Prognostic significance of HER2-low status in HR-positive/HER2-negative advanced breast cancer treated with CDK4/6 inhibitors.
Journal
NPJ breast cancer
ISSN: 2374-4677
Titre abrégé: NPJ Breast Cancer
Pays: United States
ID NLM: 101674891
Informations de publication
Date de publication:
17 Apr 2023
17 Apr 2023
Historique:
received:
16
12
2022
accepted:
04
04
2023
medline:
18
4
2023
entrez:
17
4
2023
pubmed:
18
4
2023
Statut:
epublish
Résumé
Whether Human Epidermal growth factor Receptor 2 (HER2)-low status has prognostic significance in HR + /HER2- advanced Breast Cancer (aBC) patients treated with first-line Endocrine Therapy plus CDK 4/6 inhibitors remains unclear. In 428 patients evaluated, HER2-low status was independently associated with significantly worse PFS and OS when compared with HER2-0 status. Based on our findings, HER2-low status could become a new prognostic biomarker in this clinical setting.
Identifiants
pubmed: 37069173
doi: 10.1038/s41523-023-00534-1
pii: 10.1038/s41523-023-00534-1
pmc: PMC10110597
doi:
Types de publication
Journal Article
Langues
eng
Pagination
27Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
JAMA Netw Open. 2021 Nov 1;4(11):e2133132
pubmed: 34739066
J Clin Oncol. 2020 Jun 10;38(17):1951-1962
pubmed: 32330069
NPJ Breast Cancer. 2022 Dec 20;8(1):131
pubmed: 36539444
JCO Oncol Pract. 2022 May;18(5):319-327
pubmed: 34637323
NPJ Breast Cancer. 2021 Jan 4;7(1):1
pubmed: 33397968
Cancers (Basel). 2022 Oct 11;14(20):
pubmed: 36291765
JAMA Oncol. 2022 Aug 1;8(8):1177-1183
pubmed: 35737367
NPJ Breast Cancer. 2021 Oct 12;7(1):137
pubmed: 34642348
JAMA Netw Open. 2022 Sep 1;5(9):e2231170
pubmed: 36107428
Lancet Oncol. 2021 Aug;22(8):1151-1161
pubmed: 34252375
Breast. 2021 Dec;60:62-69
pubmed: 34481367
Cancer Diagn Progn. 2022 May 3;2(3):316-323
pubmed: 35530657
Cancers (Basel). 2022 Dec 25;15(1):
pubmed: 36612123
Front Endocrinol (Lausanne). 2022 Aug 18;13:1000704
pubmed: 36060981
N Engl J Med. 2022 Jul 7;387(1):9-20
pubmed: 35665782