Anti-BCMA novel therapies for multiple myeloma.
BCMA
CART
Multiple myeloma
belantamab
teclistamab
Journal
Cancer drug resistance (Alhambra, Calif.)
ISSN: 2578-532X
Titre abrégé: Cancer Drug Resist
Pays: United States
ID NLM: 101738710
Informations de publication
Date de publication:
2023
2023
Historique:
received:
05
12
2022
revised:
28
01
2023
accepted:
03
03
2023
medline:
18
4
2023
entrez:
17
4
2023
pubmed:
18
4
2023
Statut:
epublish
Résumé
Recent advances in multiple myeloma therapy have increased the depth of response and ultimately survivals; however, the prognosis remains poor. The BCMA antigen is highly expressed in myeloma cells, thus representing a target for novel therapies. Several agents that target BCMA through different mechanisms, including bispecific T cell engagers drug conjugated to antibody and CAR-T cells, are now available or under development. Immunotherapies targeting BCMA have shown good results in efficacy and safety in multiple myeloma patients previously treated with several lines of therapy. This review will discuss the recent development of anti-BCMA targeted treatments in myeloma, with a special focus on currently available agents.
Identifiants
pubmed: 37065871
doi: 10.20517/cdr.2022.138
pmc: PMC10099603
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
169-181Informations de copyright
© The Author(s) 2023.
Déclaration de conflit d'intérêts
All authors declared that there are no conflicts of interest.
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