Illuminating the Chemical Space of Untargeted Proteins.

Humans Ligands Proteins / chemistry Polypharmacology

Journal

Journal of chemical information and modeling
ISSN: 1549-960X
Titre abrégé: J Chem Inf Model
Pays: United States
ID NLM: 101230060

Informations de publication

Date de publication:
08 05 2023
Historique:
medline: 9 5 2023
pubmed: 19 4 2023
entrez: 19 04 2023
Statut: ppublish

Résumé

According to the Illuminating the Druggable Genome (IDG) initiative, 90% of the proteins encoded by the human genome still lack an identified active ligand, that is, a small molecule with biologically relevant binding potency or functional activity in an

Identifiants

DOI: 10.1021/acs.jcim.2c01364 PMID: 37074232
pubmed: 37074232
doi: 10.1021/acs.jcim.2c01364
doi:

Substances chimiques

Ligands 0
Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2689-2698

Auteurs

Maria J Falaguera (MJ)

Research Group on Systems Pharmacology, Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical Research Institute, Parc de Recerca Biomedica (PRBB), Doctor Aiguader 88, 08003 Barcelona, Catalonia, Spain.
Chemotargets SL, Parc Cientific de Barcelona, Baldiri Reixac 4, 08028 Barcelona, Catalonia, Spain.

Jordi Mestres (J)

Research Group on Systems Pharmacology, Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical Research Institute, Parc de Recerca Biomedica (PRBB), Doctor Aiguader 88, 08003 Barcelona, Catalonia, Spain.
Chemotargets SL, Parc Cientific de Barcelona, Baldiri Reixac 4, 08028 Barcelona, Catalonia, Spain.
ORCID: 0000-0002-5202-4501

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Illuminating the Chemical Space of Untargeted Proteins.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Illuminating the Chemical Space of Untargeted Proteins.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Illuminating the Chemical Space of Untargeted Proteins.
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Polypharmacologie › Illuminating the Chemical Space of Untargeted Proteins.