Magnetic resonance imaging reference values for cardiac morphology, function and tissue composition in adolescents.
Adolescent
Differential diagnosis
Magnetic resonance
Pediatrics
Reference values
Ventricular function
Journal
EClinicalMedicine
ISSN: 2589-5370
Titre abrégé: EClinicalMedicine
Pays: England
ID NLM: 101733727
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
14
10
2022
revised:
09
02
2023
accepted:
10
02
2023
medline:
18
4
2023
entrez:
17
4
2023
pubmed:
18
4
2023
Statut:
epublish
Résumé
Cardiovascular magnetic resonance (CMR) is a precise tool for the assessment of cardiac anatomy, function, and tissue composition. However, studies providing CMR reference values in adolescence are scarce. We aim to provide sex-specific CMR reference values for biventricular and atrial dimensions and function and myocardial relaxation times in this population. Adolescents aged 15-18 years with no known cardiovascular disease underwent a non-contrast 3-T CMR scan between March 2021 and October 2021. The imaging protocol included a cine steady-state free-precession sequence for the analysis of chamber size and function, as well as T2-GraSE and native MOLLI T1-mapping for the characterization of myocardial tissue. CMR scans were performed in 123 adolescents (mean age 16 ± 0.5 years, 52% girls). Mean left and right ventricular end-diastolic indexed volumes were higher in boys than in girls (91.7 ± 11.6 vs 78.1 ± 8.3 ml/m This cross-sectional study provides overall and sex-stratified CMR reference values for cardiac dimensions and function, and myocardial tissue properties, in adolescents. This information is useful for clinical practice and may help in the differential diagnosis of cardiac diseases, such as cardiomyopathies and myocarditis, in this population. Instituto de Salud Carlos III (PI19/01704).
Sections du résumé
Background
UNASSIGNED
Cardiovascular magnetic resonance (CMR) is a precise tool for the assessment of cardiac anatomy, function, and tissue composition. However, studies providing CMR reference values in adolescence are scarce. We aim to provide sex-specific CMR reference values for biventricular and atrial dimensions and function and myocardial relaxation times in this population.
Methods
UNASSIGNED
Adolescents aged 15-18 years with no known cardiovascular disease underwent a non-contrast 3-T CMR scan between March 2021 and October 2021. The imaging protocol included a cine steady-state free-precession sequence for the analysis of chamber size and function, as well as T2-GraSE and native MOLLI T1-mapping for the characterization of myocardial tissue.
Findings
UNASSIGNED
CMR scans were performed in 123 adolescents (mean age 16 ± 0.5 years, 52% girls). Mean left and right ventricular end-diastolic indexed volumes were higher in boys than in girls (91.7 ± 11.6 vs 78.1 ± 8.3 ml/m
Interpretation
UNASSIGNED
This cross-sectional study provides overall and sex-stratified CMR reference values for cardiac dimensions and function, and myocardial tissue properties, in adolescents. This information is useful for clinical practice and may help in the differential diagnosis of cardiac diseases, such as cardiomyopathies and myocarditis, in this population.
Funding
UNASSIGNED
Instituto de Salud Carlos III (PI19/01704).
Identifiants
pubmed: 37064511
doi: 10.1016/j.eclinm.2023.101885
pii: S2589-5370(23)00062-7
pmc: PMC10102894
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101885Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
Javier Sánchez-González is a Philips Healthcare employee. Carlos Real is funded by the Fundacion Interhospitalaria para la Investigación Cardiovascular. The remaining authors declare no conflicts of interest.
Références
J Cardiovasc Magn Reson. 2017 Oct 9;19(1):75
pubmed: 28992817
J Cardiovasc Magn Reson. 2020 Mar 12;22(1):19
pubmed: 32160925
Eur J Prev Cardiol. 2022 Feb 19;29(1):e7-e10
pubmed: 33624055
J Am Soc Echocardiogr. 2019 Aug;32(8):1036-1045.e9
pubmed: 31147145
J Magn Reson Imaging. 2017 Apr;45(4):1055-1067
pubmed: 27571232
Vital Health Stat 3. 2021 Jan;(36):1-44
pubmed: 33541517
Invest Radiol. 2021 Nov 1;56(11):692-704
pubmed: 34417406
J Magn Reson Imaging. 2009 Mar;29(3):552-9
pubmed: 19243036
J Cardiovasc Magn Reson. 2014 Jan 04;16:2
pubmed: 24387626
Eur Heart J Cardiovasc Imaging. 2021 Dec 18;23(1):14-30
pubmed: 34718484
Radiology. 2019 Feb;290(2):317-326
pubmed: 30422092
Circulation. 2002 Jan 29;105(4):539-42
pubmed: 11815441
Int J Cardiovasc Imaging. 2020 Jan;36(1):101-110
pubmed: 31401742
J Cardiovasc Magn Reson. 2013 Jan 20;15:13
pubmed: 23331520
J Magn Reson Imaging. 2016 Nov;44(5):1186-1196
pubmed: 27143317
Circ Cardiovasc Imaging. 2010 Jan;3(1):65-76
pubmed: 19820203
Eur Heart J Cardiovasc Imaging. 2020 Jan 1;21(1):102-113
pubmed: 31280290
Eur Radiol. 2021 May;31(5):2788-2797
pubmed: 33128187
Int J Cardiol. 2022 Apr 1;352:180-187
pubmed: 35124105
J Cardiovasc Magn Reson. 2022 Jul 21;24(1):44
pubmed: 35864534
Am Heart J. 2019 Sep;215:27-40
pubmed: 31277052
J Cardiovasc Magn Reson. 2020 Dec 14;22(1):87
pubmed: 33308262
J Magn Reson Imaging. 2015 Apr;41(4):1038-45
pubmed: 24817313
Lancet. 2007 Oct 20;370(9596):1453-7
pubmed: 18064739
J Cardiovasc Magn Reson. 2009 Jun 21;11:19
pubmed: 19545393
J Am Coll Cardiol. 2014 Feb 18;63(6):493-505
pubmed: 24291276
J Am Coll Cardiol. 2018 Dec 18;72(24):3158-3176
pubmed: 30545455
J Cardiovasc Magn Reson. 2017 Sep 21;19(1):72
pubmed: 28934962
J Cardiovasc Magn Reson. 2015 Nov 04;17:92
pubmed: 26538198
Front Cardiovasc Med. 2017 Feb 15;4:5
pubmed: 28261582
J Cardiovasc Magn Reson. 2016 Oct 10;18(1):64
pubmed: 27719670
J Magn Reson Imaging. 2011 May;33(5):1028-39
pubmed: 21509858
J Cardiovasc Magn Reson. 2017 Feb 3;19(1):18
pubmed: 28178995
Pediatr Cardiol. 2020 Apr;41(4):654-668
pubmed: 32342149
Eur Heart J Cardiovasc Imaging. 2016 Sep;17(9):981-90
pubmed: 26354980