Autonomic dysfunction is associated with the development of arterial stiffness: the Whitehall II cohort.
Arterial stiffness
Heart rate variability
Resting heart rate
Whitehall II cohort; Cardiovascular disease
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
04
11
2022
accepted:
23
02
2023
medline:
27
11
2023
pubmed:
19
4
2023
entrez:
19
04
2023
Statut:
ppublish
Résumé
This study aims to examine the association between baseline level and change of autonomic nervous function with subsequent development of arterial stiffness. Autonomic nervous function was assessed in 4901 participants of the Whitehall II occupational cohort by heart rate variability (HRV) indices and resting heart rate (rHR) three times between 1997 and 2009, while arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV) measured twice between 2007 and 2013. First, individual HRV/rHR levels and annual changes were estimated. Then, we modelled the development of PWV by HRV/rHR using linear mixed effect models. First, we adjusted for sex and ethnicity (model 1), and then for socioeconomic and lifestyle factors, various clinical measurements, and medications (model 2). A decrease in HRV and unchanged rHR was associated with subsequent higher levels of PWV, but the effect of a change in HRV was less pronounced at higher ages. A typical individual aged 65 years with a SDNN level of 30 ms and a 2% annual decrease in SDNN had 1.32 (0.95; 1.69) higher PWV compared to one with the same age and SDNN level but with a 1% annual decrease in SDNN. Further adjustment had no major effect on the results. People who experience a steeper decline in autonomic nervous function have higher levels of arterial stiffness. The association was stronger in younger people.
Identifiants
pubmed: 37074615
doi: 10.1007/s11357-023-00762-0
pii: 10.1007/s11357-023-00762-0
pmc: PMC10651635
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2443-2455Subventions
Organisme : Medical Research Council
ID : MR/R024227/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S011676/1
Pays : United Kingdom
Informations de copyright
© 2023. The Author(s), under exclusive licence to American Aging Association.
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