Control of working memory maintenance by theta-gamma phase amplitude coupling of human hippocampal neurons.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
07 Apr 2023
Historique:
pubmed: 18 4 2023
medline: 18 4 2023
entrez: 17 4 2023
Statut: epublish

Résumé

Retaining information in working memory (WM) is a demanding process that relies on cognitive control to protect memoranda-specific persistent activity from interference. How cognitive control regulates WM storage, however, remains unknown. We hypothesized that interactions of frontal control and hippocampal persistent activity are coordinated by theta-gamma phase amplitude coupling (TG-PAC). We recorded single neurons in the human medial temporal and frontal lobe while patients maintained multiple items in WM. In the hippocampus, TG-PAC was indicative of WM load and quality. We identified cells that selectively spiked during nonlinear interactions of theta phase and gamma amplitude. These PAC neurons were more strongly coordinated with frontal theta activity when cognitive control demand was high, and they introduced information-enhancing and behaviorally relevant noise correlations with persistently active neurons in the hippocampus. We show that TG-PAC integrates cognitive control and WM storage to improve the fidelity of WM representations and facilitate behavior.

Identifiants

DOI: 10.1101/2023.04.05.535772 PMID: 37066145 PMC: PMC10104113
pubmed: 37066145
doi: 10.1101/2023.04.05.535772
pmc: PMC10104113
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH110831
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS117839
Pays : United States

Déclaration de conflit d'intérêts

Competing Interests Statement Authors declare no competing interests.

Auteurs

Jonathan Daume (J)

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Jan Kaminski (J)

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Nencki Institute of Experimental Biology, Warsaw, Poland.

Andrea G P Schjetnan (AGP)

Krembil Research Institute and Division of Neurosurgery, University Health Network (UHN), University of Toronto, Toronto, ON, Canada.

Yousef Salimpour (Y)

Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Umais Khan (U)

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Chrystal Reed (C)

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

William Anderson (W)

Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Taufik A Valiante (TA)

Krembil Research Institute and Division of Neurosurgery, University Health Network (UHN), University of Toronto, Toronto, ON, Canada.

Adam N Mamelak (AN)

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Ueli Rutishauser (U)

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Classifications MeSH