A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides.
ACE
ACE2
DX600
Gallium
PET
Radiopeptide
SARS-CoV-2
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
19 Apr 2023
19 Apr 2023
Historique:
received:
12
12
2022
accepted:
29
03
2023
medline:
19
4
2023
pubmed:
19
4
2023
entrez:
19
04
2023
Statut:
epublish
Résumé
The angiotensin converting enzyme-2 (ACE2)-entry receptor of SARS-CoV-2-and its homologue, the angiotensin-converting enzyme (ACE), play a pivotal role in maintaining cardiovascular homeostasis. Potential changes in ACE2 expression levels and dynamics after SARS-CoV-2 infection have been barely investigated. The aim of this study was to develop an ACE2-targeting imaging agent as a noninvasive imaging tool to determine ACE2 regulation. DOTA-DX600, NODAGA-DX600 and HBED-CC-DX600 were obtained through custom synthesis and labeled with gallium-67 (T The highest molar activity was obtained for [ This study demonstrated ACE2 selectivity for all radiopeptides. [
Identifiants
pubmed: 37074529
doi: 10.1186/s13550-023-00979-2
pii: 10.1186/s13550-023-00979-2
pmc: PMC10113987
doi:
Types de publication
Journal Article
Langues
eng
Pagination
32Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 4078P0_198274
Informations de copyright
© 2023. The Author(s).
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