Dodecyl creatine ester improves cognitive function and identifies key protein drivers including KIF1A and PLCB1 in a mouse model of creatine transporter deficiency.

CTD-pathophysiology cognitive function creatine transporter deficiency dodecyl creatine ester target identification

Journal

Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914

Informations de publication

Date de publication:
2023
Historique:
received: 07 12 2022
accepted: 20 02 2023
medline: 18 4 2023
entrez: 17 4 2023
pubmed: 18 4 2023
Statut: epublish

Résumé

Creatine transporter deficiency (CTD), a leading cause of intellectual disability is a result of the mutation in the gene encoding the creatine transporter SLC6A8, which prevents creatine uptake into the brain, causing mental retardation, expressive speech and language delay, autistic-like behavior and epilepsy. Preclinical

Identifiants

pubmed: 37063368
doi: 10.3389/fnmol.2023.1118707
pmc: PMC10103630
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1118707

Informations de copyright

Copyright © 2023 Mabondzo, Harati, Broca-Brisson, Guyot, Costa, Cacciante, Putignano, Baroncelli, Skelton, Saab, Martini, Benech, Joudinaud, Gaillard, Armengaud and Hamoudi.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Aloïse Mabondzo (A)

Université Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), Gif sur Yvette, France.

Rania Harati (R)

Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharja, Sharjah, United Arab Emirates.
Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.

Léa Broca-Brisson (L)

Université Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), Gif sur Yvette, France.

Anne-Cécile Guyot (AC)

Université Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), Gif sur Yvette, France.

Narciso Costa (N)

Université Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), Gif sur Yvette, France.

Francesco Cacciante (F)

Institute of Neuroscience, National Research Council (CNR), Pisa, Italy.

Elena Putignano (E)

Institute of Neuroscience, National Research Council (CNR), Pisa, Italy.

Laura Baroncelli (L)

Institute of Neuroscience, National Research Council (CNR), Pisa, Italy.
Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Pisa, Italy.

Matthew R Skelton (MR)

Department of Pediatrics, University of Cincinnati College of Medicine and Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, United States.

Cathy Saab (C)

Université de Paris and Université Paris Saclay, CEA, Stabilité Génétique Cellules Souches et Radiations, Fontenay aux Roses, France.

Emmanuelle Martini (E)

Université de Paris and Université Paris Saclay, CEA, Stabilité Génétique Cellules Souches et Radiations, Fontenay aux Roses, France.

Henri Benech (H)

Ceres Brain Therapeutics, Paris, France.

Thomas Joudinaud (T)

Ceres Brain Therapeutics, Paris, France.

Jean-Charles Gaillard (JC)

Université Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé (MTS), INRAE, Bagnol sur Cèze, France.

Jean Armengaud (J)

Université Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé (MTS), INRAE, Bagnol sur Cèze, France.

Rifat Hamoudi (R)

Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Clinical Sciences Department, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Division of Surgery and Interventional Science, University College London, London, United Kingdom.

Classifications MeSH