Development of the gut microbiota in the first 14 years of life and its relations to internalizing and externalizing difficulties and social anxiety during puberty.
Externalizing behavior
Faecalibacterium
Gut microbiota development
Prevotella 9
Puberty
Social anxiety
Journal
European child & adolescent psychiatry
ISSN: 1435-165X
Titre abrégé: Eur Child Adolesc Psychiatry
Pays: Germany
ID NLM: 9212296
Informations de publication
Date de publication:
18 Apr 2023
18 Apr 2023
Historique:
received:
13
01
2023
accepted:
03
04
2023
entrez:
18
4
2023
pubmed:
19
4
2023
medline:
19
4
2023
Statut:
aheadofprint
Résumé
Relations between the gut microbiota and host mental health have been suggested by a growing number of case-control and cross-sectional studies, while supporting evidence is limited in large community samples followed during an extended period. Therefore, the current preregistered study ( https://osf.io/8ymav , September 7, 2022) described child gut microbiota development in the first 14 years of life and explored its relations to internalizing and externalizing difficulties and social anxiety in puberty, a period of high relevance for the development of mental health problems. Fecal microbiota composition was analysed by 16S ribosomal RNA gene amplicon sequencing in a total of 1003 samples from 193 children. Through a clustering method, four distinct microbial clusters were newly identified in puberty. Most children within three of these clusters remained in the same clusters from the age of 12 to 14 years, suggesting stability in microbial development and transition during this period. These three clusters were compositionally similar to enterotypes (i.e., a robust classification of the gut microbiota based on its composition across different populations) enriched in Bacteroides, Prevotella, and Ruminococcus, respectively. Two Prevotella 9-predominated clusters, including one reported by us earlier in middle childhood and the other one in puberty, were associated with more externalizing behavior at age 14. One Faecalibacterium-depleted pubertal cluster was related to more social anxiety at age 14. This finding was confirmed by a negative cross-sectional relation between Faecalibacterium and social anxiety in the 14-year-olds. The findings of this study continue to map gut microbiota development in a relatively large community sample followed from birth onwards, importantly extending our knowledge to puberty. Results indicate that Prevotella 9 and Faecalibacterium may be relevant microbial taxa in relation to externalizing behavior and social anxiety, respectively. These correlational findings need validations from other similar cohort studies, as well as well-designed mechanistic pre-clinical investigations before inferring cause and effect.
Identifiants
pubmed: 37071196
doi: 10.1007/s00787-023-02205-9
pii: 10.1007/s00787-023-02205-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : China Scholarship Council
ID : No. 201806350255
Organisme : Eat2beNICE project of European Union's Horizon 2020 research and innovation program
ID : No. 728018
Organisme : Eat2beNICE project of European Union's Horizon 2020 research and innovation program
ID : No. 728018
Organisme : Eat2beNICE project of European Union's Horizon 2020 research and innovation program
ID : No. 728018
Organisme : Netherlands Organization for Scientific Research VIDI
ID : 575-25-009
Organisme : Netherlands Organization for Scientific Research VICI
ID : 016.Vici.185.038
Informations de copyright
© 2023. The Author(s).
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