Hippocampal inactivation during rearing on hind legs impairs spatial memory.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 04 2023
15 04 2023
Historique:
received:
24
10
2022
accepted:
09
04
2023
medline:
18
4
2023
entrez:
15
4
2023
pubmed:
16
4
2023
Statut:
epublish
Résumé
Spatial memory requires an intact hippocampus. Hippocampal function during epochs of locomotion and quiet rest (e.g., grooming and reward consumption) has been the target of extensive study. However, during navigation rats frequently rear up onto their hind legs, and the importance of hippocampal activity during these periods of attentive sampling for spatial memory is unknown. To address this, we tested the necessity of dorsal hippocampal activity during rearing epochs in the study phase of a delayed win-shift task for memory performance in the subsequent test phase. Hippocampal activity was manipulated with closed-loop, bilateral, optogenetic inactivation. Spatial memory accuracy was significantly and selectively reduced when the dorsal hippocampus was inactivated during rearing epochs at encoding. These data show that hippocampal activity during periods of rearing can be important for spatial memory, revealing a novel link between hippocampal function during epochs of rearing and spatial memory.
Identifiants
pubmed: 37061540
doi: 10.1038/s41598-023-33209-9
pii: 10.1038/s41598-023-33209-9
pmc: PMC10105745
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6136Subventions
Organisme : NIA NIH HHS
ID : R01 AG076198
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
Behav Brain Res. 2003 Jul 14;143(1):31-40
pubmed: 12842293
Behav Processes. 2004 Sep 30;67(2):173-81
pubmed: 15240055
Nature. 2006 Mar 30;440(7084):680-3
pubmed: 16474382
Anim Behav. 1968 Feb;16(1):92-6
pubmed: 5639909
Acta Med Okayama. 2016 Dec;70(6):455-460
pubmed: 28003670
Nat Neurosci. 2015 Feb;18(2):282-8
pubmed: 25531571
Neuroscience. 2016 Nov 19;337:224-241
pubmed: 27615031
Neural Comput. 2002 Apr;14(4):793-817
pubmed: 11936962
Elife. 2014 Jul 29;3:e03061
pubmed: 25073927
Science. 1972 Jan 7;175(4017):87-9
pubmed: 5008585
Physiol Behav. 1996 Nov;60(5):1255-60
pubmed: 8916179
Exp Neurol. 1978 Sep 15;61(3):485-515
pubmed: 710563
Brain Res. 1990 Sep 24;528(1):12-20
pubmed: 2245328
Behav Brain Res. 2001 Nov 1;125(1-2):127-32
pubmed: 11682103
Neuropsychologia. 1979;17(6):669-82
pubmed: 522981
Behav Brain Res. 1983 Feb;7(2):133-53
pubmed: 6830648
Behav Neurosci. 1994 Jun;108(3):456-68
pubmed: 7917039
Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14515-20
pubmed: 15452348
Netw Neurosci. 2017 Dec 01;1(4):339-356
pubmed: 30090870
Cell. 2010 Apr 2;141(1):154-165
pubmed: 20303157
Nature. 1982 Jun 24;297(5868):681-3
pubmed: 7088155
Science. 1978 Jul 14;201(4351):160-3
pubmed: 663646
Dev Psychobiol. 1975 Jan;8(1):35-9
pubmed: 1233318
Psychopharmacology (Berl). 1992;108(3):352-62
pubmed: 1523285
Learn Mem. 2009 Dec 22;17(1):5-11
pubmed: 20028732
Hippocampus. 2013 Dec;23(12):1269-79
pubmed: 23832676
J Comp Physiol Psychol. 1978 Dec;92(6):1119-27
pubmed: 755058
Hippocampus. 2006;16(9):755-64
pubmed: 16883558
Brain Res. 1978 Jan 13;139(2):295-308
pubmed: 624061
Nat Neurosci. 2014 May;17(5):725-31
pubmed: 24686786
Behav Brain Res. 2002 May 14;132(2):203-13
pubmed: 11997150
Nat Neurosci. 2010 Aug;13(8):995-1002
pubmed: 20639874
Hippocampus. 2006;16(9):730-42
pubmed: 16921500
Brain Res. 1971 Nov;34(1):171-5
pubmed: 5124915
Stress. 2018 Sep;21(5):443-452
pubmed: 29451062
Hippocampus. 2008;18(10):1064-73
pubmed: 18651615
Neuroimage. 2015 Feb 15;107:229-241
pubmed: 25462689
Anesthesiology. 2004 Feb;100(2):309-14
pubmed: 14739805
Rev Neurosci. 2006;17(1-2):111-33
pubmed: 16703946
J Neurosci. 2013 May 15;33(20):8650-67
pubmed: 23678110
J Neurosci. 2013 May 15;33(20):8689-704
pubmed: 23678113
Science. 1978 Jun 16;200(4347):1298-300
pubmed: 663612
Methods Find Exp Clin Pharmacol. 1997 May;19(4):253-9
pubmed: 9228651
Neuroscience. 1998 Aug;85(4):1253-62
pubmed: 9681961
Neuropharmacology. 2004 Apr;46(5):672-87
pubmed: 14996545
Science. 2012 Jun 15;336(6087):1454-8
pubmed: 22555434
Cell Rep. 2018 May 8;23(6):1706-1715
pubmed: 29742427
Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7054-9
pubmed: 20351262
Behav Brain Res. 2015 May 15;285:105-17
pubmed: 25169255
Neuron. 2009 Sep 10;63(5):643-56
pubmed: 19755107
Neuron. 1999 Jun;23(2):209-26
pubmed: 10399928
Brain Res. 1994 May 2;644(2):352-6
pubmed: 8050049
J Neurosci. 2013 Apr 3;33(14):6212-24
pubmed: 23554502
Cell Mol Biol (Noisy-le-grand). 2003 Dec;49(8):1275-80
pubmed: 14983998
Nat Neurosci. 2007 Oct;10(10):1241-2
pubmed: 17828259
Brain Res. 1990 Jul 30;524(1):72-6
pubmed: 2400933
J Neurosci. 1982 Mar;2(3):292-302
pubmed: 7062110
Sci Rep. 2015 Dec 07;5:17697
pubmed: 26639399
Proc Biol Sci. 2022 May 11;289(1974):20220237
pubmed: 35538783
Anesth Analg. 2003 Apr;96(4):1004-1009
pubmed: 12651650
Hippocampus. 2006;16(12):1102-10
pubmed: 17068783
J Comp Physiol Psychol. 1982 Aug;96(4):563-73
pubmed: 7119176
Psychol Rev. 2007 Oct;114(4):887-953
pubmed: 17907868
Cereb Cortex. 2009 Jan;19(1):24-40
pubmed: 18453538
Hippocampus. 2014 Jun;24(6):693-702
pubmed: 24520011
Behav Brain Res. 2009 Jan 30;197(1):234-8
pubmed: 18789358
J Neurosci. 2009 Feb 4;29(5):1381-94
pubmed: 19193885