BDNF Val66Met polymorphism is associated with consolidation of episodic memory during sleep.
Brain-derived neurotrophic factor (BDNF)
Long-term memory
Neural plasticity
Off-line learning
Procedural memory
Val66Met
Verbal memory
Journal
Biological psychology
ISSN: 1873-6246
Titre abrégé: Biol Psychol
Pays: Netherlands
ID NLM: 0375566
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
10
10
2022
revised:
12
04
2023
accepted:
16
04
2023
medline:
15
5
2023
pubmed:
20
4
2023
entrez:
19
04
2023
Statut:
ppublish
Résumé
The brain-derived neurotrophic factor (BDNF) is an essential regulator of synaptic plasticity, a candidate neurobiological mechanism underlying learning and memory. A functional polymorphism in the BDNF gene, Val66Met (rs6265), has been linked to memory and cognition in healthy individuals and clinical populations. Sleep contributes to memory consolidation, yet information about the possible role of BDNF in this process is scarce. To address this question, we investigated the relationship between the BDNF Val66Met genotype and consolidation of episodic declarative and procedural (motor) non-declarative memories in healthy adults. The carriers of Met66 allele, as compared with Val66 homozygotes, showed stronger forgetting overnight (24 h after encoding), but not over shorter time (immediately or 20 min after word list presentation). There was no effect of Val66Met genotype on motor learning. These data suggest that BDNF plays a role in neuroplasticity underlying episodic memory consolidation during sleep.
Identifiants
pubmed: 37075935
pii: S0301-0511(23)00085-6
doi: 10.1016/j.biopsycho.2023.108568
pii:
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
BDNF protein, human
7171WSG8A2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108568Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.