Airway obstruction in respiratory viral infections due to impaired mucociliary clearance.
airway obstruction
bronchial tree
mathematical modeling
mucus motion
viral infection
Journal
International journal for numerical methods in biomedical engineering
ISSN: 2040-7947
Titre abrégé: Int J Numer Method Biomed Eng
Pays: England
ID NLM: 101530293
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
14
03
2023
received:
25
10
2022
accepted:
02
04
2023
medline:
30
11
2023
pubmed:
19
4
2023
entrez:
19
04
2023
Statut:
ppublish
Résumé
Respiratory viral infections, such as SARS-CoV-2 or influenza, can lead to impaired mucociliary clearance in the bronchial tree due to increased mucus viscosity and its hyper-secretion. We develop in this work a mathematical model to study the interplay between viral infection and mucus motion. The results of numerical simulations show that infection progression can be characterized by three main stages. At the first stage, infection spreads through the most part of mucus producing airways (about 90% of the length) without significant changes in mucus velocity and thickness layer. During the second stage, when it passes through the remaining generations, mucus viscosity increases, its velocity drops down, and it forms a plug. At the last stage, the thickness of the mucus layer gradually increases because mucus is still produced but not removed by the flow. After some time, the thickness of the mucus layer in the small airways becomes comparable with their diameter leading to their complete obstruction.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3707Subventions
Organisme : RUDN University Scientific Projects Grant System
Informations de copyright
© 2023 John Wiley & Sons Ltd.
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