Cytokine-targeted therapies for asthma and COPD.
Journal
European respiratory review : an official journal of the European Respiratory Society
ISSN: 1600-0617
Titre abrégé: Eur Respir Rev
Pays: England
ID NLM: 9111391
Informations de publication
Date de publication:
30 Jun 2023
30 Jun 2023
Historique:
received:
12
10
2022
accepted:
23
01
2023
medline:
21
4
2023
pubmed:
20
4
2023
entrez:
19
04
2023
Statut:
epublish
Résumé
Asthma affects over 300 million people worldwide and its prevalence is increasing. COPD is the third leading cause of death globally. Asthma and COPD are complex inflammatory diseases of the airways in which impaired host defences lead to increased susceptibility to pathogens, pollutants and allergens. There is a constant interplay between host and the environment. Environmental exposures can alter the lung microbiome and influence the development of sensitisation by disrupting normal immunoregulation. The underlying airway inflammation in severe asthma is heterogeneous, with upregulation of type 2 cytokines in most cases but increased neutrophilic inflammation and activated T-helper 17 mediated immunity in others. COPD may also comprise several different phentoypes that are driven by different molecular mechanisms or endotypes. This disease heterogeneity is affected by comorbidities, treatments and environmental exposures. Recent intervention trials have shed light on the pathways beyond type 2 inflammation that can lead to beneficial outcomes
Identifiants
pubmed: 37076177
pii: 32/168/220193
doi: 10.1183/16000617.0193-2022
pmc: PMC10113955
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright ©The authors 2023.
Déclaration de conflit d'intérêts
Conflict of interest: F. Schleich has received grants or contracts from GSK, AstraZeneca and Chiesi; payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing or educational events from GSK, AstraZeneca, Chiesi and TEVA; and has participated on a Data Safety Monitoring Board or Advisory Board for GSK and AstraZeneca. Conflict of interest: N. Bougard has nothing to disclose. Conflict of interest: C. Moermans has nothing to disclose. Conflict of interest: M. Sabbe has nothing to disclose. Conflict of interest: R. Louis has received grants or contracts from GSK, AstraZeneca and Chiesi; payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing or educational events from GSK, AstraZeneca, Chiesi and TEVA; and has participated on a Data Safety Monitoring Board or Advisory Board for GSK and AstraZeneca.
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