Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
03 Apr 2023
03 Apr 2023
Historique:
medline:
18
4
2023
entrez:
17
4
2023
pubmed:
18
4
2023
Statut:
epublish
Résumé
Little is known about circular RNAs (circRNAs) in specific brain cells and human neuropsychiatric disease. Here, we systematically identified over 11,039 circRNAs expressed in vulnerable dopamine and pyramidal neurons laser-captured from 190 human brains and non-neuronal cells using ultra-deep, total RNA sequencing. 1,526 and 3,308 circRNAs were custom-tailored to the cell identity of dopamine and pyramidal neurons and enriched in synapse pathways. 88% of Parkinson's and 80% of Alzheimer's disease-associated genes produced circRNAs.
Identifiants
pubmed: 37066229
doi: 10.1101/2023.04.01.535194
pmc: PMC10103951
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NINDS NIH HHS
ID : U01 NS100603
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS082157
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS072026
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS115144
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057331
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072980
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS095736
Pays : United States
Commentaires et corrections
Type : UpdateIn
Références
Ann Neurol. 2016 Feb;79(2):335-7
pubmed: 26703368
Nature. 2020 Jul;583(7818):711-719
pubmed: 32728246
PLoS One. 2012;7(2):e30733
pubmed: 22319583
Lancet Neurol. 2019 Dec;18(12):1091-1102
pubmed: 31701892
Nat Biotechnol. 2013 Nov;31(11):1015-22
pubmed: 24037425
PLoS Comput Biol. 2017 Jun 8;13(6):e1005420
pubmed: 28594838
Nat Neurosci. 2019 Nov;22(11):1903-1912
pubmed: 31591557
Mol Neurodegener. 2019 Aug 2;14(1):32
pubmed: 31375134
Nat Genet. 2012 Apr 29;44(6):636-8
pubmed: 22544367
Nat Struct Mol Biol. 2015 Mar;22(3):256-64
pubmed: 25664725
Nat Commun. 2022 Jun 10;13(1):3242
pubmed: 35688820
Ann Neurol. 2016 Feb;79(2):244-56
pubmed: 26528954
Science. 2017 Sep 22;357(6357):
pubmed: 28798046
Nature. 1995 Dec 7;378(6557):632-5
pubmed: 8524399
Science. 2002 Oct 25;298(5594):789-91
pubmed: 12399581
Nucleic Acids Res. 2016 Feb 18;44(3):1370-83
pubmed: 26657629
Neurology. 2001 Jan 9;56(1):127-9
pubmed: 11148253
Nat Neurosci. 2015 Apr;18(4):603-610
pubmed: 25714049
Neurology. 2007 May 1;68(18):1501-8
pubmed: 17470753
Neurobiol Aging. 1997 Jul-Aug;18(4 Suppl):S1-2
pubmed: 9330978
Brain. 2022 Dec 19;145(12):4349-4367
pubmed: 36074904
Mol Psychiatry. 2020 Nov;25(11):2712-2727
pubmed: 31988434
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Genome Biol. 2014;15(12):550
pubmed: 25516281
Acta Neuropathol Commun. 2022 Mar 4;10(1):29
pubmed: 35246267
Nat Commun. 2016 Apr 06;7:11215
pubmed: 27050392
Nat Protoc. 2012 Mar 01;7(3):562-78
pubmed: 22383036
Front Aging Neurosci. 2017 Oct 10;9:330
pubmed: 29066967
Science. 2014 May 2;344(6183):519-23
pubmed: 24786080
Neurology. 2006 May 9;66(9):1455; author reply 1455
pubmed: 16682691
Arch Neurol. 2008 Aug;65(8):1074-80
pubmed: 18695057
Trends Mol Med. 2022 Apr;28(4):343-344
pubmed: 35232670
Lancet. 2021 Jun 12;397(10291):2284-2303
pubmed: 33848468
Nucleic Acids Res. 2017 Jan 4;45(D1):D833-D839
pubmed: 27924018
PLoS One. 2012;7(5):e36458
pubmed: 22563501
Genome Biol. 2014;15(12):555
pubmed: 25514851
Nature. 2017 Jun 29;546(7660):656-661
pubmed: 28636593
J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4
pubmed: 1564476
Gene. 2019 Jul 30;707:30-35
pubmed: 31055022
Front Biol (Beijing). 2016 Oct;11(5):376-386
pubmed: 28974957
Oncogene. 2014 Jun 26;33(26):3351-60
pubmed: 23851492
Nucleic Acids Res. 2006 May 08;34(8):e63
pubmed: 16682442
RNA Biol. 2022 Jan;19(1):176-190
pubmed: 35067193
Nat Neurosci. 2018 Oct;21(10):1482-1492
pubmed: 30224808
J Cancer. 2021 Jun 26;12(17):5206-5219
pubmed: 34335937
Bioinformatics. 2009 May 1;25(9):1105-11
pubmed: 19289445
Mol Cell. 2015 Jun 4;58(5):870-85
pubmed: 25921068
EMBO Mol Med. 2020 Nov 6;12(11):e13551
pubmed: 33438831
Sci Rep. 2016 Dec 13;6:38907
pubmed: 27958329
Mov Disord. 2016 Jun;31(6):802-13
pubmed: 27193205
Genome Res. 2016 Sep;26(9):1277-87
pubmed: 27365365
Nature. 2013 Mar 21;495(7441):333-8
pubmed: 23446348
Brain Res. 2010 Jun 18;1338:20-35
pubmed: 20380817
Nucleic Acids Res. 2016 Apr 7;44(6):e58
pubmed: 26657634
Nat Neurosci. 2021 May;24(5):622-632
pubmed: 33510479
Cell. 2007 Jun 29;129(7):1401-14
pubmed: 17604727
Nat Genet. 2012 Apr 29;44(6):639-41
pubmed: 22544363
Cell Rep. 2014 Dec 11;9(5):1966-1980
pubmed: 25544350
Signal Transduct Target Ther. 2021 May 21;6(1):185
pubmed: 34016945
Clin Chem. 2005 Oct;51(10):1973-81
pubmed: 16123149
Cell. 2018 Jul 12;174(2):350-362.e17
pubmed: 29887379
Genome Biol. 2011 Aug 11;12(8):R72
pubmed: 21835007
Cell Rep. 2019 Mar 19;26(12):3444-3460.e5
pubmed: 30893614
RNA. 2013 Feb;19(2):141-57
pubmed: 23249747
Nat Genet. 2019 Mar;51(3):404-413
pubmed: 30617256
Trends Genet. 2010 Jan;26(1):21-8
pubmed: 19944475
Genome Med. 2020 Dec 7;12(1):112
pubmed: 33287884
Nature. 2013 Mar 21;495(7441):384-8
pubmed: 23446346
BMC Biotechnol. 2015 Jul 30;15:65
pubmed: 26223446
Acta Neuropathol. 2009 Jun;117(6):613-34
pubmed: 19399512
Neurobiol Aging. 2006 Oct;27(10):1372-84
pubmed: 16289476
Front Physiol. 2018 Mar 20;9:240
pubmed: 29615932
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13052-7
pubmed: 19628698
Nat Biotechnol. 2014 May;32(5):453-61
pubmed: 24811520
BMC Mol Biol. 2006 Jan 31;7:3
pubmed: 16448564
Nat Genet. 2021 Jun;53(6):787-793
pubmed: 33958783
Mol Cell. 2013 Sep 26;51(6):792-806
pubmed: 24035497