Nitric Oxide Precursors and Dimethylarginines as Risk Markers for Accelerated Measured GFR Decline in the General Population.
ADMA
SDMA
chronic kidney disease
glomerular filtration rate
nitric oxide
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
15
08
2022
revised:
02
12
2022
accepted:
09
01
2023
medline:
19
4
2023
entrez:
18
4
2023
pubmed:
19
4
2023
Statut:
epublish
Résumé
Nitric oxide (NO) deficiency is associated with endothelial dysfunction, hypertension, atherosclerosis, and chronic kidney disease (CKD). Reduced NO bioavailability is hypothesized to play a vital role in kidney function impairment and CKD. We investigated the association of serum levels of endogenous inhibitors of NO, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), and precursors of NO, arginine, citrulline, and ornithine, with a decline in glomerular filtration rate (GFR) and new-onset CKD. In a prospective cohort study of 1407 healthy, middle-aged participants of Northern European origin in the Renal Iohexol Clearance Survey (RENIS), GFR was measured repeatedly with iohexol clearance during a median follow-up time of 11 years. GFR decline rates were analyzed using a linear mixed model, new-onset CKD (GFR < 60 ml/min per 1.73 m Higher SDMA was associated with slower annual GFR decline. Higher levels of citrulline and ornithine were associated with accelerated GFR decline (odds ratio [OR], 1.43; 95% confidence interval [CI] 1.16-1.76 per SD higher citrulline and OR 1.23; 95% CI 1.01 to 1.49 per SD higher ornithine). Higher citrulline was associated with new-onset CKD, with a hazard ratio of 1.33 (95% CI 1.07-1.66) per SD higher citrulline. Associations between NO precursors and the outcomes suggest that NO metabolism plays a significant role in the pathogenesis of age-related GFR decline and the development of CKD in middle-aged people.
Identifiants
pubmed: 37069987
doi: 10.1016/j.ekir.2023.01.015
pii: S2468-0249(23)00016-5
pmc: PMC10105054
doi:
Types de publication
Journal Article
Langues
eng
Pagination
818-826Informations de copyright
© 2023 International Society of Nephrology. Published by Elsevier Inc.
Références
J Am Soc Nephrol. 2005 Aug;16(8):2456-61
pubmed: 15930091
Kidney Int. 2016 Aug;90(2):404-410
pubmed: 27188503
J Am Soc Nephrol. 2017 Oct;28(10):2838-2844
pubmed: 28790143
N Engl J Med. 2004 Sep 23;351(13):1296-305
pubmed: 15385656
Biomedicines. 2020 Jul 17;8(7):
pubmed: 32708997
Circ J. 2013;77(1):181-7
pubmed: 23001044
Prev Med. 2011 Oct;53(4-5):274-7
pubmed: 21827781
Adv Chronic Kidney Dis. 2016 Jan;23(1):19-28
pubmed: 26709059
Am J Kidney Dis. 2016 Jun;67(6):841-50
pubmed: 26744126
Lancet. 2001 Dec 22-29;358(9299):2127-8
pubmed: 11784629
Amino Acids. 2006 May;30(3):225-32
pubmed: 16680555
Nat Rev Nephrol. 2011 May;7(5):275-85
pubmed: 21445101
Kidney Int. 2010 Dec;78(12):1305-11
pubmed: 20844470
J Am Soc Nephrol. 2006 Apr;17(4):1128-34
pubmed: 16481412
Atherosclerosis. 2011 Sep;218(1):220-5
pubmed: 21632053
J Am Soc Nephrol. 2009 Nov;20(11):2305-13
pubmed: 19833901
Am J Nephrol. 2015;41(1):7-15
pubmed: 25612475
BMC Nephrol. 2014 Mar 14;15:45
pubmed: 24628838
Clin Chim Acta. 2010 Oct 9;411(19-20):1412-20
pubmed: 20598675
Am J Physiol Renal Physiol. 2008 Jan;294(1):F1-9
pubmed: 17928410
Nat Clin Pract Nephrol. 2006 Apr;2(4):209-20
pubmed: 16932427
Nephrol Dial Transplant. 2023 Jan 23;38(1):106-118
pubmed: 36002032
J Am Soc Nephrol. 2005 Aug;16(8):2449-55
pubmed: 15944335
Clin Chim Acta. 2003 Oct;336(1-2):1-12
pubmed: 14500028
Int J Mol Sci. 2012;13(9):11288-11311
pubmed: 23109853
Biochem Biophys Res Commun. 2000 Sep 7;275(3):715-9
pubmed: 10973788
J Am Soc Nephrol. 2011 May;22(5):927-37
pubmed: 21454717
Lancet. 2020 Feb 29;395(10225):709-733
pubmed: 32061315
Int J Epidemiol. 2012 Aug;41(4):961-7
pubmed: 21422063
Clin Kidney J. 2016 Oct;9(5):700-4
pubmed: 27679716
Metabolomics. 2021 Jan 11;17(1):9
pubmed: 33428023
Heart. 2001 Mar;85(3):342-50
pubmed: 11179281
J Am Soc Nephrol. 2022 Oct;33(10):1891-1902
pubmed: 35977806
Lancet. 2012 Jan 14;379(9811):165-80
pubmed: 21840587
J Am Soc Nephrol. 2013 Jul;24(8):1330-8
pubmed: 23687356
Nephrol Dial Transplant. 2006 Sep;21(9):2446-51
pubmed: 16766542
EJIFCC. 2001 Jul 22;13(2):48-52
pubmed: 30429722
Kidney Int. 2000 Sep;58(3):1261-6
pubmed: 10972689
J Hypertens. 2012 Mar;30(3):497-504
pubmed: 22278141
Atheroscler Suppl. 2003 Dec;4(4):23-8
pubmed: 14664899
Clin Physiol. 1983 Aug;3(4):297-305
pubmed: 6684515
Clin J Am Soc Nephrol. 2017 Apr 3;12(4):624-634
pubmed: 28153935
Lancet. 1992 Mar 7;339(8793):572-5
pubmed: 1347093
Lancet. 2001 Dec 22-29;358(9299):2113-7
pubmed: 11784625
Nephrol Dial Transplant. 2021 Sep 27;36(10):1882-1892
pubmed: 33068410
Atherosclerosis. 2008 Dec;201(2):398-406
pubmed: 18405901
PLoS One. 2021 May 14;16(5):e0251308
pubmed: 33989340
Kidney Int. 2008 Aug;74(4):505-12
pubmed: 18496511
Hypertension. 2017 Apr;69(4):651-659
pubmed: 28223468
J Am Soc Nephrol. 2019 Sep;30(9):1746-1755
pubmed: 31292199