Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia.
dorsal root ganglia
fibromyalgia
neuroimmune
neutrophils
pain
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
25 04 2023
25 04 2023
Historique:
medline:
20
4
2023
entrez:
18
4
2023
pubmed:
19
4
2023
Statut:
ppublish
Résumé
Fibromyalgia is a debilitating widespread chronic pain syndrome that occurs in 2 to 4% of the population. The prevailing view that fibromyalgia results from central nervous system dysfunction has recently been challenged with data showing changes in peripheral nervous system activity. Using a mouse model of chronic widespread pain through hyperalgesic priming of muscle, we show that neutrophils invade sensory ganglia and confer mechanical hypersensitivity on recipient mice, while adoptive transfer of immunoglobulin, serum, lymphocytes, or monocytes has no effect on pain behavior. Neutrophil depletion abolishes the establishment of chronic widespread pain in mice. Neutrophils from patients with fibromyalgia also confer pain on mice. A link between neutrophil-derived mediators and peripheral nerve sensitization is already established. Our observations suggest approaches for targeting fibromyalgia pain via mechanisms that cause altered neutrophil activity and interactions with sensory neurons.
Identifiants
pubmed: 37071676
doi: 10.1073/pnas.2211631120
pmc: PMC10151464
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2211631120Subventions
Organisme : Versus Arthritis
ID : 21734
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 21950
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 20886
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 200183/Z/15/Z
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 22911
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N010973/1
Pays : United Kingdom
Références
Exp Neurol. 2008 Apr;210(2):286-94
pubmed: 18201702
J Neurophysiol. 1991 Jul;66(1):228-46
pubmed: 1919669
Clin Immunol Immunopathol. 1998 Jun;87(3):304-8
pubmed: 9646841
Pain. 1998 Sep;77(3):315-322
pubmed: 9808357
Blood. 2010 Jul 29;116(4):625-7
pubmed: 20410504
Neuroscience. 2000;101(3):745-57
pubmed: 11113323
Pain. 2003 Aug;104(3):567-577
pubmed: 12927629
Brain Behav Immun. 2009 May;23(4):548-57
pubmed: 19233260
Brain. 2013 Jun;136(Pt 6):1857-67
pubmed: 23474848
Rheumatology (Oxford). 2020 Oct 1;59(10):3042-3049
pubmed: 32206792
J Neurosci. 2004 Oct 20;24(42):9405-13
pubmed: 15496676
Pain. 2019 Sep;160(9):2050-2062
pubmed: 31095099
Eur J Pain. 2011 Jan;15(1):61-9
pubmed: 20889359
PLoS One. 2018 Sep 13;13(9):e0203755
pubmed: 30212526
J Pain. 2007 May;8(5):422-9
pubmed: 17293165
Ann Clin Biochem. 2014 Sep;51(Pt 5):576-81
pubmed: 24106344
J Leukoc Biol. 2008 Apr;83(4):824-32
pubmed: 18203872
J Neuroimmunol. 2007 Mar;184(1-2):164-71
pubmed: 17275921
Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug;358(2):264-9
pubmed: 9750013
Brain. 2018 Apr 1;141(4):1028-1039
pubmed: 29394316
Ann N Y Acad Sci. 2010 Jun;1198:153-8
pubmed: 20536929
Sci Transl Med. 2022 May 11;14(644):eabj9954
pubmed: 35544595
Rheumatology (Oxford). 2001 Jul;40(7):743-9
pubmed: 11477278
Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):547-52
pubmed: 22203955
Cancer. 2004 Jan 15;100(2):228-37
pubmed: 14716755
Neuroimmunomodulation. 2012;19(6):343-51
pubmed: 22986514
Arthritis Rheum. 1991 Mar;34(3):270-5
pubmed: 2003853
Neurobiol Pain. 2020 Jan 21;7:100043
pubmed: 32510006
Neurobiol Pain. 2018 Oct 19;5:100024
pubmed: 31194015
Pain. 2017 Jun;158(6):1046-1052
pubmed: 28195854
Intern Med J. 2021 Dec;51(12):1990-1998
pubmed: 34139045
Pain. 2003 Sep;105(1-2):143-50
pubmed: 14499430
Am J Pathol. 1988 Mar;130(3):605-15
pubmed: 3348361
Sci Transl Med. 2011 Jul 6;3(90):90ra60
pubmed: 21734176
Pain. 2016 Dec;157(12):2722-2730
pubmed: 27841839
Brain Res. 2011 Aug 8;1405:95-108
pubmed: 21741621
Ann Neurol. 2014 Feb;75(2):196-208
pubmed: 24243538
Arthritis Res Ther. 2013;15(6):222
pubmed: 24314231
J Neuroinflammation. 2020 Feb 4;17(1):49
pubmed: 32019585
J Leukoc Biol. 2013 Oct;94(4):595-601
pubmed: 23625199
Clin Rheumatol. 2017 Aug;36(8):1885-1889
pubmed: 28466420
Science. 1984 Aug 17;225(4663):743-5
pubmed: 6087456
Gastroenterology. 2004 Apr;126(4):1082-9
pubmed: 15057747
Nature. 2014 Jun 5;510(7503):157-61
pubmed: 24759321
PLoS Pathog. 2009 Apr;5(4):e1000362
pubmed: 19343210
Muscle Nerve. 2001 Jan;24(1):37-46
pubmed: 11150964
Nat Med. 1999 Sep;5(9):1057-61
pubmed: 10470085
Neuron. 2022 Feb 16;110(4):613-626.e9
pubmed: 34921782
Nat Med. 2015 Sep;21(9):1071-5
pubmed: 26236990
Pain. 2008 Jun;136(3):331-339
pubmed: 17764841
Pain. 2006 Nov;125(1-2):180-7
pubmed: 16996691
Mol Pain. 2018 Jan-Dec;14:1744806918817975
pubmed: 30453826
Nat Med. 2015 May;21(5):518-23
pubmed: 25915831
Semin Immunol. 2016 Apr;28(2):137-45
pubmed: 27021499
J Neuroimmunol. 2007 Aug;188(1-2):159-66
pubmed: 17602758
Pain. 2017 Nov;158(11):2243-2258
pubmed: 28837503
J Neurosci. 1985 Nov;5(11):3025-9
pubmed: 2997412
Blood. 2016 Nov 10;128(19):2327-2337
pubmed: 27609642
Int J Mol Sci. 2017 Nov 01;18(11):
pubmed: 29104252
Clin Exp Rheumatol. 2007 Mar-Apr;25(2):225-30
pubmed: 17543146
Neuron. 2017 Feb 22;93(4):822-839.e6
pubmed: 28162807
Mol Pain. 2006 Feb 17;2:7
pubmed: 16503978
J Clin Invest. 2021 Jul 1;131(13):
pubmed: 34196305
PLoS One. 2013 Sep 04;8(9):e74524
pubmed: 24023948
Blood. 2016 May 5;127(18):2173-81
pubmed: 27002116
Prostaglandins. 1985 Nov;30(5):791-7
pubmed: 3001832
Nat Med. 1996 Nov;2(11):1259-62
pubmed: 8898757
Sci Rep. 2019 Aug 19;9(1):12003
pubmed: 31427756
J Neurophysiol. 1990 May;63(5):966-70
pubmed: 2162922