Lupus anticoagulant-hypoprothrombinemia syndrome: A cerebral bleeding case report as systemic lupus erythematosus debut.
Adult
Adulto
Hipoprotrombinemia
Hypoprothrombinaemia
Inhibidor de la coagulación lúpica
Lupus anticoagulant-hypoprothrombinaemia syndrome
Lupus coagulation inhibitor
Lupus eritematoso sistémico
Systemic lupus erythematosus
Síndrome de anticoagulante lúpico-hipoprotrombinemia
Journal
Reumatologia clinica
ISSN: 2173-5743
Titre abrégé: Reumatol Clin (Engl Ed)
Pays: Spain
ID NLM: 101717526
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
15
11
2021
accepted:
23
02
2022
medline:
18
4
2023
entrez:
15
4
2023
pubmed:
16
4
2023
Statut:
ppublish
Résumé
Lupus anticoagulant-hypoprothrombinaemia syndrome (LAHPS) is a rare disorder caused by the presence of lupus anticoagulant (LA) and acquired prothrombin deficiency, which may present with severe haemorrhagic manifestations. LAHPS is usually associated with systemic lupus erythematosus (SLE), or infections and it is more frequent in the paediatric population and female gender. We describe a 42-year-old man with thrombotic antiphospholipid syndrome (APS) on chronic anticoagulation treatment with acenocoumarol who presented with spontaneous intracranial bleeding, prolongation of prothrombin time (PT), activated partial thromboplastin time (APTT) and low factor II levels (after optimal anticoagulation reversal) as a debut of SLE.
Identifiants
pubmed: 37061283
pii: S2173-5743(23)00036-9
doi: 10.1016/j.reumae.2022.02.008
pii:
doi:
Substances chimiques
Lupus Coagulation Inhibitor
0
Prothrombin
9001-26-7
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
223-227Informations de copyright
Copyright © 2022 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.