Throat Swab Culture Positivity and Antibiotic Resistance Profiles in Children 2-5 Years of Age Suspected of Bacterial Tonsillitis at Hargeisa Group of Hospitals, Somaliland: A Cross-Sectional Study.
Journal
International journal of microbiology
ISSN: 1687-918X
Titre abrégé: Int J Microbiol
Pays: Egypt
ID NLM: 101516125
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
04
2022
revised:
11
12
2022
accepted:
17
03
2023
medline:
18
4
2023
entrez:
17
4
2023
pubmed:
18
4
2023
Statut:
epublish
Résumé
Tonsillitis is the third most frequently diagnosed infection in the pediatric age and is associated with significant morbidity and loss of school attendance. Throat swab cultures are useful for the confirmation of children with a clinically suspected tonsillitis. However, Somaliland is one of the underdeveloped countries with a low standard of sanitation and poor health seeking culture. Treatment of tonsillitis with antibiotics is irrational and not empirical. This study determined the bacterial throat swab culture positivity and antibiotic resistance profiles of the bacterial isolates among children 2-5 years of age with suspicion of tonsillitis at Hargeisa Group of Hospital, Somaliland. A cross-sectional study was conducted from March to July 2020. A total of 374 children from 2 to 5 years of age suspicion of tonsillitis was included using a convenient sampling method. Throat swabs were collected, and bacterial isolation and identification were done using standard bacteriological procedures. Antimicrobial susceptibility testing was done using the disk diffusion method. Data on demographic variables and clinical profiles were collected using structured questionnaires. Logistic regression analysis was computed to identify factors associated with bacterial tonsillitis. Overall, 120 (32.1%) (95% CI 27.4-36.8%) of children were positive for bacterial throat cultures. Of these, 23 (19.2%) were mixed bacterial isolates. The most frequent bacterial isolates were beta-hemolytic streptococci 78 (55%), Resistance to ampicillin and MDR among beta-hemolytic streptococci and other isolates of throat colonizers in children with clinically suspected of bacterial tonsillitis are major concerns in Hargeisa, Somaliland. Therefore, treatments of cases are recommended to be guided by regular culture and antimicrobial susceptibility testing to prevent complications of tonsillitis and associated antibiotic resistance.
Identifiants
pubmed: 37065723
doi: 10.1155/2023/6474952
pmc: PMC10098414
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6474952Informations de copyright
Copyright © 2023 Hamda Hussein Darod et al.
Déclaration de conflit d'intérêts
The authors declare that there were no conflicts of interest regarding the publication of this article.
Références
Acta Otorhinolaryngol Ital. 2009 Oct;29(5):255-8
pubmed: 20162026
Diagn Microbiol Infect Dis. 2005 Apr;51(4):271-80
pubmed: 15808319
Trop Med Int Health. 2014 Apr;19(4):431-9
pubmed: 24405659
Adv Prev Med. 2018 Dec 11;2018:9364757
pubmed: 30643649
BMC Infect Dis. 2017 Apr 5;17(1):248
pubmed: 28381239
Hum Vaccin Immunother. 2016;12(2):375-82
pubmed: 26367344
Pediatr Infect Dis J. 1999 Jun;18(6):517-23
pubmed: 10391181
Infect Chemother. 2015 Dec;47(4):225-30
pubmed: 26788405
Cureus. 2018 Sep 22;10(9):e3343
pubmed: 30473976
3 Biotech. 2016 Dec;6(2):166
pubmed: 28330238
PLoS One. 2018 May 10;13(5):e0196722
pubmed: 29746496
Braz J Infect Dis. 2019 Jan - Feb;23(1):8-14
pubmed: 30849330
BMC Infect Dis. 2016 May 20;16:216
pubmed: 27206423
J Trop Pediatr. 2002 Oct;48(5):285-93
pubmed: 12405171
BMC Infect Dis. 2010 Mar 31;10:85
pubmed: 20356399
Clin Microbiol Infect. 2000 Jun;6(6):290-3
pubmed: 11168136
Can J Infect Dis Med Microbiol. 2018 Nov 1;2018:5406467
pubmed: 30515253
ISRN Otolaryngol. 2012 Oct 17;2012:813581
pubmed: 23762620
Epidemiol Infect. 2016 Nov;144(15):3226-3236
pubmed: 27405603
Eur J Clin Microbiol Infect Dis. 2007 Feb;26(2):83-90
pubmed: 17235554
Arch Otolaryngol Head Neck Surg. 2005 May;131(5):383-7
pubmed: 15897415
Braz J Microbiol. 2010 Jan;41(1):24-7
pubmed: 24031458
PLoS One. 2010 Mar 01;5(3):e9452
pubmed: 20209109
Clin Microbiol Infect. 2004 Sep;10(9):797-803
pubmed: 15355410
Med Sci Monit. 2013 Jan 18;19:54-60
pubmed: 23328644
Int J Pediatr Otorhinolaryngol. 2006 Dec;70(12):2099-102
pubmed: 16962178
J Family Med Prim Care. 2019 Oct 31;8(10):3130-3135
pubmed: 31742131
Germs. 2018 Sep 03;8(3):134-139
pubmed: 30250832
PLoS One. 2016 Dec 1;11(12):e0167725
pubmed: 27907156
J Family Community Med. 2002 May;9(2):23-6
pubmed: 23008668
J Clin Microbiol. 2006 Jul;44(7):2593-4
pubmed: 16825390
Singapore Med J. 2006 Apr;47(4):271-5
pubmed: 16572236
GMS Curr Top Otorhinolaryngol Head Neck Surg. 2014 Dec 01;13:Doc07
pubmed: 25587367
J Laryngol Otol. 2017 Nov;131(11):977-981
pubmed: 28874208
J Clin Microbiol. 2013 May;51(5):1614-6
pubmed: 23486716
Int J Pediatr Otorhinolaryngol. 1988 May;15(2):157-62
pubmed: 3397235
Braz J Otorhinolaryngol. 2008 Nov-Dec;74(6):903-911
pubmed: 19582348
Infect Immun. 2004 Nov;72(11):6689-93
pubmed: 15501804
Can J Infect Dis Med Microbiol. 2018 Jun 06;2018:7258672
pubmed: 29983836
BMC Res Notes. 2019 May 29;12(1):306
pubmed: 31142367
J Med Microbiol. 2006 Aug;55(Pt 8):989-992
pubmed: 16849717
BMC Res Notes. 2019 Sep 10;12(1):564
pubmed: 31500654
JNMA J Nepal Med Assoc. 2010 Apr-Jun;49(178):139-42
pubmed: 21485600
BMJ Open. 2017 Jan 17;7(1):e012992
pubmed: 28096254
Epidemiol Infect. 2000 Feb;124(1):47-51
pubmed: 10722129
BMC Infect Dis. 2019 Dec 2;19(1):1023
pubmed: 31791276