Dynamic molecular mechanism of the nuclear pore complex permeability barrier.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
14 Apr 2023
Historique:
pubmed: 18 4 2023
medline: 18 4 2023
entrez: 17 4 2023
Statut: epublish

Résumé

Nuclear pore complexes (NPCs) mediate nucleocytoplasmic transport of specific macromolecules while impeding the exchange of unsolicited material. However, key aspects of this gating mechanism remain controversial. To address this issue, we determined the nanoscopic behavior of the permeability barrier directly within yeast

Identifiants

DOI: 10.1101/2023.03.31.535055 PMID: 37066338 PMC: PMC10103940
pubmed: 37066338
doi: 10.1101/2023.03.31.535055
pmc: PMC10103940
pii:
doi:

Types de publication

Preprint

Langues

eng

Auteurs

Toshiya Kozai (T)

Biozentrum, University of Basel, Switzerland.
Swiss Nanoscience Institute, University of Basel, Switzerland.

Javier Fernandez-Martinez (J)

Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, U.S.A.
Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, 48940, Leioa, Spain.

Trevor van Eeuwen (T)

Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, U.S.A.

Paola Gallardo (P)

European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Netherlands.

Larisa E Kapinos (LE)

Biozentrum, University of Basel, Switzerland.

Adam Mazur (A)

Biozentrum, University of Basel, Switzerland.

Wenzhu Zhang (W)

Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, U.S.A.

Jeremy Tempkin (J)

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, U.S.A. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA. Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

Radhakrishnan Panatala (R)

Biozentrum, University of Basel, Switzerland.

Maria Delgado-Izquierdo (M)

Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, 48940, Leioa, Spain.

Barak Raveh (B)

School of Computer Science and Engineering, The Hebrew University of Jerusalem, Israel.

Andrej Sali (A)

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, U.S.A. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA. Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

Brian T Chait (BT)

Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, U.S.A.

Liesbeth M Veenhoff (LM)

European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Netherlands.

Michael P Rout (MP)

Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, U.S.A.

Roderick Y H Lim (RYH)

Biozentrum, University of Basel, Switzerland.
Swiss Nanoscience Institute, University of Basel, Switzerland.

Classifications MeSH