Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.
ESCRT
Huntington
NCT-504
Neurodegeneration
Tau
huntingtin
multivesicular bodies (MVB)
Journal
Autophagy reports
ISSN: 2769-4127
Titre abrégé: Autophagy Rep
Pays: United States
ID NLM: 9918383885906676
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
18
4
2023
entrez:
17
4
2023
pubmed:
18
4
2023
Statut:
ppublish
Résumé
Many neurodegenerative diseases, including Huntington's disease (HD) and Alzheimer's disease (AD), occur due to an accumulation of aggregation-prone proteins, which results in neuronal death. Studies in animal and cell models show that reducing the levels of these proteins mitigates disease phenotypes. We previously reported a small molecule, NCT-504, which reduces cellular levels of mutant huntingtin (mHTT) in patient fibroblasts as well as mouse striatal and cortical neurons from an Hdh
Identifiants
pubmed: 37064812
doi: 10.1080/27694127.2023.2166722
pmc: PMC10101321
mid: NIHMS1884781
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS099340
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS122302
Pays : United States
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