The angiogenic gene profile of pulmonary endarterectomy specimens: Initial study.
angiogenesis
chronic thromboembolic pulmonary hypertension
gene expression
Journal
JTCVS open
ISSN: 2666-2736
Titre abrégé: JTCVS Open
Pays: Netherlands
ID NLM: 101768541
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
24
08
2022
revised:
03
12
2022
accepted:
19
12
2022
medline:
18
4
2023
entrez:
17
4
2023
pubmed:
18
4
2023
Statut:
epublish
Résumé
The underlying mechanisms for the development of chronic thromboembolic pulmonary hypertension and prognostic biomarkers are not clear yet. Thus, our aim is to assess and identify new biomarkers for the expression of 84 key genes linked to angiogenesis. Patients who had levels more than 1000 dynes·sec·cm Eight patients (6 male, 2 female, median age 54.4 ± 13.1 years) who underwent pulmonary endarterectomy were included. Pulmonary vascular resistance improved significantly from 811 ± 390 dyn/s/cm These results can lead to the development of new markers that could predict adverse outcomes of patients with CTEPH. Identification of new markers that are related to worse outcomes would enable screening patients for early diagnosis and treatment.
Identifiants
pubmed: 37063122
doi: 10.1016/j.xjon.2022.12.010
pii: S2666-2736(23)00003-7
pmc: PMC10091285
doi:
Types de publication
Journal Article
Langues
eng
Pagination
423-434Informations de copyright
© 2023 The Author(s).
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