Disparities in care of pediatric, adolescent, and young adult patients with solid tumors: A systematic review.
disparities
ethnicity
pediatric
race
socioeconomic factors
surgical oncology
systematic review
Journal
Pediatric blood & cancer
ISSN: 1545-5017
Titre abrégé: Pediatr Blood Cancer
Pays: United States
ID NLM: 101186624
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
14
03
2023
received:
14
11
2022
accepted:
18
03
2023
medline:
25
5
2023
pubmed:
18
4
2023
entrez:
17
4
2023
Statut:
ppublish
Résumé
Numerous studies have demonstrated a variety of social inequalities within pediatric and young adult patients with solid tumors. This systematic review examines and consolidates the existing literature regarding disparities in pediatric and young adult solid tumor oncology. A MeSH search was performed on the following databases: MEDLINE, PubMed, OvidSP Cochrane, Central, Embase, Cinhal, and Scopus. The systematic review was performed using Rayyan QCRI. Total 387 articles were found on the initial search, and 34 articles were included in final review. Twenty-seven studies addressed racial and ethnic disparities; 23 addressed socioeconomic disparities. Patients with Hispanic ethnicity, Black race, and lower socioeconomic status were more likely to present at later stages, have differences in treatments and higher mortality rates. This qualitative systematic review identified both racial and socioeconomic disparities in pediatric cancer patients across a variety of solid tumor types. Patients with Hispanic ethnicity, Black race, and lower socioeconomic status are associated with disparities in stage at presentation, treatment, and outcome. Characterization of existing disparities provides the evidence necessary to support changes at a systemic level.
Sections du résumé
BACKGROUND
Numerous studies have demonstrated a variety of social inequalities within pediatric and young adult patients with solid tumors. This systematic review examines and consolidates the existing literature regarding disparities in pediatric and young adult solid tumor oncology.
PROCEDURE
A MeSH search was performed on the following databases: MEDLINE, PubMed, OvidSP Cochrane, Central, Embase, Cinhal, and Scopus. The systematic review was performed using Rayyan QCRI.
RESULTS
Total 387 articles were found on the initial search, and 34 articles were included in final review. Twenty-seven studies addressed racial and ethnic disparities; 23 addressed socioeconomic disparities. Patients with Hispanic ethnicity, Black race, and lower socioeconomic status were more likely to present at later stages, have differences in treatments and higher mortality rates.
CONCLUSION
This qualitative systematic review identified both racial and socioeconomic disparities in pediatric cancer patients across a variety of solid tumor types. Patients with Hispanic ethnicity, Black race, and lower socioeconomic status are associated with disparities in stage at presentation, treatment, and outcome. Characterization of existing disparities provides the evidence necessary to support changes at a systemic level.
Types de publication
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e30355Informations de copyright
© 2023 Wiley Periodicals LLC.
Références
Nizam W, Yeo HL, Obeng-Gyasi S, Brock MV, Johnston FM. Disparities in surgical oncology: management of advanced cancer. Ann Surg Oncol. 2021;28(13):8056-8073. doi:10.1245/s10434-021-10275-9
Rhodin KE, Hong CS, Olivere LA, et al. Implementation of a surgical oncology disparities curriculum for preclinical medical students. J Surg Res. 2020;253:214-223. doi:10.1016/j.jss.2020.03.058
Aristizabal P, Winestone LE, Umaretiya P, Bona K. Disparities in pediatric oncology: the 21st century opportunity to improve outcomes for children and adolescents with cancer. Am Soc Clin Oncol Educ Book. 2021;41:e315-e326. doi:10.1200/EDBK_320499
Bhatia S. Disparities in cancer outcomes: Lessons learned from children with cancer. Pediatr Blood Cancer. 2011;56(6):994-1002. doi:10.1002/pbc.23078
COG Homepage. Children's Oncology Group. Accessed August 28, 2022. https://childrensoncologygroup.org/
Withycombe JS, Alonzo TA, Wilkins-Sanchez MA, Hetherington M, Adamson PC, Landier W. The Children's Oncology Group: organizational structure, membership, and institutional characteristics. J Pediatr Oncol Nurs. 2019;36(1):24-34. doi:10.1177/1043454218810141
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan - a web and mobile app for systematic reviews. Syst Rev. 2016;5:210. doi:10.1186/s13643-016-0384-4
Sayers A. Tips and tricks in performing a systematic review. Br J Gen Pract. 2007;57(542):759.
Fiscella K, Williams DR. Health disparities based on socioeconomic inequities: implications for urban health care. Acad Med. 2004;79(12):1139-1147. doi:10.1097/00001888-200412000-00004
Bonito AJ, Bann C, Eicheldinger C, Carpenter L. Creation of new race-ethnicity codes and socioeconomic status (SES) indicators for Medicare beneficiaries. RTI Int Agency Healthcare Research and Quality; 2008.
Cancer staging - NCI. NCI; March 9, 2015. Accessed January 18, 2023. https://www.cancer.gov/about-cancer/diagnosis-staging/staging
Ottawa Hospital Research Institute. Accessed January 12, 2023. https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
Burns PB, Rohrich RJ, Chung KC. The levels of evidence and their role in evidence-based medicine. Plast Reconstr Surg. 2011;128(1):305-310. doi:10.1097/PRS.0b013e318219c171
Sadler C, Goldfarb M. Comparison of primary and secondary breast cancers in adolescents and young adults. Cancer. 2015;121(8):1295-1302. doi:10.1002/cncr.29200
Shavers VL, Harlan LC, Stevens JL. Racial/ethnic variation in clinical presentation, treatment, and survival among breast cancer patients under age 35. Cancer. 2003;97(1):134-147. doi:10.1002/cncr.11051
Jain U, Jain B, Fayanju OM, Chino F, Dee EC. Disparities in timely treatment among young women with breast cancer. Am J Surg. 2022;224(2):811-815. doi:10.1016/j.amjsurg.2022.01.019
Austin MT, Hamilton E, Zebda D, et al. Health disparities and impact on outcomes in children with primary central nervous system solid tumors. J Neurosurg Pediatr. 2016;18(5):585-593. doi:10.3171/2016.5.PEDS15704
Dressler EV, Dolecek TA, Liu M, Villano JL. Demographics, patterns of care, and survival in pediatric medulloblastoma. J Neurooncol. 2017;132(3):497-506. doi:10.1007/s11060-017-2400-5
Mukherjee D, Kosztowski T, Zaidi HA, et al. Disparities in access to pediatric neurooncological surgery in the United States. Pediatrics. 2009;124(4):e688-696. doi:10.1542/peds.2009-0377
Galadima HI, Adunlin G, Hughes MS, Cropp CD, Lucero L, Akpinar-Elci M. Racial disparities and treatment trends among young-onset colorectal cancer patients: an analysis of a hospital cancer registry. Cancer Epidemiol. 2021;72:101911. doi:10.1016/j.canep.2021.101911
Lee DY, Teng A, Pedersen RC, et al. Racial and Socioeconomic Treatment Disparities in Adolescents and Young Adults with Stage II-III Rectal Cancer. Ann Surg Oncol. 2017;24(2):311-318. doi:10.1245/s10434-016-5626-0
Sloane D, Chen H, Howell C. Racial disparity in primary hepatocellular carcinoma: tumor stage at presentation, surgical treatment and survival. J Natl Med Assoc. 2006;98(12):1934-1939.
Hamilton EC, Nguyen HT, Chang YC, et al. Health disparities influence childhood melanoma stage at diagnosis and outcome. J Pediatr. 2016;175:182-187. doi:10.1016/j.jpeds.2016.04.068
Henderson TO, Bhatia S, Pinto N, et al. Racial and ethnic disparities in risk and survival in children with neuroblastoma: a Children's Oncology Group study. J Clin Oncol. 2011;29(1):76-82. doi:10.1200/JCO.2010.29.6103
Gutierrez JC, Koniaris LG, Cheung MC, Byrne MM, Fischer AC, Sola JE. Cancer care in the pediatric surgical patient: a paradigm to abolish volume-outcome disparities in surgery. Surgery. 2009;145(1):76-85. doi:10.1016/j.surg.2008.08.011
Bona K, Li Y, Winestone LE, et al. Poverty and targeted immunotherapy: survival in Children's Oncology Group clinical trials for high-risk Neuroblastoma. J Natl Cancer Inst. 2021;113(3):282-291. doi:10.1093/jnci/djaa107
Bownes LV, Stafman LL, Maizlin II, et al. Socioeconomic disparities affect survival in malignant ovarian germ cell tumors in AYA population. J Surg Res. 2018;222:180-186.e3. doi:10.1016/j.jss.2017.09.013
Gonzalez DO, Cooper JN, Aldrink JH, et al. Variability in surgical management of benign ovarian neoplasms in children. J Pediatr Surg. 2017;52(6):944-950. doi:10.1016/j.jpedsurg.2017.03.014
Stafman LL, Maizlin II, Dellinger M, et al. Disparities in fertility-sparing surgery in adolescent and young women with stage I ovarian dysgerminoma. J Surg Res. 2018;224:38-43. doi:10.1016/j.jss.2017.11.046
Truong B, Green AL, Friedrich P, Ribeiro KB, Rodriguez-Galindo C. Ethnic, racial, and socioeconomic disparities in retinoblastoma. JAMA Pediatr. 2015;169(12):1096-1104. doi:10.1001/jamapediatrics.2015.2360
Jacobs AJ, Lindholm EB, Levy CF, Fish JD, Glick RD. Racial and ethnic disparities in treatment and survival of pediatric sarcoma. J Surg Res. 2017;219:43-49. doi:10.1016/j.jss.2017.05.031
Joseph M, Hamilton EC, Hayes-Jordan A, Huh WW, Austin MT. The impact of racial/ethnic disparities on survival for children and adolescents with extremity sarcomas: a population-based study. J Pediatr Surg. 2017;53(1):169-173. doi:10.1016/j.jpedsurg.2017.10.034
Jawad MU, Pollock BH, Alvarez E, Carr-Ascher JR, Randall RL, Thorpe SW. Non-private health insurance predicts advanced stage at presentation and amputation in lower extremity high grade bone sarcoma: a National Cancer Database Study: amputation predicts survival: an effect most pronounced in pediatric and AYA age group. Ann Surg Oncol. 2022;29(7):4363-4372. doi:10.1245/s10434-022-11494-4
Dilday JC, Nelson DW, Fischer TD, Goldfarb M. Disparities in amputation rates for non-metastatic extremity soft tissue sarcomas and the impact on survival. Ann Surg Oncol. 2021;28(1):576-584. doi:10.1245/s10434-020-08586-4
Avila JC, Livingston JA, Rodriguez AM, Kirchhoff AC, Kuo YF, Kaul S. Disparities in adolescent and young adult sarcoma survival: analyses of the Texas Cancer Registry and the National SEER Data. J Adolesc Young Adult Oncol. 2018;7(6):681-687. doi:10.1089/jayao.2018.0034
Deziel NC, Zhang Y, Wang R, et al. Birth characteristics and risk of pediatric thyroid cancer: a population-based record-linkage study in california. Thyroid. 2021;31(4):596-606. doi:10.1089/thy.2020.0217
Goldfarb M, Freyer DR. Comparison of secondary and primary thyroid cancer in adolescents and young adults. Cancer. 2014;120(8):1155-1161. doi:10.1002/cncr.28463
Oktay K, Harvey BE, Partridge AH, et al. Fertility preservation in patients with cancer: ASCO clinical practice guideline update. J Clin Oncol. 2018;36(19):1994-2001. doi:10.1200/JCO.2018.78.1914
Gruszczynski NR, Low CM, Choby G, Meister KD, Smith BH, Balakrishnan K. Effects of social determinants of health care on pediatric thyroid cancer outcomes in the United States. Otolaryngol Head Neck Surg. 2022;166(6):1045-1054. doi:10.1177/01945998211032901
Raval MV, Bentrem DJ, Stewart AK, Ko CY, Reynolds M. Utilization of total thyroidectomy for differentiated thyroid cancer in children. Ann Surg Oncol. 2010;17(10):2545-2553. doi:10.1245/s10434-010-1083-3
Amirian ES. The role of Hispanic ethnicity in pediatric Wilms’ tumor survival. Pediatr Hematol Oncol. 2013;30(4):317-327. doi:10.3109/08880018.2013.775618
Austin MT, Nguyen H, Eberth JM, et al. Health disparities are important determinants of outcome for children with solid tumor malignancies. J Pediatr Surg. 2015;50(1):161-166. doi:10.1016/j.jpedsurg.2014.10.037
Caplin DA, Smith KR, Ness KK, et al. Effect of population socioeconomic and health system factors on medical care of childhood cancer survivors: a report from the Childhood Cancer Survivor Study. J Adolesc Young Adult Oncol. 2017;6(1):74-82. doi:10.1089/jayao.2016.0016
Letourneau JM, Smith JF, Ebbel EE, et al. Racial, socioeconomic, and demographic disparities in access to fertility preservation in young women diagnosed with cancer. Cancer. 2012;118(18):4579-4588. doi:10.1002/cncr.26649
Goodman LR, Balthazar U, Kim J, Mersereau JE. Trends of socioeconomic disparities in referral patterns for fertility preservation consultation. Hum Reprod. 2012;27(7):2076-2081. doi:10.1093/humrep/des133
Shnorhavorian M, Harlan LC, Smith AW, et al. Fertility preservation knowledge, counseling, and actions among adolescent and young adult patients with cancer: a population-based study. Cancer. 2015;121(19):3499-3506. doi:10.1002/cncr.29328
Bann CM, Treiman K, Squiers L, et al. Cancer survivors’ use of fertility preservation. J Womens Health 2002. 2015;24(12):1030-1037. doi:10.1089/jwh.2014.5160
Williams DR, Mohammed SA, Leavell J, Race CC, Socioeconomic status and health: complexities, ongoing challenges and research opportunities. Ann N Y Acad Sci. 2010;1186:69-101. doi:10.1111/j.1749-6632.2009.05339.x
Hirschl RB, Newman E, Cooke-Barber J, Garcia V. APSA 5.0: saving even more lifetimes the Jay and Margie Grosfeld presidential symposium. J Pediatr Surg. 2020;55(1):2-17. doi:10.1016/j.jpedsurg.2019.10.004
Probst JC, Moore CG, Glover SH, Samuels ME. Person and place: the compounding effects of race/ethnicity and rurality on health. Am J Public Health. 2004;94(10):1695-1703.
Zogg CK, Jiang W, Chaudhary MA, et al. Racial disparities in emergency general surgery: do differences in outcomes persist among universally insured military patients? J Trauma Acute Care Surg. 2016;80(5):764-775;discussion 775-777. doi:10.1097/TA.0000000000001004
Children's Health Insurance Program (CHIP). Medicaid. Accessed August 12, 2022. https://www.medicaid.gov/chip/index.html
Lund MJ, Eliason MT, Haight AE, Ward KC, Young JL, Pentz RD. Racial/ethnic diversity in children's oncology clinical trials: ten years later. Cancer. 2009;115(16):3808-3816. doi:10.1002/cncr.24437
Faulk KE, Anderson-Mellies A, Cockburn M, Green AL. Assessment of enrollment characteristics for Children's Oncology Group (COG) upfront therapeutic clinical trials 2004-2015. PLoS One. 2020;15(4):e0230824. doi:10.1371/journal.pone.0230824
Brown AL, Sok P, Scheurer ME, et al. An updated assessment of 43,110 patients enrolled in the Childhood Cancer Research Network: a Children's Oncology Group report. Cancer. 2022;128(14):2760-2767. doi:10.1002/cncr.34248
Aristizabal P, Singer J, Cooper R, et al. Participation in pediatric oncology research protocols: Racial/ethnic, language and age-based disparities. Pediatr Blood Cancer. 2015;62(8):1337-1344. doi:10.1002/pbc.25472
Musselman JRB, Spector LG, Krailo MD, et al. The Children's Oncology Group Childhood Cancer Research Network (CCRN): case catchment in the United States. Cancer. 2014;120(19):3007-3015. doi:10.1002/cncr.28813
Chow EJ, Winestone LE, Lupo PJ, et al. Leveraging clinical trial populations and data from the Children's Oncology Group for cancer survivorship research. Cancer Epidemiol Biomarkers Prev. 2022;31(9):1675-1682. doi:10.1158/1055-9965.EPI-22-0125
Mittal N, Davidson J, Martinez MF, et al. A tri-institutional approach to address disparities in Children's Oncology Group clinical trial accrual for adolescents and young adults and underrepresented minorities. J Adolesc Young Adult Oncol. 2019;8(3):227-235. doi:10.1089/jayao.2018.0119
Ehrlich PF, Hamilton TE, Gow K, et al. Surgical protocol violations in children with renal tumors provides an opportunity to improve pediatric cancer care: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2016;63(11):1905-1910. doi:10.1002/pbc.26083
Roth ME, O'Mara AM, Seibel NL, et al. Low enrollment of adolescents and young adults onto cancer trials: insights from the community clinical oncology program. J Oncol Pract. 2016;12(4):e388-395. doi:10.1200/JOP.2015.009084
Mittal N, Langevin AM, Kyono W, et al. Barriers to pediatric oncologist enrollment of adolescents and young adults on a cross-network National Clinical Trials Network Supportive Care Cancer Clinical Trial. J Adolesc Young Adult Oncol. 2022;11(1):117-121. doi:10.1089/jayao.2021.0041