Associations between vitamin D, immunoglobulin E concentrations, and obesity.
25(OH)D
BMI
IgE
SAT
VAT
adipose tissue
obesity
vitamin D
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
01
2023
accepted:
14
03
2023
medline:
18
4
2023
entrez:
17
4
2023
pubmed:
18
4
2023
Statut:
epublish
Résumé
The prevalence of allergies and obesity has been increased in parallel. Low vitamin D [25(OH)D] levels have been linked to both higher body mass index (BMI) and allergies. Since the activation of the 25(OH)D receptor inhibits IgE production and 25(OH)D influences the IgE response specifically, we tested the hypothesis that circulating 25(OH)D concentrations are negatively related to circulating allergen-specific IgE concentrations distinctly in a large adult population-based study cohort. Moreover, we studied VDR gene expression in paired biopsies of abdominal subcutaneous (SAT) and visceral adipose tissue (VAT). We investigated whether magnetic resonance imaging-estimated visceral (VFM) and subcutaneous fat mass (SFM) are related to 25(OH)D levels. We found gender differences in circulating 25(OH)D and IgE concentrations. Participants with obesity showed lower 25(OH)D concentrations and higher IgE concentrations were detected in women only. Interestingly, participants with high levels of 25(OH)D are leaner and have improved glucose metabolism. In women, 25(OH)D correlate significant with VFM and SFM.
Identifiants
pubmed: 37063318
doi: 10.3389/fnut.2023.1147407
pmc: PMC10097930
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1147407Informations de copyright
Copyright © 2023 Avila Castillo, Hagemann, Hoffmann, Baber, Biemann, Wirkner, Krupka, Stumvoll, Blüher and Klöting.
Déclaration de conflit d'intérêts
MB received honoraria as a consultant and speaker from Amgen, AstraZeneca, Bayer, Boehringer-Ingelheim, Lilly, Novo Nordisk, Novartis, and Sanofi. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Asthma. 2020 Oct;57(10):1053-1062
pubmed: 31204534
Obesity (Silver Spring). 2013 Mar;21(3):529-34
pubmed: 23592659
J Immunol. 2017 Feb 1;198(3):1164-1171
pubmed: 28003380
Int J Epidemiol. 2023 Feb 8;52(1):e66-e79
pubmed: 35640047
Expert Rev Respir Med. 2015 Jun;9(3):309-25
pubmed: 25947112
Am J Clin Nutr. 2010 Nov;92(5):1017-22
pubmed: 20810979
Curr Opin Allergy Clin Immunol. 2016 Apr;16(2):113-9
pubmed: 26844753
Nat Rev Endocrinol. 2019 May;15(5):288-298
pubmed: 30814686
Curr Opin Allergy Clin Immunol. 2019 Feb;19(1):7-11
pubmed: 30507714
Immunology. 2011 Oct;134(2):123-39
pubmed: 21896008
Int J Clin Exp Med. 2015 Sep 15;8(9):14977-84
pubmed: 26628980
Lancet Respir Med. 2020 Jun;8(6):585-596
pubmed: 32526187
Inflamm Bowel Dis. 2020 Nov 19;26(12):1819-1830
pubmed: 32385487
Obes Facts. 2018;11(6):475-490
pubmed: 30537708
Allergy. 2011 Apr;66(4):540-8
pubmed: 21121929
Eur J Clin Nutr. 2020 Nov;74(11):1498-1513
pubmed: 31959942
Clin Exp Allergy. 1994 Jun;24(6):530-9
pubmed: 7922774
J Clin Endocrinol Metab. 2019 Jan 1;104(1):49-56
pubmed: 30137362
Diabetes Metab Syndr Obes. 2014 Dec 04;7:587-91
pubmed: 25506234
Neurol Neuroimmunol Neuroinflamm. 2020 Jan 14;7(2):
pubmed: 31937597
Mol Metab. 2020 Dec;42:101095
pubmed: 33045433
Ann Allergy Asthma Immunol. 2010 Sep;105(3):191-9; quiz 200-2, 217
pubmed: 20800785
Curr Atheroscler Rep. 2002 Nov;4(6):448-53
pubmed: 12361492
J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):93-101
pubmed: 16046118
Lancet. 2020 Sep 19;396(10254):854-866
pubmed: 32910907
BMC Public Health. 2015 Jul 22;15:691
pubmed: 26197779
Exp Ther Med. 2016 Oct;12(4):2395-2399
pubmed: 27703502
Obesity (Silver Spring). 2013 Dec;21(12):E599-606
pubmed: 23526677
Am J Epidemiol. 2012 May 15;175(10):1029-36
pubmed: 22312120
Pediatr Pulmonol. 2021 Feb;56(2):354-361
pubmed: 32930511
Obes Rev. 2015 Apr;16(4):341-9
pubmed: 25688659
J Am Coll Nutr. 2009 Jun;28(3):252-6
pubmed: 20150598
Br J Nutr. 2012 Dec 14;108(11):1915-23
pubmed: 23046765
Aliment Pharmacol Ther. 2019 Dec;50(11-12):1146-1158
pubmed: 31647134
Front Endocrinol (Lausanne). 2018 May 31;9:246
pubmed: 29904370
Allergy. 2007 Oct;62(10):1205-13
pubmed: 17845592
J Clin Endocrinol Metab. 2015 Apr;100(4):E591-5
pubmed: 25706239
Afr Health Sci. 2020 Jun;20(2):897-902
pubmed: 33163057
Int Arch Allergy Immunol. 2021;182(3):220-228
pubmed: 33176332
Climacteric. 2020 Aug;23(4):410-416
pubmed: 32367772
JAMA. 2020 Aug 25;324(8):752-760
pubmed: 32840597
Int Immunol. 2018 Aug 30;30(9):403-412
pubmed: 30053010
Clin Exp Allergy. 2015 Jan;45(1):114-25
pubmed: 25307157
J Steroid Biochem Mol Biol. 2008 Nov;112(1-3):122-6
pubmed: 18840526
J Allergy Clin Immunol. 2011 May;127(5):1195-202
pubmed: 21329969
Endocrinology. 2009 Feb;150(2):651-61
pubmed: 18845643
Metabolism. 2019 Mar;92:193-205
pubmed: 30615949
J Clin Invest. 1971 Mar;50(3):679-87
pubmed: 4322721
J Leukoc Biol. 2020 Mar;107(3):409-418
pubmed: 31965637
Int J Obes (Lond). 2021 Feb;45(2):331-336
pubmed: 32873909
Biochem Biophys Res Commun. 1993 Jun 30;193(3):948-55
pubmed: 7686756
Curr Med Chem. 2017;24(24):2671-2686
pubmed: 28000549
Respir Med. 2009 Feb;103(2):289-95
pubmed: 18818065
Ann Nutr Metab. 2012;60(4):241-6
pubmed: 22677925