Expression and function of toll-like receptor 2 in vertebrate.

Animals Toll-Like Receptor 2 Pathogen-Associated Molecular Pattern Molecules Endothelial Cells / metabolism Toll-Like Receptors / metabolism Vertebrates / metabolism Immunity, Innate
Immunity Phylogenesis Toll-like receptor 2 Vertebrates

Journal

Acta histochemica
ISSN: 1618-0372
Titre abrégé: Acta Histochem
Pays: Germany
ID NLM: 0370320

Informations de publication

Date de publication:
Apr 2023
Historique:
received: 08 03 2023
revised: 13 04 2023
accepted: 13 04 2023
medline: 28 4 2023
pubmed: 20 4 2023
entrez: 19 04 2023
Statut: ppublish

Résumé

Toll-like receptors (TLRs) are essential for identifying and detecting pathogen-associated molecular patterns (PAMPs) produced by a variety of pathogens, including viruses and bacteria. Since TLR2 is the only TLR capable of creating functional heterodimers with more than two other TLR types, it is very important for vertebrate immunity. TLR2 not only broadens the variety of PAMPs that it can recognize but has also the potential to diversify the subsequent signaling cascades. TLR2 is ubiquitous, which is consistent with the wide variety of tasks and functions it serves. Immune cells, endothelial cells, and epithelial cells have all been found to express TLR2. This review aims to gather currently available information about the preservation of this intriguing immunological molecule in the phylum of vertebrates.

Identifiants

DOI: 10.1016/j.acthis.2023.152028 PMID: 37075649
pubmed: 37075649
pii: S0065-1281(23)00034-X
doi: 10.1016/j.acthis.2023.152028
pii:
doi:

Substances chimiques

Toll-Like Receptor 2 0
Pathogen-Associated Molecular Pattern Molecules 0
Toll-Like Receptors 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

152028

Informations de copyright

Copyright © 2023 Elsevier GmbH. All rights reserved.

Auteurs

Simona Pergolizzi (S)

Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, 98166 Messina, Italy.

Angelo Fumia (A)

Department of Clinical and Experimental Medicine, University of Messina, Padiglione C, A. O. U. Policlinico "G. Martino", 98124 Messina, Italy.

Roberta D'Angelo (R)

Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, 98166 Messina, Italy.

Angelica Mangano (A)

Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, 98166 Messina, Italy.

Giorgia Pia Lombardo (GP)

Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, 98166 Messina, Italy.

Angelo Giliberti (A)

Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, 98166 Messina, Italy.

Emmanuele Messina (E)

Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, 98166 Messina, Italy.

Alessio Alesci (A)

Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, 98166 Messina, Italy. Electronic address: aalesci@unime.it.

Eugenia Rita Lauriano (ER)

Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, 98166 Messina, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Expression and function of toll-like receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-2 › Expression and function of toll-like receptor...
questionsmedicales.fr › Facteurs biologiques › Molécules contenant des motifs associés aux pathogènes › Expression and function of toll-like receptor...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Expression and function of toll-like receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Expression and function of toll-like receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Expression and function of toll-like receptor...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Expression and function of toll-like receptor...