Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.

Humans Endothelial Cells / pathology Genome-Wide Association Study Cerebral Small Vessel Diseases / diagnostic imaging Stroke Magnetic Resonance Imaging / methods Genomics

Journal

Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015

Informations de publication

Date de publication:
04 2023
Historique:
received: 10 10 2021
accepted: 15 02 2023
medline: 21 4 2023
pubmed: 18 4 2023
entrez: 17 4 2023
Statut: ppublish

Résumé

Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly in the white matter. These were associated with white matter PVS already in young adults (N = 1,748; 22.1 ± 2.3 yr) and were enriched in early-onset leukodystrophy genes and genes expressed in fetal brain endothelial cells, suggesting early-life mechanisms. In total, 53% of white matter PVS risk loci showed nominally significant associations (27% after multiple-testing correction) in a Japanese population-based cohort (N = 2,862; 68.3 ± 5.3 yr). Mendelian randomization supported causal associations of high blood pressure with basal ganglia and hippocampal PVS, and of basal ganglia PVS and hippocampal PVS with stroke, accounting for blood pressure. Our findings provide insight into the biology of PVS and cerebral small vessel disease, pointing to pathways involving extracellular matrix, membrane transport and developmental processes, and the potential for genetically informed prioritization of drug targets.

Identifiants

DOI: 10.1038/s41591-023-02268-w PMID: 37069360 PMC: PMC10115645
pubmed: 37069360
doi: 10.1038/s41591-023-02268-w
pii: 10.1038/s41591-023-02268-w
pmc: PMC10115645
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

950-962

Subventions

Organisme : NHLBI NIH HHS
ID : HHSN268201500001I
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG031287
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054076
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG049607
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG025941
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059725
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG049505
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG052409
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS017950
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/F019394/1
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom

Investigateurs

Quentin Le Grand (Q)

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2023. The Author(s).

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Auteurs

Marie-Gabrielle Duperron (MG)

Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.
Department of Neurology, Institute of Neurodegenerative Diseases, Bordeaux University Hospital, Bordeaux, France.
ORCID: 0000-0001-7408-7792

Maria J Knol (MJ)

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0002-3597-1531

Quentin Le Grand (Q)

Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.
ORCID: 0000-0002-9299-0747

Tavia E Evans (TE)

Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0003-2390-286X

Aniket Mishra (A)

Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.

Ami Tsuchida (A)

Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.
Groupe d'Imagerie Neurofonctionelle - Institut des maladies neurodégénératives (GIN-IMN), UMR 5293, University of Bordeaux, CNRS, CEA, Bordeaux, France.
ORCID: 0000-0001-5160-6203

Gennady Roshchupkin (G)

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0002-3403-2313

Takahiro Konuma (T)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.

David-Alexandre Trégouët (DA)

Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.

Jose Rafael Romero (JR)

Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
The Framingham Heart Study, Framingham, MA, USA.
ORCID: 0000-0002-1101-2950

Stefan Frenzel (S)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.

Michelle Luciano (M)

School of Psychology, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-7306-3008

Edith Hofer (E)

Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.

Mathieu Bourgey (M)

Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montreal, Quebec, Canada.
Canadian Centre for Computational Genomics, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0002-8432-834X

Nicole D Dueker (ND)

John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.

Pilar Delgado (P)

Institut de Recerca Vall d'hebron, Neurovascular Research Lab, Universitat Autònoma de Barcelona, Barcelona, Spain.
Hospital Universitari Vall d'Hebron, Neurology Department, Universitat Autònoma de Barcelona, Barcelona, Spain.

Saima Hilal (S)

Memory Aging and Cognition Center, National University Health System, Singapore, Singapore.
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.

Rick M Tankard (RM)

Department of Mathematics and Statistics, Curtin University, Perth, Western Australia, Australia.
ORCID: 0000-0002-8847-9401

Florian Dubost (F)

Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Jean Shin (J)

The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
ORCID: 0000-0001-7353-5178

Yasaman Saba (Y)

Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.
Institute for Molecular Biology & Biochemistry, Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Graz, Austria.
ORCID: 0000-0002-3549-2493

Nicola J Armstrong (NJ)

Department of Mathematics and Statistics, Curtin University, Perth, Western Australia, Australia.
ORCID: 0000-0002-4477-293X

Constance Bordes (C)

Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.
ORCID: 0000-0003-3367-1778

Mark E Bastin (ME)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Alexa Beiser (A)

Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
The Framingham Heart Study, Framingham, MA, USA.
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Henry Brodaty (H)

Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia.
Dementia Collaborative Research Centre Assessment and Better Care, UNSW, Sydney, New South Wales, Australia.
ORCID: 0000-0001-9487-6617

Robin Bülow (R)

Institute for Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
ORCID: 0000-0003-1884-5784

Caty Carrera (C)

Stroke Pharmacogenomics and Genetics Group, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.

Christopher Chen (C)

Memory Aging and Cognition Center, National University Health System, Singapore, Singapore.
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Ching-Yu Cheng (CY)

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Center for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ophthalmology & Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.
ORCID: 0000-0003-0655-885X

Ian J Deary (IJ)

School of Psychology, University of Edinburgh, Edinburgh, UK.

Piyush G Gampawar (PG)

Institute for Molecular Biology & Biochemistry, Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Graz, Austria.

Jayandra J Himali (JJ)

Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
The Framingham Heart Study, Framingham, MA, USA.
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA.
Department of Population Health Sciences, UT Health San Antonio, San Antonio, TX, USA.
ORCID: 0000-0003-1391-9481

Jiyang Jiang (J)

Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia.
ORCID: 0000-0002-2147-6302

Takahisa Kawaguchi (T)

Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Shuo Li (S)

The Framingham Heart Study, Framingham, MA, USA.
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
ORCID: 0000-0003-2331-2448

Melissa Macalli (M)

Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.
ORCID: 0000-0003-3008-8720

Pascale Marquis (P)

Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montreal, Quebec, Canada.
Canadian Centre for Computational Genomics, McGill University, Montreal, Quebec, Canada.

Zoe Morris (Z)

Neuroimaging, Department of Clinical Neurosciences, Royal Infirmary of Edinburgh, Edinburgh, UK.

Susana Muñoz Maniega (S)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
UK Dementia Research Institute Centre at the University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-5185-6384

Susumu Miyamoto (S)

Kyoto University Hospital, Kyoto, Japan.

Masakazu Okawa (M)

Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
ORCID: 0000-0002-5414-1293

Matthew Paradise (M)

Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia.

Pedram Parva (P)

The Framingham Heart Study, Framingham, MA, USA.
Radiology Department, Boston University School of Medicine, Boston, MA, USA.
Department of Radiology, Harvard Medical School, Boston, MA, USA.

Tatjana Rundek (T)

Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Evelyn F. McKnight Brain Institute, Department of Neurology, University of Miami, Miami, FL, USA.
ORCID: 0000-0002-7115-9815

Muralidharan Sargurupremraj (M)

Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.

Sabrina Schilling (S)

Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.

Kazuya Setoh (K)

Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.

Omar Soukarieh (O)

Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.

Yasuharu Tabara (Y)

Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.

Alexander Teumer (A)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
ORCID: 0000-0002-8309-094X

Anbupalam Thalamuthu (A)

Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia.

Julian N Trollor (JN)

Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia.
Department of Developmental Disability Neuropsychiatry, UNSW, Sydney, New South Wales, Australia.
ORCID: 0000-0002-7685-2977

Maria C Valdés Hernández (MC)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Row Fogo Centre for Research into Ageing and the Brain, University of Edinburgh, Edinburgh, UK.

Meike W Vernooij (MW)

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Uwe Völker (U)

Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.

Katharina Wittfeld (K)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
ORCID: 0000-0003-4383-5043

Tien Yin Wong (TY)

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Tsinghua Medicine, Tsinghua University, Beijing, China.

Margaret J Wright (MJ)

Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
ORCID: 0000-0001-7133-4970

Junyi Zhang (J)

Department of Neurology, Peking Union Medical College Hospital, Beijing, China.

Wanting Zhao (W)

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
The Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.

Yi-Cheng Zhu (YC)

Department of Neurology, Peking Union Medical College Hospital, Beijing, China.

Helena Schmidt (H)

Institute for Molecular Biology & Biochemistry, Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Graz, Austria.
ORCID: 0000-0001-9773-9992

Perminder S Sachdev (PS)

Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia.
Neuropsychiatric Institute, the Prince of Wales Hospital, Sydney, New South Wales, Australia.
ORCID: 0000-0002-9595-3220

Wei Wen (W)

Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia.
ORCID: 0000-0003-2753-3870

Kazumichi Yoshida (K)

Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Anne Joutel (A)

Institut de Psychiatrie et Neurosciences de Paris, Université Paris Cité, Inserm, France.

Claudia L Satizabal (CL)

Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
The Framingham Heart Study, Framingham, MA, USA.
Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA.
Department of Population Health Sciences, UT Health San Antonio, San Antonio, TX, USA.

Ralph L Sacco (RL)

Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Evelyn F. McKnight Brain Institute, Department of Neurology, University of Miami, Miami, FL, USA.
Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
Department of Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Department of Neurosurgery, Miller School of Medicine, University of Miami, Miami, FL, USA.

Guillaume Bourque (G)

Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montreal, Quebec, Canada.
Canadian Centre for Computational Genomics, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0002-3933-9656

Mark Lathrop (M)

Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montreal, Quebec, Canada.

Tomas Paus (T)

University of Montreal, Faculty of Medicine, Departments of Psychiatry and Neuroscience, Montreal, Quebec, Canada.
Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
Centre Hospitalier Universitaire Sainte Justine, Montreal, Quebec, Canada.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
ORCID: 0000-0003-1495-9338

Israel Fernandez-Cadenas (I)

Stroke Pharmacogenomics and Genetics Group, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.
Stroke Pharmacogenomics and Genetics Group, Fundació per la Docència i la Recerca Mutua Terrassa, Terrassa, Spain.

Qiong Yang (Q)

The Framingham Heart Study, Framingham, MA, USA.
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Bernard Mazoyer (B)

Groupe d'Imagerie Neurofonctionelle - Institut des maladies neurodégénératives (GIN-IMN), UMR 5293, University of Bordeaux, CNRS, CEA, Bordeaux, France.
Bordeaux University Hospital, Bordeaux, France.
ORCID: 0000-0003-0970-2837

Philippe Boutinaud (P)

Fealinx, Lyon, France.

Yukinori Okada (Y)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.
Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan.
Department of Genome Informatics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
ORCID: 0000-0002-0311-8472

Hans J Grabe (HJ)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
ORCID: 0000-0003-3684-4208

Karen A Mather (KA)

Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia.
Neuroscience Research Australia, Sydney, New South Wales, Australia.
ORCID: 0000-0003-4143-8941

Reinhold Schmidt (R)

Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.

Marc Joliot (M)

Groupe d'Imagerie Neurofonctionelle - Institut des maladies neurodégénératives (GIN-IMN), UMR 5293, University of Bordeaux, CNRS, CEA, Bordeaux, France.
ORCID: 0000-0001-7792-308X

M Arfan Ikram (MA)

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0003-0372-8585

Fumihiko Matsuda (F)

Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Christophe Tzourio (C)

Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.
Department of Medical Informatics, Bordeaux University Hospital, Bordeaux, France.

Joanna M Wardlaw (JM)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
UK Dementia Research Institute Centre at the University of Edinburgh, Edinburgh, UK.
Row Fogo Centre for Research into Ageing and the Brain, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-9812-6642

Sudha Seshadri (S)

Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
The Framingham Heart Study, Framingham, MA, USA.
Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA.
Department of Population Health Sciences, UT Health San Antonio, San Antonio, TX, USA.
ORCID: 0000-0001-6135-2622

Hieab H H Adams (HHH)

Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, the Netherlands. h.adams@erasmusmc.nl.
Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands. h.adams@erasmusmc.nl.
Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile. h.adams@erasmusmc.nl.
ORCID: 0000-0003-3687-2508

Stéphanie Debette (S)

Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France. stephanie.debette@u-bordeaux.fr.
Department of Neurology, Institute of Neurodegenerative Diseases, Bordeaux University Hospital, Bordeaux, France. stephanie.debette@u-bordeaux.fr.
ORCID: 0000-0001-8675-7968

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genomics of perivascular space burden unravels...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Genomics of perivascular space burden unravels...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genomics of perivascular space burden unravels...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Maladies des petits vaisseaux cérébraux › Genomics of perivascular space burden unravels...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Genomics of perivascular space burden unravels...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Genomics of perivascular space burden unravels...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Genomics of perivascular space burden unravels...