Functional Synthetic Biology.
Collaboration
Design
Engineering
Reproducibility
Synthetic Biology
Journal
Synthetic biology (Oxford, England)
ISSN: 2397-7000
Titre abrégé: Synth Biol (Oxf)
Pays: England
ID NLM: 101728857
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
06
2022
revised:
17
02
2023
accepted:
04
04
2023
medline:
19
4
2023
pubmed:
19
4
2023
entrez:
19
04
2023
Statut:
epublish
Résumé
Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current paradigms in the field entangle sequence and functionality in a manner that makes abstraction difficult, reduces engineering flexibility and impairs predictability and design reuse. Functional Synthetic Biology aims to overcome these impediments by focusing the design of biological systems on function, rather than on sequence. This reorientation will decouple the engineering of biological devices from the specifics of how those devices are put to use, requiring both conceptual and organizational change, as well as supporting software tooling. Realizing this vision of Functional Synthetic Biology will allow more flexibility in how devices are used, more opportunity for reuse of devices and data, improvements in predictability and reductions in technical risk and cost.
Identifiants
pubmed: 37073284
doi: 10.1093/synbio/ysad006
pii: ysad006
pmc: PMC10105873
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
ysad006Informations de copyright
© The Author(s) 2023. Published by Oxford University Press.
Déclaration de conflit d'intérêts
No competing interest is declared.
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