Intravenous Immunoglobulin: Mechanism of Action in Autoimmune and Inflammatory Conditions.
Adaptive immunity
Autoimmunity
IVIG
Inflammation
Innate immunity
Intravenous immunoglobulin
Tregs
Journal
The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
07
12
2022
revised:
04
04
2023
accepted:
11
04
2023
medline:
12
6
2023
pubmed:
17
4
2023
entrez:
16
4
2023
Statut:
ppublish
Résumé
Intravenous immunoglobulin (IVIG) is the mainstay of therapy for humoral immune deficiencies and numerous inflammatory disorders. Although the use of IVIG may be supplanted by several targeted therapies to cytokines, the ability of polyclonal normal IgG to act as an effector molecule as well as a regulatory molecule is a clear example of the polyfunctionality of IVIG. This article will address the mechanism of action of IVIG in a number of important conditions that are otherwise resistant to treatment. In this commentary, we will highlight mechanistic studies that shed light on the action of IVIG. This will be approached by identifying effects that are both common and disease-specific, targeting actions that have been demonstrated on cells and processes that represent both innate and adaptive immune responses.
Identifiants
pubmed: 37062358
pii: S2213-2198(23)00402-6
doi: 10.1016/j.jaip.2023.04.002
pii:
doi:
Substances chimiques
Immunoglobulins, Intravenous
0
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1688-1697Informations de copyright
Copyright © 2023 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.