Exercise-induced circulating exosomes potentially prevent pelvic organ prolapse in clinical practice via inhibition of smooth muscle apoptosis.
Apoptosis
Biomarker
Diagnostic
Exercise
Exosome
Pelvic organ prolapse
miRNA
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
22
07
2022
revised:
14
11
2022
accepted:
15
12
2022
medline:
20
4
2023
pubmed:
20
4
2023
entrez:
20
04
2023
Statut:
epublish
Résumé
This study aimed to explore the potential mechanisms of exercise to prevent pelvic organ prolapse (POP) and search for diagnostic indictors for POP. We used two clinical POP datasets with patients' information (GSE12852 and GSE53868), a dataset consisting of altered microRNA expression in circulating blood after exercise (GSE69717) for bioinformatic analysis and clinical diagnostic analysis, while a series of cellular experiments were conducted for preliminary mechanical validation. Our results show that Our study proved that
Sections du résumé
Background
UNASSIGNED
This study aimed to explore the potential mechanisms of exercise to prevent pelvic organ prolapse (POP) and search for diagnostic indictors for POP.
Methods
UNASSIGNED
We used two clinical POP datasets with patients' information (GSE12852 and GSE53868), a dataset consisting of altered microRNA expression in circulating blood after exercise (GSE69717) for bioinformatic analysis and clinical diagnostic analysis, while a series of cellular experiments were conducted for preliminary mechanical validation.
Results
UNASSIGNED
Our results show that
Conclusions
UNASSIGNED
Our study proved that
Identifiants
pubmed: 37077375
doi: 10.1016/j.heliyon.2022.e12583
pii: S2405-8440(22)03871-3
pmc: PMC10106923
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12583Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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