Boron uptake of boronophenylalanine and the effect of boron neutron capture therapy in cervical cancer cells.
Boron concentration
Cervical cancer
Neutron capture therapy
Journal
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
ISSN: 1872-9800
Titre abrégé: Appl Radiat Isot
Pays: England
ID NLM: 9306253
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
19
10
2021
revised:
13
06
2022
accepted:
26
03
2023
medline:
15
5
2023
pubmed:
17
4
2023
entrez:
16
4
2023
Statut:
ppublish
Résumé
There are few studies about boron neutron capture therapy (BNCT) for cervical cancer. The present study evaluated the biodistribution of boronophenylalanine (BPA) and the effect of BNCT on cervical cancer cell lines. BPA exposure and neutron irradiation of cervical cancer cell lines resulted in decreased survival fraction compared to irradiation only. In vivo cervical cancer tumor boron concentration was highest at 2.5 h after BPA intraperitoneal administration, and higher than in the other organs. BNCT may be effective against cervical carcinoma.
Identifiants
pubmed: 37062147
pii: S0969-8043(23)00145-8
doi: 10.1016/j.apradiso.2023.110792
pii:
doi:
Substances chimiques
Boron
N9E3X5056Q
Boron Compounds
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110792Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.