Disseminated Cryptococcosis Following Eculizumab Therapy: Insight Into Pathogenesis.
aHUS
atypical hemolytic uremic syndrome
complement component c5
cryptococcosis
eculizumab
pathogenesis
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
03
10
2022
accepted:
22
03
2023
medline:
18
4
2023
entrez:
17
4
2023
pubmed:
18
4
2023
Statut:
epublish
Résumé
Eculizumab, a recombinant humanized monoclonal antibody (mAb), is used for the treatment of patients (both adults and children) with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. This mAb binds to complement protein 5 (C5), thereby inhibiting its cleavage. On the other hand, one of the C5 cleavage products, C5a, is a potent anaphylatoxin with proinflammatory properties, involved in antimicrobial surveillance. Administration of eculizumab has been reported to make patients more susceptible to infection by encapsulated bacteria. Here, we are reporting an adult case of disseminated infection due to the encapsulated yeast
Identifiants
pubmed: 37065989
doi: 10.1093/ofid/ofad159
pii: ofad159
pmc: PMC10099467
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofad159Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
Déclaration de conflit d'intérêts
Potential conflicts of interest. For all the authors, there is no conflict to declare.
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