Interplay between RNA viruses and cGAS/STING axis in innate immunity.
RNA virus
antiviral strategies
cGAS/STING
host-pathogen interactions
innate immunity
viral evasion
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2023
2023
Historique:
received:
27
02
2023
accepted:
21
03
2023
medline:
21
4
2023
pubmed:
20
4
2023
entrez:
20
04
2023
Statut:
epublish
Résumé
While the function of cGAS/STING signalling axis in the innate immune response to DNA viruses is well deciphered, increasing evidence demonstrates its significant contribution in the control of RNA virus infections. After the first evidence of cGAS/STING antagonism by flaviviruses, STING activation has been detected following infection by various enveloped RNA viruses. It has been discovered that numerous viral families have implemented advanced strategies to antagonize STING pathway through their evolutionary path. This review summarizes the characterized cGAS/STING escape strategies to date, together with the proposed mechanisms of STING signalling activation perpetrated by RNA viruses and discusses possible therapeutic approaches. Further studies regarding the interaction between RNA viruses and cGAS/STING-mediated immunity could lead to major discoveries important for the understanding of immunopathogenesis and for the treatment of RNA viral infections.
Identifiants
pubmed: 37077526
doi: 10.3389/fcimb.2023.1172739
pmc: PMC10106766
doi:
Substances chimiques
Nucleotidyltransferases
EC 2.7.7.-
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1172739Informations de copyright
Copyright © 2023 Amurri, Horvat and Iampietro.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Rev Immunol. 2020 Sep;20(9):537-551
pubmed: 32203325
EMBO Rep. 2016 Dec;17(12):1766-1775
pubmed: 27797853
Elife. 2019 Dec 06;8:
pubmed: 31808743
J Hepatol. 2013 Jul;59(1):52-8
pubmed: 23542348
J Virol. 2020 Apr 16;94(9):
pubmed: 32075929
Front Immunol. 2020 Dec 01;11:607069
pubmed: 33335532
Elife. 2012 Dec 18;1:e00047
pubmed: 23251783
Cell Rep. 2020 Aug 18;32(7):108053
pubmed: 32814054
Immunity. 2018 Apr 17;48(4):675-687.e7
pubmed: 29653696
Microbiol Immunol. 2019 Feb;63(2):51-64
pubmed: 30677166
PLoS Pathog. 2012;8(6):e1002780
pubmed: 22761576
J Virol. 2020 Feb 28;94(6):
pubmed: 31896590
Exp Mol Med. 2020 Nov;52(11):1777-1786
pubmed: 33230251
Cytokine Growth Factor Rev. 2014 Dec;25(6):669-79
pubmed: 25212897
Cell. 2019 Jul 11;178(2):290-301.e10
pubmed: 31230712
Cell Res. 2022 May;32(5):495-497
pubmed: 35210607
EXCLI J. 2019 Jun 27;18:467-476
pubmed: 31423125
Front Immunol. 2018 Dec 04;9:2860
pubmed: 30564245
Immunity. 2008 Oct 17;29(4):538-50
pubmed: 18818105
Biochimie. 2003 Aug;85(8):789-93
pubmed: 14585546
Nat Immunol. 2010 Nov;11(11):997-1004
pubmed: 20890285
Nat Commun. 2016 Jun 21;7:11932
pubmed: 27324217
Cell Host Microbe. 2019 Sep 11;26(3):369-384.e8
pubmed: 31513772
Curr Opin Virol. 2022 Jun;54:101228
pubmed: 35533525
Nature. 2013 Jun 20;498(7454):332-7
pubmed: 23722159
Elife. 2018 Mar 20;7:
pubmed: 29557779
Biol Direct. 2021 Oct 21;16(1):20
pubmed: 34674770
iScience. 2021 May 07;24(6):102519
pubmed: 34142033
Sci Immunol. 2021 May 18;6(59):
pubmed: 34010142
Protein Cell. 2016 Nov;7(11):777-791
pubmed: 27696330
Nat Immunol. 2012 Jun 17;13(8):737-43
pubmed: 22706339
Commun Biol. 2022 Jan 12;5(1):45
pubmed: 35022513
Trends Cell Biol. 2022 Nov 24;:
pubmed: 36437149
Viruses. 2023 Feb 28;15(3):
pubmed: 36992355
Nucleic Acids Res. 2017 Jan 9;45(1):198-205
pubmed: 27694309
Cell Mol Life Sci. 2021 Dec;78(23):7427-7434
pubmed: 34714359
Nat Commun. 2016 Feb 19;7:10680
pubmed: 26893169
J Gen Virol. 2013 Jul;94(Pt 7):1554-1567
pubmed: 23596270
PLoS One. 2012;7(6):e38202
pubmed: 22675522
Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15923-15934
pubmed: 32571920
Cell Host Microbe. 2015 Aug 12;18(2):157-68
pubmed: 26235147
PLoS Pathog. 2012;8(10):e1002934
pubmed: 23055924
Nat Microbiol. 2021 Jul;6(7):932-945
pubmed: 33986530
Front Immunol. 2018 Mar 05;9:320
pubmed: 29556226
Nat Rev Microbiol. 2021 Mar;19(3):155-170
pubmed: 33116300
J Virol. 2016 Sep 29;90(20):9406-19
pubmed: 27512060
Front Immunol. 2014 Sep 25;5:461
pubmed: 25309543
Antiviral Res. 2021 Mar;187:105015
pubmed: 33444702
Science. 2015 Mar 13;347(6227):aaa2630
pubmed: 25636800
Cell Host Microbe. 2016 Feb 10;19(2):150-8
pubmed: 26867174
Gut Microbes. 2021 Jan-Dec;13(1):1959839
pubmed: 34347572
PLoS Pathog. 2021 Oct 14;17(10):e1009841
pubmed: 34648591
Sci Rep. 2012;2:347
pubmed: 22470840
PLoS Pathog. 2021 Nov 17;17(11):e1010070
pubmed: 34788350
Viruses. 2021 Sep 14;13(9):
pubmed: 34578409
Nature. 2007 Jul 26;448(7152):501-5
pubmed: 17618271
Nat Rev Mol Cell Biol. 2020 Sep;21(9):501-521
pubmed: 32424334
Science. 2020 Feb 21;367(6480):
pubmed: 32079747
J Biol Chem. 2007 Jul 13;282(28):20059-63
pubmed: 17502367
Vaccines (Basel). 2020 Jul 09;8(3):
pubmed: 32660114
Nature. 2017 Aug 24;548(7668):461-465
pubmed: 28738408
Mol Syst Biol. 2015 Feb 09;11(1):787
pubmed: 25665578
J Biol Chem. 2007 Aug 3;282(31):22816-22
pubmed: 17526488
Mol Cell Biol. 2011 Sep;31(18):3802-19
pubmed: 21791617
Sci Signal. 2021 Mar 09;14(673):
pubmed: 33688080
Trends Immunol. 2017 Mar;38(3):194-205
pubmed: 28073693
Immunity. 2020 Feb 18;52(2):357-373.e9
pubmed: 32049051
Signal Transduct Target Ther. 2022 Dec 23;7(1):394
pubmed: 36550103
Nat Immunol. 2011 Sep 04;12(10):959-65
pubmed: 21892174
Signal Transduct Target Ther. 2021 Mar 15;6(1):123
pubmed: 33723219
Nature. 2020 Nov;587(7835):678-682
pubmed: 32911480
Cell Host Microbe. 2018 Mar 14;23(3):297-301.e4
pubmed: 29478775
Cell Host Microbe. 2021 May 12;29(5):757-764.e3
pubmed: 33730549
Immunity. 2020 May 19;52(5):767-781.e6
pubmed: 32277911
Cell Rep. 2020 Dec 8;33(10):108490
pubmed: 33296647
Fac Rev. 2021 Feb 22;10:17
pubmed: 33718934
PLoS Pathog. 2020 Apr 16;16(4):e1008389
pubmed: 32298390
Sci Immunol. 2021 May 18;6(59):
pubmed: 34010139
EBioMedicine. 2016 Jul;9:87-96
pubmed: 27333035
Nat Commun. 2019 Oct 11;10(1):4624
pubmed: 31604929
Int J Mol Sci. 2022 Jul 01;23(13):
pubmed: 35806369
J Leukoc Biol. 2011 Mar;89(3):351-7
pubmed: 21084628
J Biol Chem. 2012 Aug 17;287(34):28646-55
pubmed: 22745133
Signal Transduct Target Ther. 2021 Apr 30;6(1):170
pubmed: 33927185
Nat Rev Genet. 2019 Nov;20(11):657-674
pubmed: 31358977
Mol Cell. 2019 Jul 25;75(2):372-381.e5
pubmed: 31126740
Nat Commun. 2018 Nov 19;9(1):4841
pubmed: 30451863
J Virol. 2021 May 24;95(12):
pubmed: 33789998
Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15181-6
pubmed: 20696886
Biomed Res Int. 2017;2017:7089091
pubmed: 29201911
Clin Vaccine Immunol. 2014 Jan;21(1):29-38
pubmed: 24173023
BMC Mol Biol. 2007 Apr 25;8:29
pubmed: 17459151
Mol Cell. 2020 May 21;78(4):624-640.e7
pubmed: 32380061
Viruses. 2020 Sep 03;12(9):
pubmed: 32899347
BMJ. 2020 Oct 23;371:m3862
pubmed: 33097561
Sci Signal. 2022 Apr 12;15(729):eabg8744
pubmed: 35412852
Nature. 2009 Oct 8;461(7265):788-92
pubmed: 19776740
Front Med. 2021 Jun;15(3):333-346
pubmed: 33263837
EMBO J. 1992 Sep;11(9):3431-40
pubmed: 1324173
Signal Transduct Target Ther. 2021 Jul 9;6(1):260
pubmed: 34244470
Immunity. 2017 Mar 21;46(3):393-404
pubmed: 28314590
J Gen Virol. 2009 Jan;90(Pt 1):74-8
pubmed: 19088275
Immunohorizons. 2018 Dec 11;2(11):363-376
pubmed: 31026807
PLoS Pathog. 2019 Aug 15;15(8):e1007899
pubmed: 31415679
Nature. 2019 Sep;573(7774):434-438
pubmed: 31511694
Immunity. 2016 Mar 15;44(3):597-608
pubmed: 26944200
Nature. 2013 Nov 28;503(7477):530-4
pubmed: 24077100
Cell Host Microbe. 2016 Sep 14;20(3):342-356
pubmed: 27545046
Mediators Inflamm. 2018 Nov 25;2018:1202797
pubmed: 30595664
Nat Nanotechnol. 2019 Mar;14(3):269-278
pubmed: 30664751
J Infect Dis. 2020 May 11;221(Suppl 4):S401-S406
pubmed: 31853535
J Med Virol. 2021 Sep;93(9):5376-5389
pubmed: 33913550
Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2058-E2067
pubmed: 29440426
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6310-E6318
pubmed: 29915078
J Infect Dis. 2021 Jun 15;223(12):2186-2196
pubmed: 33161431
Sci Signal. 2012 Mar 06;5(214):ra20
pubmed: 22394562
PLoS Pathog. 2020 Oct 15;16(10):e1008999
pubmed: 33057424
Science. 2015 Oct 30;350(6260):568-71
pubmed: 26405230
Nat Immunol. 2010 Nov;11(11):984-6
pubmed: 20959802
J Virol. 2010 May;84(9):4845-50
pubmed: 20164230
Cell Rep. 2020 Apr 7;31(1):107492
pubmed: 32268090
F1000Res. 2016 Jan 26;5:
pubmed: 26918172
J Virol. 2005 Feb;79(3):1343-50
pubmed: 15650160
Mol Cell. 2018 Sep 6;71(5):745-760.e5
pubmed: 30193098
Hepatology. 2013 Jan;57(1):46-58
pubmed: 22911572
Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):
pubmed: 33785602
EMBO J. 2018 Sep 14;37(18):
pubmed: 30065070
Nature. 2008 Oct 2;455(7213):674-8
pubmed: 18724357
J Immunol. 2019 Dec 15;203(12):3374-3385
pubmed: 31704883
Eur J Med Chem. 2022 Aug 5;238:114480
pubmed: 35635952
Cell Rep. 2023 Mar 28;42(3):112179
pubmed: 36943868
Science. 2015 Sep 11;349(6253):1232-6
pubmed: 26229115
Nature. 2022 Mar;603(7899):145-151
pubmed: 35045565
Nat Microbiol. 2017 Mar 27;2:17037
pubmed: 28346446
Cell Biol Toxicol. 2016 Oct;32(5):437-49
pubmed: 27344565
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2969-74
pubmed: 23388631
Immunity. 2010 Nov 24;33(5):765-76
pubmed: 21074459
Science. 2015 Sep 11;349(6253):1228-32
pubmed: 26229117
PLoS One. 2012;7(2):e30802
pubmed: 22312431
Cell. 2009 Aug 7;138(3):576-91
pubmed: 19631370