Acute vulvar ulcer as a possible adverse event of gene-based COVID-19 vaccines: A review of 14 cases.
COVID-19 vaccine
adolescent
adverse event
mRNA vaccines
vulvar ulcer
Journal
The journal of obstetrics and gynaecology research
ISSN: 1447-0756
Titre abrégé: J Obstet Gynaecol Res
Pays: Australia
ID NLM: 9612761
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
29
12
2022
accepted:
17
03
2023
medline:
5
7
2023
pubmed:
19
4
2023
entrez:
18
4
2023
Statut:
ppublish
Résumé
To evaluate whether an acute vulvar ulcer that developed after the COVID-19 vaccine administration is an adverse effect of the vaccine. This is a descriptive study of two cases that we observed in addition to cases that have been reported in the literature. We searched for case reports in the PubMed. The consistency of clinical manifestations among cases and the association between ulceration and vaccination were assessed. Fourteen female patients were identified, including 12 patients from 8 literatures published in 2021 and 2022 and 2 patients from our cases. Of the 14 patients, 11 had received the BNT162b2 vaccine, 2 had received the ChAdOx1 nCoV-19 vaccine, and one had received the mRNA-1273 vaccine. The patient's ages were 16.9 ± 5.0 (mean ± SD) years. Postvaccination, the disease progressed in the following sequence (time interval from vaccination): fever and other systemic inflammatory reactions (0.9 ± 0.4 days), development of vulvar ulcers (2.4 ± 1.2 days), and resolution of the ulcer (16.9 ± 7.4 days). The ulcers eventually healed in all cases, except one where the prognosis was not noted. For two-dose vaccine recipients, more patients developed the ulcer after the full vaccination (the second or third doses) compared with after the first dose: n = 10 and n = 2, respectively. The acute vulvar ulcer was closely associated with COVID-19 vaccination in terms of temporality and vaccine doses, supporting the notion that a vulvar ulcer is an adverse event of the COVID-19 vaccines.
Substances chimiques
2019-nCoV Vaccine mRNA-1273
EPK39PL4R4
BNT162 Vaccine
0
ChAdOx1 nCoV-19
B5S3K2V0G8
COVID-19 Vaccines
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1846-1853Informations de copyright
© 2023 Japan Society of Obstetrics and Gynecology.
Références
Farhi D, Wendling J, Molinari E, Raynal J, Carcelain G, Morand P, et al. Non-sexually related acute genital ulcers in 13 pubertal girls: a clinical and microbiological study. Arch Dermatol. 2009;145(1):38-45.
Huppert JS. Lipschutz ulcers: evaluation and management of acute genital ulcers in women. Dermatol Ther. 2010;23(5):533-40.
Gonzalez-Romero N, Morillo Montanes V, Vicente Sanchez I, Garcia Garcia M. Lipschutz ulcers after the AstraZeneca COVID-19 vaccine. Actas Dermosifiliogr (Engl Ed). 2021;113:S29.
Wojcicki AV, O'Flynn O'Brien KL. Vulvar aphthous ulcer in an adolescent after Pfizer-BioNTech (BNT162b2) COVID-19 vaccination. J Pediatr Adolesc Gynecol. 2022;35(2):167-70.
Drucker A, Corrao K, Gandy M. Vulvar aphthous ulcer following Pfizer-BioNTech COVID-19 vaccine - a case report. J Pediatr Adolesc Gynecol. 2022;35(2):165-6.
Popatia S, Chiu YE. Vulvar aphthous ulcer after COVID-19 vaccination. Pediatr Dermatol. 2022;39(1):153-4.
Wijaya M, Zhao C, Forward E, Nguyen Y, Kherlopian A, Jollow D, et al. Acute vulvar aphthous ulceration after COVID-19 vaccination: 3 cases. J Low Genit Tract Dis. 2022;26(2):186-8.
Hsu T, Sink JR, Alaniz VI, Zheng L, Mancini AJ. Acute genital ulceration after severe acute respiratory syndrome coronavirus 2 vaccination and infection. J Pediatr. 2022;246:271-3.
Falkenhain-Lopez D, Agud-Dios M, Ortiz-Romero PL, Sanchez-Velazquez A. COVID-19-related acute genital ulcers. J Eur Acad Dermatol Venereol. 2020;34(11):e655-e6.
Christl J, Alaniz VI, Appiah L, Buyers E, Scott S, Huguelet PS. Vulvar aphthous ulcer in an adolescent with COVID-19. J Pediatr Adolesc Gynecol. 2021;34(3):418-20.
Krapf JM, Casey RK, Goldstein AT. Reactive non-sexually related acute genital ulcers associated with COVID-19. BMJ Case Rep. 2021;14(5):e242653.
Alberelli MC, Panariello A, Olivi M, Borghi A, Zedde P, Corazza M. Ulcus vulvae acutum and SARS-CoV-2: an aetiological role? J Eur Acad Dermatol Venereol. 2021;35(10):e647-e9.
Jacyntho CMA, Lacerda MI, Carvalho MSR, Ramos M, Vieira-Baptista P, Bandeira S. COVID-19 related acute genital ulcer: a case report. Einstein (Sao Paulo). 2022;20:eRC6541.
Morais ML, Moura M, Moreira A. Lipschutz's ulcers in an adolescent with SARS-CoV2 infection. Clin Case Rep. 2022;10(10):e6503.
Schmitt TM, Devries J, Ohns MJ. Lipschutz ulcers in an adolescent after Sars-CoV-2 infection. J Pediatr Health Care. 2022;37:63-6.
Kewan T, Flores M, Mushtaq K, Alwakeel M, Burton R, Campbell J, et al. Characteristics and outcomes of adverse events after COVID-19 vaccination. J Am Coll Emerg. 2021;2(5):e12565.
Tammaro A, Kulakowska KA, Cantisani C, Parisella FR, Scarabello A, Adebanjo GAR. Female genital mucosal lesions associated with COVID-19 vaccination: a brief review of the literature. J Eur Acad Dermatol Venereol. 2022;37:e143-6.
Huppert J. Adolescents with vulvar ulcers: COVID-19 disease, COVID-19 vaccines, and the value of case reports. J Pediatr Adolesc Gynecol. 2022;35(2):109-11.
Scott SM, Alaniz V, Appiah L, Buyers E, Holton C, Huguelet P. Vulvar aphthous ulcers in an adolescent after coronavirus disease 2019 (COVID-19) vaccination. Obstet Gynecol. 2022;140:514-7.
Salusti-Simpson M, Porter H, Fischer A. Acute vulvar ulcers and the COVID-19 booster vaccine. JAAD Case Rep. 2022;26:82-4.
Huppert JS, Gerber MA, Deitch HR, Mortensen JE, Staat MA, Adams Hillard PJ. Vulvar ulcers in young females: a manifestation of aphthosis. J Pediatr Adolesc Gynecol. 2006;19(3):195-204.
Vismara SA, Lava SAG, Kottanattu L, Simonetti GD, Zgraggen L, Clericetti CM, et al. Lipschutz's acute vulvar ulcer: a systematic review. Eur J Pediatr. 2020;179(10):1559-67.
Sadoghi B, Stary G, Wolf P, Komericki P. Ulcus vulvae acutum Lipschutz: a systematic literature review and a diagnostic and therapeutic algorithm. J Eur Acad Dermatol Venereol. 2020;34(7):1432-9.
Brambilla I, Moiraghi A, Guarracino C, Pistone C, Tondina E, Riccipetitoni G, et al. Recurrent reactive non-sexually related acute genital ulcers: a risk factor for Behcet's disease? Acta Biomed. 2022;93(S3):e2022196.
Watad A, De Marco G, Mahajna H, Druyan A, Eltity M, Hijazi N, et al. Immune-mediated disease flares or new-onset disease in 27 subjects following mRNA/DNA SARS-CoV-2 vaccination. Vaccines (Basel). 2021;9(5):435.
Marcelino J, Vieira J, Ferreira F, Didenko I, Reis R, Silva R, et al. Stevens-Johnson syndrome related with Comirnaty® coronavirus disease 2019 vaccine. Asia Pac Allergy. 2022;12(3):e30.
Allstaff S, Grzybek A, Nellore V, et al. P01 severe acute vulval ulceration associated with COVID-19 infection in a sexually active dual COVID-vaccinated young person: a case report. Sex Transm Infect. 2022;98(Suppl 1):A25-A.
Aboul Naga SH, Hassan LM, El Zanaty RT, Refaat M, Amin RH, Ragab G, et al. Behçet uveitis: current practice and future perspectives. Front Med (Lausanne). 2022;9:968345.
Holms RD, Ataullakhanov RI. Ezrin peptide therapy from HIV to COVID: inhibition of inflammation and amplification of adaptive anti-viral immunity. Int J Mol Sci. 2021;22(21):11688.
Mungmunpuntipantip R, Wiwanitkit V. Vulvar aphthous ulcer and COVID-19 mRNA vaccination. J Pediatr Adolesc Gynecol. 2022;35(3):410.