A nanomedicine based on stoichiometric coordination of camptothecin and organoplatinum (II) for synergistic antitumor therapy.

Mice Animals Humans Female Camptothecin / pharmacology Nanomedicine Hydrogen Peroxide Cell Line, Tumor Polymers Disease Models, Animal Glutathione Breast Neoplasms / drug therapy
Camptothecin Combination therapy Nanomedicine Organoplatinum Stoichiometric

Journal

Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144

Informations de publication

Date de publication:
01 07 2023
Historique:
received: 13 01 2023
revised: 30 03 2023
accepted: 07 04 2023
medline: 29 5 2023
pubmed: 19 4 2023
entrez: 18 4 2023
Statut: ppublish

Résumé

Precise combination therapy, involving multiple chemotherapeutics with pharmacologically synergistic antitumor effects, is a promising approach to address the challenge of monotherapy with insufficient activity towards their targets of interest. We employed Pt←pyridine coordination-driven assembly to construct a stoichiometric coordination complex of camptothecin and organoplatinum (II) (Pt-CPT). The Pt-CPT complex exhibited a remarkable synergistic effect toward several tumor cell lines, which is equal to the optimal synergistic effect of (PEt

Identifiants

DOI: 10.1016/j.actbio.2023.04.010 PMID: 37072068
pubmed: 37072068
pii: S1742-7061(23)00202-7
doi: 10.1016/j.actbio.2023.04.010
pii:
doi:

Substances chimiques

Camptothecin XT3Z54Z28A
Hydrogen Peroxide BBX060AN9V
Polymers 0
Glutathione GAN16C9B8O

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

553-562

Informations de copyright

Copyright © 2023 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Chao Li (C)

Department of Orthopaedic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450052 PR China.

Yu Chen (Y)

School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052 PR China; Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052 PR China.

Yong Gao (Y)

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058 PR China.

Xin Wang (X)

Department of Orthopaedic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450052 PR China.

Jiaqiang Wang (J)

Department of Orthopaedic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450052 PR China.

Peng Zhang (P)

Department of Orthopaedic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450052 PR China.

Xiaobo Hu (X)

Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052 PR China; Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052 PR China.

Lei Li (L)

Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052 PR China; Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052 PR China.

Weijun Tong (W)

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058 PR China. Electronic address: tongwj@zju.edu.cn.

Zhigang Ren (Z)

Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052 PR China; Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052 PR China. Electronic address: fccrenzg@zzu.edu.cn.

Weitao Yao (W)

Department of Orthopaedic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450052 PR China. Electronic address: ywtwhm@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A nanomedicine based on stoichiometric...
questionsmedicales.fr › Eucaryotes › Animaux › A nanomedicine based on stoichiometric...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A nanomedicine based on stoichiometric...
questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Camptothécine › A nanomedicine based on stoichiometric...
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