017 Mar 2;20(3):385-396.e3
pubmed: 28041895
Cell Stem Cell. 2017 Aug 3;21(2):274-283.e5
pubmed: 28736217
Cell Stem Cell. 2017 Sep 7;21(3):349-358.e6
pubmed: 28826723
Front Cell Infect Microbiol. 2019 Jul 09;9:223
pubmed: 31338335
Nat Biotechnol. 2020 Dec;38(12):1421-1430
pubmed: 33273741
Nature. 2018 Jan 24;553(7689):437-445
pubmed: 29364288
Cell Stem Cell. 2020 May 7;26(5):766-781.e9
pubmed: 32142682
Viruses. 2022 Dec 15;14(12):
pubmed: 36560802
Nat Microbiol. 2021 Nov;6(11):1398-1409
pubmed: 34675384
Cell Rep Med. 2020 Mar 25;1(1):100002
pubmed: 33205055
Neurobiol Dis. 2022 Jul;169:105719
pubmed: 35398340
Cell Res. 2019 Apr;29(4):265-273
pubmed: 30814679
J Mol Biol. 2022 Feb 15;434(3):167243
pubmed: 34536442
Stem Cell Reports. 2019 May 14;12(5):890-905
pubmed: 31091434
Curr Top Dev Biol. 2021;142:477-530
pubmed: 33706925
Neuropharmacology. 2017 Jul 1;120:63-80
pubmed: 26905292
J Exp Med. 2021 Mar 1;218(3):
pubmed: 33433624
PLoS Biol. 2022 Nov 3;20(11):e3001845
pubmed: 36327326
Front Microbiol. 2018 Dec 04;9:2766
pubmed: 30619100
Nat Commun. 2022 Oct 6;13(1):5688
pubmed: 36202854
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20284-9
pubmed: 24277810
Neuron. 2017 Apr 19;94(2):278-293.e9
pubmed: 28426964
Semin Cell Dev Biol. 2021 Mar;111:4-14
pubmed: 32561297
J Mol Neurosci. 2019 Oct;69(2):286-297
pubmed: 31236774
Nature. 2013 Sep 19;501(7467):373-9
pubmed: 23995685
Heliyon. 2021 Jun 19;7(6):e07350
pubmed: 34195446
Theranostics. 2022 Jul 7;12(12):5317-5329
pubmed: 35910807
ALTEX. 2017;34(3):362-376
pubmed: 27883356
Cell Rep. 2020 Feb 11;30(6):1682-1689.e3
pubmed: 32049002
Front Cell Neurosci. 2019 Sep 20;13:405
pubmed: 31616251
J Neurovirol. 2022 Feb;28(1):17-26
pubmed: 35239145
Development. 2019 Apr 16;146(8):
pubmed: 30992274
Cell Stem Cell. 2016 Aug 4;19(2):258-265
pubmed: 27162029
In Vitro Cell Dev Biol Anim. 2021 Feb;57(2):191-206
pubmed: 33438114
Cell. 2016 May 19;165(5):1238-1254
pubmed: 27118425
Sci Rep. 2020 Jun 24;10(1):10275
pubmed: 32581233
ALTEX. 2021 Dec 09;39:30-70
pubmed: 34882777
Mol Ther Methods Clin Dev. 2020 Jun 01;18:167-175
pubmed: 32637448
Cell Death Differ. 2019 Dec;26(12):2607-2621
pubmed: 30952992
Transl Oncol. 2022 Jan;15(1):101251
pubmed: 34700192
Annu Rev Immunol. 2017 Apr 26;35:441-468
pubmed: 28226226
Rev Med Virol. 2018 May;28(3):e1978
pubmed: 29671914
Nat Neurosci. 2021 Mar;24(3):331-342
pubmed: 33619405
Nat Med. 2016 Oct;22(10):1101-1107
pubmed: 27571349
Front Cell Neurosci. 2020 Feb 21;14:25
pubmed: 32153365
Cell Stem Cell. 2021 Feb 4;28(2):331-342.e5
pubmed: 33450186
Brain. 2021 Oct 22;144(9):2696-2708
pubmed: 33856027
Stem Cell Reports. 2021 Aug 10;16(8):1923-1937
pubmed: 34297942
Cell Stem Cell. 2020 Dec 3;27(6):951-961.e5
pubmed: 33113348
Cell Stem Cell. 2008 Nov 6;3(5):519-32
pubmed: 18983967
J Virol. 2019 Aug 13;93(17):
pubmed: 31217239
Adv Healthc Mater. 2021 Jan;10(2):e2001284
pubmed: 33185040
J Gen Virol. 2010 Apr;91(Pt 4):1028-37
pubmed: 20007359
J Virol. 2019 Aug 13;93(17):
pubmed: 31217241
Nat Commun. 2018 Oct 9;9(1):4167
pubmed: 30301888
ALTEX. 2020 Jun 26;37(4):665-671
pubmed: 32591839
Biomedicines. 2022 Aug 24;10(9):
pubmed: 36140168
Cells. 2021 Dec 05;10(12):
pubmed: 34943930
Nat Rev Neurosci. 2015 Aug;16(8):445-57
pubmed: 26174708
Microbiol Spectr. 2022 Oct 26;10(5):e0169422
pubmed: 36154279
Lab Chip. 2021 Sep 14;21(18):3532-3540
pubmed: 34286713
Int J Mol Sci. 2021 Aug 31;22(17):
pubmed: 34502381
Cells. 2022 Jul 24;11(15):
pubmed: 35892582
Sci Transl Med. 2021 Jan 6;13(575):
pubmed: 33408187
Stem Cells Int. 2021 Sep 9;2021:5902824
pubmed: 34539790
J Virol. 2007 Oct;81(20):10933-49
pubmed: 17670819
Nat Biomed Eng. 2018 Jul;2(7):540-554
pubmed: 30271673
Glia. 2018 Feb;66(2):413-427
pubmed: 29119608
Front Cell Neurosci. 2023 Jan 19;16:1094291
pubmed: 36744062
Methods Mol Biol. 2023;2610:167-178
pubmed: 36534290
Glia. 2020 Oct;68(10):1968-1986
pubmed: 32157745
J Neuroinflammation. 2019 Nov 18;16(1):229
pubmed: 31739796
Part Fibre Toxicol. 2019 Jun 3;16(1):22
pubmed: 31159811
Sci Rep. 2019 Dec 16;9(1):19162
pubmed: 31844087
iScience. 2020 Oct 01;23(10):101633
pubmed: 33103073
Cell Stem Cell. 2016 Aug 4;19(2):248-257
pubmed: 27476966
Cell Death Dis. 2018 Jun 18;9(7):719
pubmed: 29915260
J Neurol Sci. 2021 Aug 15;427:117517
pubmed: 34090021
J Virol. 2019 Apr 17;93(9):
pubmed: 30787148
J Immunol. 2008 Aug 15;181(4):2683-93
pubmed: 18684959
Nat Methods. 2018 Sep;15(9):700-706
pubmed: 30046099
Stem Cells. 2009 Mar;27(3):509-20
pubmed: 19074418
Cell Stem Cell. 2021 Aug 5;28(8):1362-1379.e7
pubmed: 33838105
Cell Rep. 2017 Oct 10;21(2):517-532
pubmed: 29020636
Sci Rep. 2019 Jul 30;9(1):11055
pubmed: 31363137
mBio. 2021 Jun 29;12(3):e0079921
pubmed: 34061592
Cell Stem Cell. 2023 Mar 2;30(3):312-332.e13
pubmed: 36796362