Dangerous liaisons: how helminths manipulate the intestinal epithelium.

Animals Intestinal Mucosa Helminths Intestines / parasitology Helminthiasis Intestinal Diseases, Parasitic
epithelial regeneration helminths host defense intestinal epithelium intestinal organoids

Journal

Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034

Informations de publication

Date de publication:
06 2023
Historique:
received: 11 01 2023
revised: 10 03 2023
accepted: 16 03 2023
medline: 15 5 2023
pubmed: 20 4 2023
entrez: 19 04 2023
Statut: ppublish

Résumé

Intestinal helminths remain highly pervasive throughout the animal kingdom by modulating multiple aspects of the host immune response. The intestinal epithelium functions as a physical barrier as well as a sentinel innate immune tissue with the ability to sense and respond to infectious agents. Although helminths form intimate interactions with the epithelium, comprehensive knowledge about host-helminth interactions at this dynamic interface is lacking. In addition, little is known about the ability of helminths to directly shape the fate of this barrier tissue. Here, we review the diverse pathways by which helminths regulate the epithelium and highlight the emerging field of direct helminth regulation of intestinal stem cell (ISC) fate and function.

Identifiants

DOI: 10.1016/j.pt.2023.03.012 PMID: 37076358
pubmed: 37076358
pii: S1471-4922(23)00073-9
doi: 10.1016/j.pt.2023.03.012
pii:
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

414-422

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Danielle Karo-Atar (D)

Department of Microbiology and Immunology, Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada; McGill Interdisciplinary Initiative in Infection and Immunity, Montreal, Quebec, Canada; McGill Regenerative Medicine Network, Montreal, Quebec, Canada. Electronic address: danielle.atarkaro@mail.mcgill.ca.

Alex Gregorieff (A)

McGill Regenerative Medicine Network, Montreal, Quebec, Canada; Department of Pathology, McGill University and Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.

Irah L King (IL)

Department of Microbiology and Immunology, Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada; McGill Interdisciplinary Initiative in Infection and Immunity, Montreal, Quebec, Canada; McGill Regenerative Medicine Network, Montreal, Quebec, Canada; McGill Centre for Microbiome Research, Montreal, Quebec, Canada. Electronic address: irah.king@mcgill.ca.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dangerous liaisons: how helminths manipulate...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Dangerous liaisons: how helminths manipulate...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Dangerous liaisons: how helminths manipulate...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Dangerous liaisons: how helminths manipulate...
questionsmedicales.fr › Infection › Maladies parasitaires › Helminthiase › Dangerous liaisons: how helminths manipulate...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Parasitoses intestinales › Dangerous liaisons: how helminths manipulate...