Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicity.
HCV
NASH
PSC
ScRNA-seq
cirrhosis
innate lymphocyte cells
liver
natural killer cells
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
03
01
2023
accepted:
15
03
2023
medline:
18
4
2023
entrez:
17
4
2023
pubmed:
18
4
2023
Statut:
epublish
Résumé
The natural killer (NK) cell population is a critical component of the innate immune compartment of the liver, and its functions are deeply affected by the surrounding environment. In the late stage of fibrosis, NK cells become dysfunctional, but the influence of disease etiology on NK cell behavior during cirrhosis remains unclear. Using single-cell RNA sequencing (scRNA-seq), we characterized the hepatic NK cells from end-stage cirrhotic livers from subjects with non-alcoholic steatohepatitis (NASH), chronic hepatitis C infection (HCV) and primary sclerosing cholangitis (PSC). Here, we show that although NK cells shared similar dysfunctions, the disease etiology impacts hepatic NK cell heterogeneity. Therapeutical strategies targeting NK cells for the prevention or treatment of fibrosis should consider liver disease etiology in their design.
Identifiants
pubmed: 37063898
doi: 10.3389/fimmu.2023.1137034
pmc: PMC10098346
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1137034Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK048522
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK106491
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117004
Pays : United States
Informations de copyright
Copyright © 2023 Maretti-Mira, Salomon, Hsu, Dara and Golden-Mason.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Gastroenterology. 2010 Jan;138(1):325-35.e1-2
pubmed: 19747917
Acta Neuropathol. 2013 Nov;126(5):699-709
pubmed: 23995423
Front Immunol. 2015 Jul 27;6:368
pubmed: 26284063
Bioinformatics. 2014 Feb 15;30(4):523-30
pubmed: 24336805
Hum Immunol. 1999 Jan;60(1):20-31
pubmed: 9952024
Front Med. 2018 Jun;12(3):269-279
pubmed: 29675689
Front Immunol. 2012 Feb 10;3:14
pubmed: 22566900
Oncogene. 2017 Apr;36(15):2095-2104
pubmed: 27721403
Front Immunol. 2022 Sep 08;13:968366
pubmed: 36159810
Science. 2017 Jan 27;355(6323):395-398
pubmed: 28126818
J Immunol Methods. 2000 Aug 28;242(1-2):21-31
pubmed: 10986386
J Immunol. 2016 Dec 1;197(11):4283-4291
pubmed: 27798170
iScience. 2020 Aug 29;23(9):101513
pubmed: 32920488
Semin Immunopathol. 2021 Aug;43(4):519-533
pubmed: 34230995
Gut. 2020 Oct;69(10):1855-1866
pubmed: 32001554
Nature. 2018 Aug;560(7719):494-498
pubmed: 30089906
Nat Immunol. 2018 Dec;19(12):1330-1340
pubmed: 30420624
Hepatology. 2013 Apr;57(4):1654-62
pubmed: 23111952
J Gastroenterol. 2007 Jul;42(7):513-21
pubmed: 17653645
Gastroenterology. 2006 Feb;130(2):435-52
pubmed: 16472598
Nat Biotechnol. 2020 Dec;38(12):1408-1414
pubmed: 32747759
Gastroenterology. 2001 May;120(6):1475-82
pubmed: 11313318
J Hepatol. 2007 May;46(5):899-906
pubmed: 17383044
Nat Rev Immunol. 2013 Feb;13(2):145-9
pubmed: 23348417
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10895-900
pubmed: 18667695
PLoS One. 2014 Apr 23;9(4):e95614
pubmed: 24759660
Hepatology. 2016 Jul;64(1):73-84
pubmed: 26707365
Front Immunol. 2019 Jun 07;10:1309
pubmed: 31231399
Gigascience. 2018 Jul 1;7(7):
pubmed: 30010766
Hepatology. 2012 Sep;56(3):841-9
pubmed: 22431186
Nat Rev Gastroenterol Hepatol. 2013 Nov;10(11):627-36
pubmed: 23958599
Biochim Biophys Acta. 2013 Jul;1832(7):1061-9
pubmed: 23022478
Genome Biol. 2018 Feb 6;19(1):15
pubmed: 29409532
J Hepatol. 2019 Oct;71(4):773-782
pubmed: 31173810
Hepatology. 2008 Feb;47(2):729-36
pubmed: 18167066
Nucleic Acids Res. 2019 Jul 2;47(W1):W191-W198
pubmed: 31066453
Genome Biol. 2019 Dec 23;20(1):296
pubmed: 31870423
Front Immunol. 2017 Mar 21;8:317
pubmed: 28377769
Cold Spring Harb Perspect Biol. 2012 Mar 01;4(3):
pubmed: 22383753
Cell. 2021 Jun 24;184(13):3573-3587.e29
pubmed: 34062119
Front Immunol. 2021 Feb 25;12:622306
pubmed: 33717125
J Clin Invest. 2009 Jul;119(7):1858-70
pubmed: 19603542
Cancer Res. 2013 Aug 1;73(15):4653-62
pubmed: 23761327
Mol Med Rep. 2022 Jun;25(6):
pubmed: 35506449
J Hepatol. 2020 Mar;72(3):558-577
pubmed: 31622696
J Hepatol. 1998 Jan;28(1):84-90
pubmed: 9537869
Nat Immunol. 2002 Jun;3(6):536-41
pubmed: 12021777
Nat Biotechnol. 2018 Jun;36(5):411-420
pubmed: 29608179
Bioinformatics. 2021 Aug 25;37(16):2485-2487
pubmed: 33459785
Immunity. 2016 May 17;44(5):1005-19
pubmed: 27192566
Nat Immunol. 2001 Dec;2(12):1126-32
pubmed: 11702067
J Hepatol. 2008;48 Suppl 1:S38-57
pubmed: 18304683
J Hepatol. 2014 Dec;61(6):1385-96
pubmed: 25135860
J Immunol Res. 2018 Sep 4;2018:1206737
pubmed: 30255103
Best Pract Res Clin Gastroenterol. 2011 Apr;25(2):195-206
pubmed: 21497738
Immunity. 2005 Jan;22(1):131-42
pubmed: 15664165
J Immunol. 2015 Feb 15;194(4):1832-40
pubmed: 25595786
Front Immunol. 2021 Feb 18;12:640869
pubmed: 33679803
J Immunol. 2013 Apr 15;190(8):4349-59
pubmed: 23509368
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
Immunology. 2009 Sep;128(1 Suppl):e514-22
pubmed: 19740312
Allergy. 2008 Jun;63(6):703-11
pubmed: 18070228
Cold Spring Harb Perspect Med. 2020 Sep 1;10(9):
pubmed: 31871225
Sci Signal. 2016 Feb 16;9(415):ra19
pubmed: 26884601
Gut. 2012 Jun;61(6):885-93
pubmed: 22198715
Liver Res. 2017 Dec;1(4):221-230
pubmed: 29977644
Nature. 2015 Jan 15;517(7534):293-301
pubmed: 25592534
Front Immunol. 2019 Aug 21;10:1999
pubmed: 31552017
Front Physiol. 2012 Jun 20;3:213
pubmed: 22723782